Motif ID: Sox17

Z-value: 0.543


Transcription factors associated with Sox17:

Gene SymbolEntrez IDGene Name
Sox17 ENSMUSG00000025902.7 Sox17

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox17mm10_v2_chr1_-_4496400_4496420-0.464.4e-03Click!


Activity profile for motif Sox17.

activity profile for motif Sox17


Sorted Z-values histogram for motif Sox17

Sorted Z-values for motif Sox17



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox17

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_127725392 4.528 ENSMUST00000026466.3
Tac2
tachykinin 2
chr6_-_23248264 4.380 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr11_-_11970540 2.966 ENSMUST00000109653.1
Grb10
growth factor receptor bound protein 10
chr2_+_102659213 2.887 ENSMUST00000111213.1
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr8_-_105471481 2.350 ENSMUST00000014990.6
Tppp3
tubulin polymerization-promoting protein family member 3
chr1_+_135729147 2.182 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr11_-_77894096 1.971 ENSMUST00000017597.4
Pipox
pipecolic acid oxidase
chr14_+_50944499 1.959 ENSMUST00000178092.1
Pnp
purine-nucleoside phosphorylase
chr12_+_24708241 1.640 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr10_-_128176568 1.576 ENSMUST00000092033.2
Rbms2
RNA binding motif, single stranded interacting protein 2
chr2_-_127133909 1.515 ENSMUST00000110387.3
Ncaph
non-SMC condensin I complex, subunit H
chr6_-_148944750 1.460 ENSMUST00000111562.1
ENSMUST00000081956.5
Fam60a

family with sequence similarity 60, member A

chr14_+_31134853 1.450 ENSMUST00000090212.4
Nt5dc2
5'-nucleotidase domain containing 2
chr4_+_118961578 1.387 ENSMUST00000058651.4
Lao1
L-amino acid oxidase 1
chr2_-_180889660 1.381 ENSMUST00000137629.1
Gm14342
predicted gene 14342
chr2_+_52857844 1.323 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
Fmnl2


formin-like 2


chr19_+_55741810 1.110 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr13_-_35027077 1.094 ENSMUST00000170538.1
ENSMUST00000163280.1
Eci2

enoyl-Coenzyme A delta isomerase 2

chr6_+_121245903 1.059 ENSMUST00000032198.9
Usp18
ubiquitin specific peptidase 18
chr12_+_51348265 0.987 ENSMUST00000119211.1
G2e3
G2/M-phase specific E3 ubiquitin ligase
chr12_+_51348370 0.959 ENSMUST00000121521.1
G2e3
G2/M-phase specific E3 ubiquitin ligase
chr15_-_96460838 0.891 ENSMUST00000047835.6
Scaf11
SR-related CTD-associated factor 11
chr12_+_51348019 0.834 ENSMUST00000054308.6
G2e3
G2/M-phase specific E3 ubiquitin ligase
chr4_-_119173849 0.779 ENSMUST00000052715.4
ENSMUST00000179290.1
ENSMUST00000154226.1
Zfp691


zinc finger protein 691


chr10_+_81821127 0.767 ENSMUST00000099439.3
Gm4767
predicted gene 4767
chr11_-_86807624 0.746 ENSMUST00000018569.7
Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr10_+_81661998 0.744 ENSMUST00000105315.2
Gm10778
predicted gene 10778
chr14_+_73142591 0.671 ENSMUST00000170368.1
Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr19_-_44107447 0.665 ENSMUST00000119591.1
ENSMUST00000026217.4
Chuk

conserved helix-loop-helix ubiquitous kinase

chrX_+_123103546 0.636 ENSMUST00000113348.1
3110007F17Rik
RIKEN cDNA 3110007F17 gene
chrX_+_123103489 0.572 ENSMUST00000113343.1
3110007F17Rik
RIKEN cDNA 3110007F17 gene
chr18_+_35599219 0.460 ENSMUST00000115734.1
Paip2
polyadenylate-binding protein-interacting protein 2
chr5_-_107597577 0.449 ENSMUST00000100949.3
ENSMUST00000078021.6
Glmn

glomulin, FKBP associated protein

chr9_+_108392820 0.446 ENSMUST00000035234.4
1700102P08Rik
RIKEN cDNA 1700102P08 gene
chr14_+_73142490 0.446 ENSMUST00000170370.1
ENSMUST00000164822.1
ENSMUST00000165429.1
Rcbtb2


regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2


chr5_-_107597533 0.426 ENSMUST00000124140.1
Glmn
glomulin, FKBP associated protein
chr10_-_59221757 0.403 ENSMUST00000165971.1
Sept10
septin 10
chr12_-_84400851 0.396 ENSMUST00000117286.1
Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
chrX_+_48695004 0.392 ENSMUST00000033433.2
Rbmx2
RNA binding motif protein, X-linked 2
chr1_+_52008210 0.386 ENSMUST00000027277.5
Stat4
signal transducer and activator of transcription 4
chr12_-_84400929 0.379 ENSMUST00000122194.1
Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
chr5_-_130002838 0.365 ENSMUST00000111308.1
ENSMUST00000111307.1
Gusb

glucuronidase, beta

chr7_-_127890918 0.350 ENSMUST00000121394.1
Prss53
protease, serine, 53
chr4_-_135971894 0.331 ENSMUST00000105852.1
Lypla2
lysophospholipase 2
chr8_-_94098811 0.329 ENSMUST00000034206.4
Bbs2
Bardet-Biedl syndrome 2 (human)
chr9_+_66946057 0.325 ENSMUST00000040917.7
ENSMUST00000127896.1
Rps27l

ribosomal protein S27-like

chr17_-_55712571 0.320 ENSMUST00000086876.5
Pot1b
protection of telomeres 1B
chr7_-_79466167 0.302 ENSMUST00000073889.7
Polg
polymerase (DNA directed), gamma
chr8_-_41054771 0.267 ENSMUST00000093534.4
Mtus1
mitochondrial tumor suppressor 1
chr2_-_26409100 0.262 ENSMUST00000114090.1
Inpp5e
inositol polyphosphate-5-phosphatase E
chr3_-_158016419 0.223 ENSMUST00000127778.1
Srsf11
serine/arginine-rich splicing factor 11
chr10_+_93453382 0.220 ENSMUST00000016033.7
Lta4h
leukotriene A4 hydrolase
chr11_-_97775876 0.205 ENSMUST00000107576.1
1700001P01Rik
RIKEN cDNA 1700001P01 gene
chr9_+_3335470 0.199 ENSMUST00000053407.5
Alkbh8
alkB, alkylation repair homolog 8 (E. coli)
chr2_+_121456963 0.158 ENSMUST00000126764.1
Hypk
huntingtin interacting protein K
chr7_+_126976338 0.142 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr9_+_21337828 0.138 ENSMUST00000034697.7
Slc44a2
solute carrier family 44, member 2
chr4_-_131937165 0.111 ENSMUST00000155990.1
Epb4.1
erythrocyte protein band 4.1
chr15_+_85205949 0.111 ENSMUST00000057410.7
ENSMUST00000109432.3
Fbln1

fibulin 1

chr9_+_50494516 0.102 ENSMUST00000114474.1
1600029D21Rik
RIKEN cDNA 1600029D21 gene
chr8_+_4248188 0.095 ENSMUST00000110993.1
Gm14378
predicted gene 14378
chr8_+_71887264 0.085 ENSMUST00000034259.7
Zfp709
zinc finger protein 709
chr2_+_55411790 0.062 ENSMUST00000155997.1
ENSMUST00000128307.1
Gm14033

predicted gene 14033

chr19_+_6306456 0.061 ENSMUST00000025681.7
Cdc42bpg
CDC42 binding protein kinase gamma (DMPK-like)
chr19_+_8920358 0.051 ENSMUST00000096243.5
B3gat3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr10_+_59221945 0.047 ENSMUST00000182161.1
Sowahc
sosondowah ankyrin repeat domain family member C
chr7_-_98112618 0.046 ENSMUST00000153657.1
Myo7a
myosin VIIA
chr18_+_60560730 0.036 ENSMUST00000025506.6
Rbm22
RNA binding motif protein 22
chr15_+_74721193 0.035 ENSMUST00000070923.1
Them6
thioesterase superfamily member 6
chr2_-_142901506 0.031 ENSMUST00000043589.7
Kif16b
kinesin family member 16B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.7 4.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.7 2.0 GO:0006553 lysine metabolic process(GO:0006553)
0.7 2.0 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.5 1.5 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.4 2.9 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3 3.0 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 1.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 1.1 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.1 0.3 GO:0048239 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.1 0.9 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.1 1.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 0.7 GO:1902741 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.1 0.3 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.1 0.3 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.1 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.2 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.0 1.3 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) transforming growth factor-beta secretion(GO:0038044) blood coagulation, fibrin clot formation(GO:0072378)
0.0 0.8 GO:0030813 positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197)
0.0 2.2 GO:0070527 platelet aggregation(GO:0070527)
0.0 2.8 GO:0001824 blastocyst development(GO:0001824)
0.0 2.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.5 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.3 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 1.4 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 0.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.3 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.9 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 1.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.1 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0000799 nuclear condensin complex(GO:0000799)
0.3 1.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 2.4 GO:0097427 microtubule bundle(GO:0097427)
0.1 1.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.5 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.9 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.1 GO:0071953 fibrinogen complex(GO:0005577) elastic fiber(GO:0071953)
0.0 2.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.3 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.3 GO:0034464 BBSome(GO:0034464)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.3 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.5 2.0 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.5 2.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 1.4 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.3 1.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 0.9 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.3 1.5 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.2 0.7 GO:0008384 IkappaB kinase activity(GO:0008384)
0.2 1.1 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.2 0.8 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.1 1.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.3 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 3.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.3 GO:0008494 translation activator activity(GO:0008494)
0.1 1.1 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.3 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.2 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 4.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.4 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 1.6 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.1 PID_AP1_PATHWAY AP-1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 3.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.6 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.1 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 0.7 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 2.9 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane