Motif ID: Sox5_Sry

Z-value: 1.839

Transcription factors associated with Sox5_Sry:

Gene SymbolEntrez IDGene Name
Sox5 ENSMUSG00000041540.10 Sox5
Sry ENSMUSG00000069036.3 Sry

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox5mm10_v2_chr6_-_143947092_1439471110.334.3e-02Click!


Activity profile for motif Sox5_Sry.

activity profile for motif Sox5_Sry


Sorted Z-values histogram for motif Sox5_Sry

Sorted Z-values for motif Sox5_Sry



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox5_Sry

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_115824699 20.458 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr3_+_127633134 13.897 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr17_-_70849644 10.925 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr18_-_84086379 9.946 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr1_+_6730051 9.847 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr2_-_60125651 9.828 ENSMUST00000112550.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr4_-_97584612 9.618 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584605 9.312 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_+_109978004 9.182 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr13_-_56252163 8.594 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr6_+_15185456 8.419 ENSMUST00000115472.1
ENSMUST00000115474.1
ENSMUST00000031545.7
ENSMUST00000137628.1
 Foxp2



forkhead box P2



chr10_-_130280218 8.168 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4
chr18_-_62756275 8.011 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr2_+_102658640 7.843 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_+_94044111 7.040 ENSMUST00000132079.1
 Spag9
sperm associated antigen 9
chr6_+_128375456 7.009 ENSMUST00000100926.2
 4933413G19Rik
RIKEN cDNA 4933413G19 gene
chr1_+_6730135 6.704 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr11_-_50292302 6.486 ENSMUST00000059458.4
 Maml1
mastermind like 1 (Drosophila)
chr10_-_128704978 6.423 ENSMUST00000026416.7
ENSMUST00000026415.7
 Cdk2

cyclin-dependent kinase 2

chr4_-_82505707 6.309 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 28.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
2.1 23.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
4.7 19.0 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
2.2 17.4 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
1.3 15.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 12.0 GO:0043488 regulation of mRNA stability(GO:0043488)
3.3 9.9 GO:0060023 soft palate development(GO:0060023)
2.5 9.9 GO:0021603 cranial nerve formation(GO:0021603)
3.0 9.0 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.7 8.4 GO:2000794 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.8 8.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
2.7 8.0 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.1 8.0 GO:0048469 cell maturation(GO:0048469)
1.1 7.8 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.8 7.5 GO:0030035 microspike assembly(GO:0030035)
0.3 7.4 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.4 7.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.5 6.8 GO:0035881 amacrine cell differentiation(GO:0035881)
2.2 6.5 GO:0003162 atrioventricular node development(GO:0003162)
1.3 6.4 GO:0032298 positive regulation of DNA-dependent DNA replication initiation(GO:0032298)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 69.9 GO:0005634 nucleus(GO:0005634)
0.1 22.1 GO:0032993 protein-DNA complex(GO:0032993)
0.1 21.8 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.9 19.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 16.4 GO:0000785 chromatin(GO:0000785)
0.0 14.1 GO:0005815 microtubule organizing center(GO:0005815)
0.2 13.3 GO:0016459 myosin complex(GO:0016459)
0.0 10.6 GO:0005667 transcription factor complex(GO:0005667)
0.1 9.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.6 9.4 GO:0042788 polysomal ribosome(GO:0042788)
0.1 8.6 GO:0072562 blood microparticle(GO:0072562)
0.4 8.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 7.8 GO:0030673 axolemma(GO:0030673)
0.1 7.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 6.8 GO:0044295 axonal growth cone(GO:0044295)
0.0 6.7 GO:0030027 lamellipodium(GO:0030027)
0.6 6.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
1.3 6.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 6.5 GO:0008180 COP9 signalosome(GO:0008180)
2.1 6.4 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 41.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.1 30.6 GO:0008432 JUN kinase binding(GO:0008432)
0.7 26.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.6 25.4 GO:0070888 E-box binding(GO:0070888)
0.1 18.4 GO:0001047 core promoter binding(GO:0001047)
0.3 16.9 GO:0030507 spectrin binding(GO:0030507)
0.3 11.6 GO:0017091 AU-rich element binding(GO:0017091)
0.0 10.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.6 9.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.5 9.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 8.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.4 8.0 GO:0001848 complement binding(GO:0001848)
1.3 7.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.1 7.8 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.4 7.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 7.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 6.5 GO:0042605 peptide antigen binding(GO:0042605)
0.4 6.4 GO:0035173 histone kinase activity(GO:0035173)
1.2 6.1 GO:0043532 angiostatin binding(GO:0043532)
0.5 5.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 28.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 25.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 17.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.2 16.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 10.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 9.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 8.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 7.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.3 6.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.5 6.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 5.1 PID_PLK1_PATHWAY PLK1 signaling events
0.0 4.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 3.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 3.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.5 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 2.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 19.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.7 19.0 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.4 13.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 11.4 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 10.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.6 9.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 9.0 REACTOME_MEIOSIS Genes involved in Meiosis
0.1 8.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 8.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 7.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 6.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 6.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 5.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 5.7 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 5.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 5.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 4.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.3 3.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.3 2.8 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.2 2.8 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis