Motif ID: Sox17

Z-value: 0.543


Transcription factors associated with Sox17:

Gene SymbolEntrez IDGene Name
Sox17 ENSMUSG00000025902.7 Sox17

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox17mm10_v2_chr1_-_4496400_4496420-0.464.4e-03Click!


Activity profile for motif Sox17.

activity profile for motif Sox17


Sorted Z-values histogram for motif Sox17

Sorted Z-values for motif Sox17



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox17

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 70 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_127725392 4.528 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr6_-_23248264 4.380 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_-_11970540 2.966 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr2_+_102659213 2.887 ENSMUST00000111213.1
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr8_-_105471481 2.350 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr1_+_135729147 2.182 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr11_-_77894096 1.971 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr14_+_50944499 1.959 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr12_+_24708241 1.640 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr10_-_128176568 1.576 ENSMUST00000092033.2
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr2_-_127133909 1.515 ENSMUST00000110387.3
 Ncaph
non-SMC condensin I complex, subunit H
chr6_-_148944750 1.460 ENSMUST00000111562.1
ENSMUST00000081956.5
 Fam60a

family with sequence similarity 60, member A

chr14_+_31134853 1.450 ENSMUST00000090212.4
 Nt5dc2
5'-nucleotidase domain containing 2
chr4_+_118961578 1.387 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr2_-_180889660 1.381 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr2_+_52857844 1.323 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
 Fmnl2


formin-like 2


chr19_+_55741810 1.110 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr13_-_35027077 1.094 ENSMUST00000170538.1
ENSMUST00000163280.1
 Eci2

enoyl-Coenzyme A delta isomerase 2

chr6_+_121245903 1.059 ENSMUST00000032198.9
 Usp18
ubiquitin specific peptidase 18
chr12_+_51348265 0.987 ENSMUST00000119211.1
 G2e3
G2/M-phase specific E3 ubiquitin ligase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 4.5 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.7 4.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 3.0 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.4 2.9 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 2.8 GO:0001824 blastocyst development(GO:0001824)
0.0 2.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 2.2 GO:0070527 platelet aggregation(GO:0070527)
0.7 2.0 GO:0006553 lysine metabolic process(GO:0006553)
0.7 2.0 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.1 1.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.5 1.5 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0 1.4 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 1.3 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 1.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 1.1 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.0 1.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 0.9 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0 0.9 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.8 GO:0030813 positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197)
0.1 0.7 GO:1902741 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0042734 presynaptic membrane(GO:0042734)
0.3 2.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 2.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 1.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.5 1.5 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 1.5 GO:0016580 Sin3 complex(GO:0016580)
0.1 1.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 0.9 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.3 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.3 GO:0034464 BBSome(GO:0034464)
0.0 0.3 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.1 GO:0071953 fibrinogen complex(GO:0005577) elastic fiber(GO:0071953)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 3.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.5 2.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.7 2.0 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.5 2.0 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.3 1.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 1.5 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.5 1.4 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 1.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 1.1 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 1.1 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.3 0.9 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.2 0.8 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.2 0.7 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 0.3 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.3 GO:0008494 translation activator activity(GO:0008494)
0.0 0.3 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.6 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.4 PID_IL27_PATHWAY IL27-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 2.9 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 2.0 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.6 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.1 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 0.7 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane