Motif ID: Sox3_Sox10

Z-value: 1.424

Transcription factors associated with Sox3_Sox10:

Gene SymbolEntrez IDGene Name
Sox10 ENSMUSG00000033006.9 Sox10
Sox3 ENSMUSG00000045179.8 Sox3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox10mm10_v2_chr15_-_79164477_79164496-0.261.3e-01Click!
Sox3mm10_v2_chrX_-_60893430_60893440-0.019.8e-01Click!


Activity profile for motif Sox3_Sox10.

activity profile for motif Sox3_Sox10


Sorted Z-values histogram for motif Sox3_Sox10

Sorted Z-values for motif Sox3_Sox10



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox3_Sox10

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_67586675 13.767 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr11_+_67586520 12.829 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr6_+_51432663 10.568 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr2_+_158666690 9.756 ENSMUST00000103116.3
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr12_-_31713873 8.569 ENSMUST00000057783.4
ENSMUST00000174480.2
ENSMUST00000176710.1
 Gpr22


G protein-coupled receptor 22


chr6_+_51432678 8.226 ENSMUST00000160133.1
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr4_+_102254739 7.802 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr6_-_13839916 7.110 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr5_+_66968559 6.836 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chrX_-_167209149 6.506 ENSMUST00000112176.1
 Tmsb4x
thymosin, beta 4, X chromosome
chr1_+_34579693 6.208 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr17_-_68004075 6.193 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr6_-_136171722 6.060 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr16_-_76373014 5.927 ENSMUST00000054178.1
 Nrip1
nuclear receptor interacting protein 1
chr7_+_29309429 5.581 ENSMUST00000137848.1
 Dpf1
D4, zinc and double PHD fingers family 1
chrX_-_143933089 5.400 ENSMUST00000087313.3
 Dcx
doublecortin
chr17_+_55445550 5.375 ENSMUST00000025000.3
 St6gal2
beta galactoside alpha 2,6 sialyltransferase 2
chr11_-_76468396 5.357 ENSMUST00000065028.7
 Abr
active BCR-related gene
chr6_-_99028874 5.289 ENSMUST00000154163.2
 Foxp1
forkhead box P1
chr2_-_64975762 5.271 ENSMUST00000156765.1
 Grb14
growth factor receptor bound protein 14

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 373 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 25.8 GO:0030041 actin filament polymerization(GO:0030041)
1.3 17.6 GO:1901078 negative regulation of relaxation of muscle(GO:1901078)
1.3 12.1 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.3 11.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 10.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
2.1 10.5 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
2.0 10.1 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
1.0 9.9 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.9 9.5 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.6 9.4 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
1.3 8.9 GO:0019532 oxalate transport(GO:0019532)
0.9 8.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.7 7.8 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.2 7.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.5 7.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.4 7.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
1.5 6.2 GO:1904425 negative regulation of GTP binding(GO:1904425)
1.5 6.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
2.0 5.9 GO:0001543 ovarian follicle rupture(GO:0001543)
0.4 5.9 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 22.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.9 22.4 GO:0071565 nBAF complex(GO:0071565)
0.2 21.1 GO:0005884 actin filament(GO:0005884)
0.3 19.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 17.5 GO:0043034 costamere(GO:0043034)
1.6 16.3 GO:0045298 tubulin complex(GO:0045298)
0.0 15.4 GO:0005768 endosome(GO:0005768)
0.1 13.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 13.4 GO:0043204 perikaryon(GO:0043204)
1.3 11.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.6 10.3 GO:1990635 proximal dendrite(GO:1990635)
0.2 10.1 GO:0031941 filamentous actin(GO:0031941)
0.5 8.4 GO:0032279 asymmetric synapse(GO:0032279)
0.0 8.2 GO:0005874 microtubule(GO:0005874)
0.2 7.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 7.1 GO:0000139 Golgi membrane(GO:0000139)
2.3 6.9 GO:0002142 stereocilia ankle link complex(GO:0002142)
0.0 6.3 GO:0005769 early endosome(GO:0005769)
0.4 6.1 GO:0043083 synaptic cleft(GO:0043083)
0.1 5.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 244 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 24.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 21.5 GO:0005096 GTPase activator activity(GO:0005096)
0.1 19.8 GO:0008017 microtubule binding(GO:0008017)
0.5 17.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 16.6 GO:0051015 actin filament binding(GO:0051015)
0.1 13.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.7 12.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.8 11.3 GO:0031005 filamin binding(GO:0031005)
0.1 11.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.4 10.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 9.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.9 9.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 9.0 GO:0003779 actin binding(GO:0003779)
0.0 9.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.8 8.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.3 8.8 GO:0003785 actin monomer binding(GO:0003785)
0.3 8.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 8.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 7.7 GO:0008201 heparin binding(GO:0008201)
0.0 7.7 GO:0004930 G-protein coupled receptor activity(GO:0004930)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.4 PID_LKB1_PATHWAY LKB1 signaling events
0.2 14.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.7 12.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 8.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 7.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 7.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 6.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 6.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 6.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 6.3 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 4.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 4.6 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 4.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 4.4 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 4.3 PID_BMP_PATHWAY BMP receptor signaling
0.1 4.2 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 3.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 3.3 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 2.9 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 2.8 PID_CMYB_PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 19.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.5 12.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 11.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 10.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 10.4 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 9.4 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 9.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 8.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 7.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.4 7.1 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.3 6.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.3 6.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.3 5.9 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 5.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 5.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 5.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 4.7 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 4.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 4.5 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 4.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins