Motif ID: Sox21

Z-value: 0.493


Transcription factors associated with Sox21:

Gene SymbolEntrez IDGene Name
Sox21 ENSMUSG00000061517.7 Sox21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox21mm10_v2_chr14_-_118237016_1182370350.411.1e-02Click!


Activity profile for motif Sox21.

activity profile for motif Sox21


Sorted Z-values histogram for motif Sox21

Sorted Z-values for motif Sox21



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox21

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 108 entries
PromoterScoreRefseqGene SymbolGene Name
chrM_-_14060 2.324 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr7_+_51621830 2.107 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr1_+_109993982 2.084 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr6_+_120666388 1.932 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr10_-_116972609 1.847 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chr12_+_38783503 1.798 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr11_+_69045640 1.667 ENSMUST00000108666.1
ENSMUST00000021277.5
 Aurkb

aurora kinase B

chr1_+_107511416 1.616 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr18_-_34007206 1.564 ENSMUST00000025234.5
 Epb4.1l4a
erythrocyte protein band 4.1-like 4a
chrM_+_14138 1.441 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr2_-_72986716 1.229 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr4_+_116708467 1.110 ENSMUST00000030452.6
 Ccdc163
coiled-coil domain containing 163
chr9_-_73968901 1.061 ENSMUST00000184666.1
 Unc13c
unc-13 homolog C (C. elegans)
chr18_-_15403680 0.880 ENSMUST00000079081.6
 Aqp4
aquaporin 4
chr7_-_25675047 0.857 ENSMUST00000108404.1
ENSMUST00000108405.1
ENSMUST00000079439.3
 Tmem91


transmembrane protein 91


chr19_+_44493472 0.811 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr17_+_47737030 0.787 ENSMUST00000086932.3
 Tfeb
transcription factor EB
chr4_+_139923349 0.772 ENSMUST00000128563.1
 Gm13028
predicted gene 13028
chr3_+_16183177 0.732 ENSMUST00000108345.2
ENSMUST00000108346.2
 Ythdf3

YTH domain family 3

chr8_-_57652993 0.710 ENSMUST00000110316.2
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.1 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 2.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 1.9 GO:0001842 neural fold formation(GO:0001842)
0.2 1.8 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.6 1.7 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.3 1.4 GO:0033762 response to glucagon(GO:0033762)
0.2 1.2 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.1 1.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.2 0.9 GO:0070295 renal water absorption(GO:0070295)
0.2 0.9 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.3 0.8 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.0 0.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.7 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.2 0.6 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 0.6 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0 0.6 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 0.5 GO:0051461 regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 0.4 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)
0.0 0.4 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.4 GO:0032460 negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 GO:0070469 respiratory chain(GO:0070469)
0.1 2.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.5 1.9 GO:0090537 CERF complex(GO:0090537)
0.3 1.7 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 1.4 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 1.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 1.1 GO:0044305 calyx of Held(GO:0044305)
0.1 0.6 GO:0060187 cell pole(GO:0060187)
0.1 0.5 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.4 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.3 GO:0016460 myosin II complex(GO:0016460)
0.1 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.2 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0032797 SMN complex(GO:0032797)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.1 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.3 1.7 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 1.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.4 1.1 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.1 0.9 GO:0015288 porin activity(GO:0015288)
0.3 0.8 GO:0071568 UFM1 transferase activity(GO:0071568)
0.0 0.8 GO:0005109 frizzled binding(GO:0005109)
0.1 0.7 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.7 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 0.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.3 GO:0016594 glycine binding(GO:0016594)
0.1 0.2 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.7 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 0.9 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism