Motif ID: Sox1

Z-value: 0.281


Transcription factors associated with Sox1:

Gene SymbolEntrez IDGene Name
Sox1 ENSMUSG00000096014.1 Sox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox1mm10_v2_chr8_+_12395287_123952950.231.7e-01Click!


Activity profile for motif Sox1.

activity profile for motif Sox1


Sorted Z-values histogram for motif Sox1

Sorted Z-values for motif Sox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_75048837 0.882 ENSMUST00000179762.1
ENSMUST00000065408.9
 Ly6c1

lymphocyte antigen 6 complex, locus C1

chr7_-_57509995 0.759 ENSMUST00000068456.6
 Gabra5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
chr17_-_47692466 0.664 ENSMUST00000113300.1
 Prickle4
prickle homolog 4 (Drosophila)
chr15_-_74997634 0.492 ENSMUST00000023248.6
 Ly6a
lymphocyte antigen 6 complex, locus A
chr9_-_114390633 0.433 ENSMUST00000084881.4
 Crtap
cartilage associated protein
chr11_+_104282371 0.334 ENSMUST00000106988.1
ENSMUST00000106989.1
 Mapt

microtubule-associated protein tau

chrX_+_74297097 0.325 ENSMUST00000019231.5
ENSMUST00000147900.1
ENSMUST00000147275.1
ENSMUST00000114171.3
 Atp6ap1



ATPase, H+ transporting, lysosomal accessory protein 1



chr6_+_117841174 0.302 ENSMUST00000112859.1
ENSMUST00000137224.1
ENSMUST00000164472.1
ENSMUST00000112861.1
ENSMUST00000035638.8
 Zfp637




zinc finger protein 637




chr16_-_37654408 0.269 ENSMUST00000023514.3
 Ndufb4
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4
chr4_-_120747248 0.259 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr8_+_13159135 0.247 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr17_+_34263209 0.244 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr7_+_80343091 0.234 ENSMUST00000032747.5
 Hddc3
HD domain containing 3
chr3_-_34005490 0.233 ENSMUST00000060997.2
 Gm9791
predicted pseudogene 9791
chr6_+_114648811 0.219 ENSMUST00000182510.1
 Atg7
autophagy related 7
chr17_+_47737030 0.214 ENSMUST00000086932.3
 Tfeb
transcription factor EB
chr11_-_68853119 0.194 ENSMUST00000018880.7
 Ndel1
nuclear distribution gene E-like homolog 1 (A. nidulans)
chr18_+_37496997 0.165 ENSMUST00000059571.5
 Pcdhb19
protocadherin beta 19
chr11_-_68853019 0.164 ENSMUST00000108672.1
 Ndel1
nuclear distribution gene E-like homolog 1 (A. nidulans)
chr4_+_136357423 0.158 ENSMUST00000182167.1
 Gm17388
predicted gene, 17388
chr9_-_108305941 0.127 ENSMUST00000044725.7
 Tcta
T cell leukemia translocation altered gene
chr1_-_195131536 0.122 ENSMUST00000075451.6
 Cr1l
complement component (3b/4b) receptor 1-like
chr17_-_34287770 0.120 ENSMUST00000174751.1
ENSMUST00000040655.6
 H2-Aa

histocompatibility 2, class II antigen A, alpha

chr6_+_121183667 0.104 ENSMUST00000118234.1
ENSMUST00000088561.3
ENSMUST00000137432.1
ENSMUST00000120066.1
 Pex26



peroxisomal biogenesis factor 26



chr17_+_34969912 0.099 ENSMUST00000173680.1
 Gm20481
predicted gene 20481
chr7_+_119690026 0.068 ENSMUST00000047045.8
 Acsm4
acyl-CoA synthetase medium-chain family member 4
chr5_+_21737141 0.058 ENSMUST00000030882.5
 Pmpcb
peptidase (mitochondrial processing) beta
chr10_+_84756055 0.041 ENSMUST00000060397.6
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr15_-_76918010 0.033 ENSMUST00000048854.7
 Zfp647
zinc finger protein 647
chr5_+_21186267 0.019 ENSMUST00000036031.8
 Gsap
gamma-secretase activating protein
chr14_-_30923547 0.019 ENSMUST00000170415.1
 Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr5_-_140649018 0.011 ENSMUST00000042661.3
 Ttyh3
tweety homolog 3 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 0.2 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626) positive regulation of natural killer cell degranulation(GO:0043323)
0.1 0.2 GO:0016237 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521) negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis(GO:0090157)
0.1 0.2 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.1 0.3 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0 0.2 GO:0002339 B cell selection(GO:0002339)
0.0 0.4 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.3 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.0 0.4 GO:0030397 membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0 0.8 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.1 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.1 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.1 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.1 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0044194 cytolytic granule(GO:0044194)
0.1 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.4 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.3 GO:0045298 tubulin complex(GO:0045298)
0.0 1.4 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070012 oligopeptidase activity(GO:0070012)
0.1 0.2 GO:0019779 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.0 0.3 GO:0099609 microtubule lateral binding(GO:0099609)
0.0 0.8 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.2 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.1 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins