Motif ID: Sox2

Z-value: 3.567


Transcription factors associated with Sox2:

Gene SymbolEntrez IDGene Name
Sox2 ENSMUSG00000074637.4 Sox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox2mm10_v2_chr3_+_34649987_346500050.529.9e-04Click!


Activity profile for motif Sox2.

activity profile for motif Sox2


Sorted Z-values histogram for motif Sox2

Sorted Z-values for motif Sox2



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_45216671 37.560 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr7_-_115824699 32.719 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr7_-_49636847 31.148 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr1_-_138842429 29.940 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr7_-_116038734 28.666 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr9_+_118478851 24.097 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr1_+_6734827 22.808 ENSMUST00000139838.1
 St18
suppression of tumorigenicity 18
chr9_+_118478344 22.697 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr11_+_119022962 21.787 ENSMUST00000026662.7
 Cbx2
chromobox 2
chr1_+_6487231 19.382 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr17_-_70851189 19.337 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr5_-_98030727 18.744 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr15_+_25622525 18.694 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr17_-_35703971 18.469 ENSMUST00000148065.1
 Ddr1
discoidin domain receptor family, member 1
chr7_+_45215753 18.083 ENSMUST00000033060.6
ENSMUST00000155313.1
ENSMUST00000107801.1
 Tead2


TEA domain family member 2


chr17_-_35704000 18.025 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chr11_-_114795888 17.999 ENSMUST00000000206.3
 Btbd17
BTB (POZ) domain containing 17
chr4_+_62965560 17.512 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chr10_+_26229707 17.209 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr3_-_75956888 16.685 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
 Golim4


golgi integral membrane protein 4



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 424 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.0 87.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
3.3 76.2 GO:0048368 lateral mesoderm development(GO:0048368)
5.3 63.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
3.8 61.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
4.7 56.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
15.6 46.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
3.6 39.2 GO:0060539 diaphragm development(GO:0060539)
1.8 38.8 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
2.6 33.2 GO:0035881 amacrine cell differentiation(GO:0035881)
2.1 31.1 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
6.0 29.9 GO:0035262 gonad morphogenesis(GO:0035262)
0.2 28.5 GO:0006261 DNA-dependent DNA replication(GO:0006261)
4.5 26.8 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
1.3 24.9 GO:0071850 mitotic cell cycle arrest(GO:0071850)
8.0 23.9 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
1.3 22.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.7 20.1 GO:0070933 histone H4 deacetylation(GO:0070933)
0.8 19.9 GO:0042462 eye photoreceptor cell development(GO:0042462)
4.9 19.6 GO:0090235 regulation of metaphase plate congression(GO:0090235)
3.6 17.9 GO:0015671 oxygen transport(GO:0015671)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 173 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 239.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 132.5 GO:0005634 nucleus(GO:0005634)
0.0 90.5 GO:0005654 nucleoplasm(GO:0005654)
0.6 82.0 GO:0032993 protein-DNA complex(GO:0032993)
18.5 55.6 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.4 32.2 GO:0017053 transcriptional repressor complex(GO:0017053)
1.8 32.0 GO:0035102 PRC1 complex(GO:0035102)
7.2 28.8 GO:0008623 CHRAC(GO:0008623)
0.4 27.6 GO:0016459 myosin complex(GO:0016459)
0.2 26.9 GO:0005923 bicellular tight junction(GO:0005923)
0.3 26.2 GO:0016363 nuclear matrix(GO:0016363)
0.3 26.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.4 24.4 GO:0005871 kinesin complex(GO:0005871)
0.0 24.1 GO:0005730 nucleolus(GO:0005730)
2.2 23.7 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.3 23.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
1.8 23.0 GO:0043219 lateral loop(GO:0043219)
4.4 22.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 21.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 21.3 GO:0005815 microtubule organizing center(GO:0005815)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 250 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 174.0 GO:0003677 DNA binding(GO:0003677)
0.3 170.4 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.7 114.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.4 74.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
3.9 73.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
7.4 66.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.4 44.9 GO:0003774 motor activity(GO:0003774)
0.4 31.9 GO:0035064 methylated histone binding(GO:0035064)
1.6 29.7 GO:0070410 co-SMAD binding(GO:0070410)
1.5 28.4 GO:0035497 cAMP response element binding(GO:0035497)
2.4 26.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.1 22.5 GO:0030215 semaphorin receptor binding(GO:0030215)
4.4 22.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
3.6 17.9 GO:0005344 oxygen transporter activity(GO:0005344)
1.0 17.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.6 17.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
2.9 17.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.6 17.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.9 16.9 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
2.4 16.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 53.2 PID_IL12_2PATHWAY IL12-mediated signaling events
0.5 38.7 PID_CMYB_PATHWAY C-MYB transcription factor network
0.4 35.8 PID_E2F_PATHWAY E2F transcription factor network
0.6 29.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.5 25.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.5 23.9 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.3 23.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.3 21.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.6 16.6 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.3 16.3 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.4 15.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.4 15.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
1.1 15.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 14.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.8 12.8 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.3 12.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 12.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.4 11.7 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.3 11.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.3 11.6 PID_NOTCH_PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 83.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.3 45.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3 30.3 REACTOME_MEIOSIS Genes involved in Meiosis
0.9 22.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
1.4 22.1 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.9 17.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.8 17.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.5 16.5 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.4 16.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 15.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.9 15.6 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
1.3 15.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.5 14.5 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
1.6 14.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
1.1 13.6 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.9 12.4 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.3 12.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.4 11.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.3 11.7 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 11.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production