Motif ID: Sox11

Z-value: 0.472


Transcription factors associated with Sox11:

Gene SymbolEntrez IDGene Name
Sox11 ENSMUSG00000063632.5 Sox11

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox11mm10_v2_chr12_-_27342696_273427260.741.5e-07Click!


Activity profile for motif Sox11.

activity profile for motif Sox11


Sorted Z-values histogram for motif Sox11

Sorted Z-values for motif Sox11



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox11

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_47418407 2.398 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr9_+_65890237 2.154 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr6_-_23248264 1.861 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr16_-_50330987 1.454 ENSMUST00000114488.1
 Bbx
bobby sox homolog (Drosophila)
chr9_-_16378231 1.444 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr4_-_97584612 1.393 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584605 1.389 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_+_154548888 1.350 ENSMUST00000045116.4
ENSMUST00000109709.3
 1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr1_+_82233112 1.189 ENSMUST00000023262.5
 Gm9747
predicted gene 9747
chr2_-_79456750 1.120 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr5_+_64812336 1.010 ENSMUST00000166409.1
 Klf3
Kruppel-like factor 3 (basic)
chr16_-_44558864 0.985 ENSMUST00000023370.4
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr9_+_52047150 0.902 ENSMUST00000163153.1
 Rdx
radixin
chr11_-_50292302 0.848 ENSMUST00000059458.4
 Maml1
mastermind like 1 (Drosophila)
chr16_-_44558879 0.805 ENSMUST00000114634.1
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr2_+_15055274 0.748 ENSMUST00000069870.3
 Arl5b
ADP-ribosylation factor-like 5B
chr5_-_131616599 0.735 ENSMUST00000161804.1
 Auts2
autism susceptibility candidate 2
chr10_+_17796256 0.735 ENSMUST00000037964.6
 Txlnb
taxilin beta
chr7_+_83631959 0.718 ENSMUST00000075418.7
ENSMUST00000117410.1
 Stard5

StAR-related lipid transfer (START) domain containing 5

chr13_-_99516537 0.706 ENSMUST00000064762.4
 Map1b
microtubule-associated protein 1B
chr11_-_64436653 0.684 ENSMUST00000177999.1
 F930015N05Rik
RIKEN cDNA F930015N05 gene
chr7_-_73541738 0.559 ENSMUST00000169922.2
 Chd2
chromodomain helicase DNA binding protein 2
chr7_+_70388305 0.536 ENSMUST00000080024.5
 B130024G19Rik
RIKEN cDNA B130024G19 gene
chr3_+_134236483 0.514 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr16_+_8830093 0.509 ENSMUST00000023150.5
 1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr15_+_76797628 0.507 ENSMUST00000165535.2
 Gm17271
predicted gene, 17271
chr5_-_148552783 0.489 ENSMUST00000079324.7
ENSMUST00000164904.1
 Ubl3

ubiquitin-like 3

chr10_-_76110956 0.486 ENSMUST00000120757.1
 Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr14_-_52213379 0.450 ENSMUST00000140603.1
 Chd8
chromodomain helicase DNA binding protein 8
chr17_-_29007925 0.440 ENSMUST00000009138.5
ENSMUST00000119274.1
 Stk38

serine/threonine kinase 38

chr6_-_42693030 0.433 ENSMUST00000045140.4
 Fam115a
family with sequence similarity 115, member A
chr3_+_60877002 0.431 ENSMUST00000099086.2
 Gm8325
predicted pseudogene 8325
chr6_-_42693087 0.431 ENSMUST00000121083.1
 Fam115a
family with sequence similarity 115, member A
chr7_-_55962466 0.381 ENSMUST00000032635.7
ENSMUST00000152649.1
 Nipa2

non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human)

chr6_-_12109583 0.353 ENSMUST00000080891.5
 Gm6578
predicted gene 6578
chr5_+_14514918 0.341 ENSMUST00000030691.10
ENSMUST00000182407.1
 Pclo

piccolo (presynaptic cytomatrix protein)

chr10_+_119992916 0.336 ENSMUST00000105261.2
 Grip1
glutamate receptor interacting protein 1
chr3_+_67430096 0.333 ENSMUST00000077271.6
ENSMUST00000161009.1
 Gfm1

G elongation factor, mitochondrial 1

chr7_-_105737376 0.304 ENSMUST00000098148.4
 Rrp8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr9_+_107888129 0.293 ENSMUST00000035202.2
 Mon1a
MON1 homolog A (yeast)
chr1_+_44119952 0.292 ENSMUST00000114709.2
 Bivm
basic, immunoglobulin-like variable motif containing
chr5_+_121795034 0.287 ENSMUST00000162327.1
 Atxn2
ataxin 2
chr16_-_38341812 0.282 ENSMUST00000114740.2
ENSMUST00000023501.8
 Maats1

MYCBP-associated, testis expressed 1

chr1_-_45503282 0.274 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr3_+_28805436 0.270 ENSMUST00000043867.5
 Rpl22l1
ribosomal protein L22 like 1
chr2_-_36136602 0.265 ENSMUST00000122456.1
 Rbm18
RNA binding motif protein 18
chrX_-_37104523 0.253 ENSMUST00000130324.1
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr9_+_101074727 0.247 ENSMUST00000085177.3
 Msl2
male-specific lethal 2 homolog (Drosophila)
chr10_+_115569986 0.247 ENSMUST00000173620.1
 A930009A15Rik
RIKEN cDNA A930009A15 gene
chr13_-_41487306 0.245 ENSMUST00000021794.6
 Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
chr2_-_156111954 0.228 ENSMUST00000142960.2
ENSMUST00000136296.2
ENSMUST00000059647.5
ENSMUST00000109604.2
ENSMUST00000138068.1
ENSMUST00000128499.1
 Cpne1

Rbm12



copine I

RNA binding motif protein 12



chr11_+_69364010 0.223 ENSMUST00000166700.1
 Gm17305
predicted gene, 17305
chr2_-_36136773 0.217 ENSMUST00000028251.3
 Rbm18
RNA binding motif protein 18
chr12_-_54862783 0.215 ENSMUST00000078124.7
 Cfl2
cofilin 2, muscle
chr4_-_43030440 0.196 ENSMUST00000135660.1
 Stoml2
stomatin (Epb7.2)-like 2
chr2_-_86347764 0.186 ENSMUST00000099894.2
 Olfr1055
olfactory receptor 1055
chr11_+_4873951 0.162 ENSMUST00000038570.2
 Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr11_+_98937669 0.158 ENSMUST00000107475.2
ENSMUST00000068133.3
 Rara

retinoic acid receptor, alpha

chr10_-_14718191 0.123 ENSMUST00000020016.4
 Gje1
gap junction protein, epsilon 1
chr8_-_83442648 0.093 ENSMUST00000167525.1
 Scoc
short coiled-coil protein
chr2_-_127247620 0.067 ENSMUST00000174030.1
ENSMUST00000174863.1
 Ciao1

cytosolic iron-sulfur protein assembly 1

chr15_-_81104999 0.058 ENSMUST00000109579.2
 Mkl1
MKL (megakaryoblastic leukemia)/myocardin-like 1
chr16_+_65520503 0.057 ENSMUST00000176330.1
ENSMUST00000004964.8
ENSMUST00000176038.1
 Pou1f1


POU domain, class 1, transcription factor 1


chr13_+_40859768 0.057 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr5_+_8046077 0.056 ENSMUST00000088786.4
 Sri
sorcin
chr10_+_24869982 0.042 ENSMUST00000092646.6
 Med23
mediator complex subunit 23
chr19_-_46969474 0.029 ENSMUST00000086961.7
 Nt5c2
5'-nucleotidase, cytosolic II
chr13_+_24327415 0.015 ENSMUST00000167746.1
 Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr17_+_43016536 0.009 ENSMUST00000024708.4
 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chrX_+_166344692 0.006 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 0.8 GO:0003162 atrioventricular node development(GO:0003162)
0.3 1.1 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.2 0.7 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.1 0.9 GO:1902965 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.1 0.3 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.1 0.5 GO:1904659 glucose transmembrane transport(GO:1904659)
0.1 0.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 1.8 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.1 0.2 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 0.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.7 GO:0070508 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.0 1.4 GO:0010842 retina layer formation(GO:0010842)
0.0 0.7 GO:0061339 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0 0.4 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.3 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 0.6 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.4 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.0 0.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.0 GO:2000409 positive regulation of T cell extravasation(GO:2000409)
0.0 0.2 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 2.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.3 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 0.3 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.9 GO:0051286 cell tip(GO:0051286)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.7 GO:0043196 varicosity(GO:0043196)
0.0 1.8 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.1 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0032052 bile acid binding(GO:0032052)
0.1 0.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.5 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.8 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 1.1 GO:0070888 E-box binding(GO:0070888)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.2 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 2.4 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 1.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 ST_GA13_PATHWAY G alpha 13 Pathway
0.0 0.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.1 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.9 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1