Motif ID: Sox14

Z-value: 0.877


Transcription factors associated with Sox14:

Gene SymbolEntrez IDGene Name
Sox14 ENSMUSG00000053747.8 Sox14

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox14mm10_v2_chr9_-_99876147_998761930.048.1e-01Click!


Activity profile for motif Sox14.

activity profile for motif Sox14


Sorted Z-values histogram for motif Sox14

Sorted Z-values for motif Sox14



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox14

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 7.678 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr4_+_62965560 4.004 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chr12_+_109546333 3.343 ENSMUST00000166636.2
 Meg3
maternally expressed 3
chr4_+_13751297 3.269 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr10_-_6980376 3.087 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr12_+_109546409 3.041 ENSMUST00000143847.1
 Meg3
maternally expressed 3
chr4_+_102254739 2.965 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr13_-_58113592 2.746 ENSMUST00000160860.1
 Klhl3
kelch-like 3
chr11_+_67586675 2.669 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr9_+_65265173 2.473 ENSMUST00000048762.1
 Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr12_+_109545390 2.444 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr11_+_67586520 2.444 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chrX_-_167209149 2.271 ENSMUST00000112176.1
 Tmsb4x
thymosin, beta 4, X chromosome
chr14_-_104467984 2.238 ENSMUST00000053016.8
 Pou4f1
POU domain, class 4, transcription factor 1
chr14_-_98169542 2.224 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr2_-_102186322 2.205 ENSMUST00000111222.1
ENSMUST00000058790.5
 Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr11_-_12037391 1.971 ENSMUST00000093321.5
 Grb10
growth factor receptor bound protein 10
chr12_-_32061221 1.965 ENSMUST00000003079.5
ENSMUST00000036497.9
 Prkar2b

protein kinase, cAMP dependent regulatory, type II beta

chr13_+_5861489 1.944 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr13_-_14523178 1.830 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.3 GO:0008340 determination of adult lifespan(GO:0008340)
1.3 7.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 6.3 GO:0008360 regulation of cell shape(GO:0008360)
0.1 3.3 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.2 3.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 3.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 2.8 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.5 2.7 GO:0070294 renal sodium ion absorption(GO:0070294)
0.3 2.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.4 2.2 GO:0019230 proprioception(GO:0019230)
0.1 2.2 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 2.2 GO:0070613 regulation of protein processing(GO:0070613)
0.5 2.0 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.2 2.0 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.3 1.9 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 1.8 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 1.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.6 1.7 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.6 1.7 GO:0030070 insulin processing(GO:0030070)
0.2 1.7 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.0 GO:0005884 actin filament(GO:0005884)
0.0 4.4 GO:0016363 nuclear matrix(GO:0016363)
0.1 3.1 GO:0043034 costamere(GO:0043034)
0.0 3.1 GO:0043204 perikaryon(GO:0043204)
0.1 3.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 2.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.2 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 2.1 GO:0014069 postsynaptic density(GO:0014069)
0.5 2.0 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.2 2.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.0 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.9 GO:0001725 stress fiber(GO:0001725) actin filament bundle(GO:0032432) contractile actin filament bundle(GO:0097517)
0.0 1.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.3 1.4 GO:0008623 CHRAC(GO:0008623)
0.0 1.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.3 1.1 GO:0090537 CERF complex(GO:0090537)
0.1 1.1 GO:0071564 npBAF complex(GO:0071564)
0.0 1.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 1.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 5.2 GO:0051015 actin filament binding(GO:0051015)
0.1 4.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 3.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 3.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 3.2 GO:0005080 protein kinase C binding(GO:0005080)
0.3 3.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 3.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 2.8 GO:0003779 actin binding(GO:0003779)
0.1 2.3 GO:0003785 actin monomer binding(GO:0003785)
0.0 2.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 2.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 2.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 2.0 GO:0043208 glycosphingolipid binding(GO:0043208)
0.2 2.0 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 2.0 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.5 1.5 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 1.5 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 1.5 GO:0035064 methylated histone binding(GO:0035064)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 2.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.2 PID_IGF1_PATHWAY IGF1 pathway
0.3 2.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.9 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 1.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.7 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 1.4 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 0.9 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.7 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.5 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 2.0 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 1.9 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.7 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.4 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.4 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.3 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.2 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 0.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.7 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.7 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex