Motif ID: Sox6_Sox9

Z-value: 0.795

Transcription factors associated with Sox6_Sox9:

Gene SymbolEntrez IDGene Name
Sox6 ENSMUSG00000051910.7 Sox6
Sox9 ENSMUSG00000000567.5 Sox9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox9mm10_v2_chr11_+_112782182_1127822480.401.5e-02Click!
Sox6mm10_v2_chr7_-_115846080_115846112-0.057.7e-01Click!


Activity profile for motif Sox6_Sox9.

activity profile for motif Sox6_Sox9


Sorted Z-values histogram for motif Sox6_Sox9

Sorted Z-values for motif Sox6_Sox9



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox6_Sox9

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84773381 3.292 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr11_-_106715251 3.116 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
 Pecam1



platelet/endothelial cell adhesion molecule 1



chr13_-_97747399 2.820 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr6_+_17463749 2.791 ENSMUST00000115443.1
 Met
met proto-oncogene
chr13_-_97747373 2.779 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr9_-_79718631 2.535 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr2_+_180598219 2.401 ENSMUST00000103059.1
 Col9a3
collagen, type IX, alpha 3
chr9_-_79718518 2.330 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr5_+_66968416 2.147 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr12_+_119945957 2.129 ENSMUST00000058644.8
 Tmem196
transmembrane protein 196
chr9_-_79718720 2.123 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1
chr1_-_155146755 2.093 ENSMUST00000027744.8
 Mr1
major histocompatibility complex, class I-related
chr6_+_65671590 2.011 ENSMUST00000054351.4
 Ndnf
neuron-derived neurotrophic factor
chr18_+_37484955 1.998 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr6_+_86404219 1.974 ENSMUST00000095754.3
ENSMUST00000095753.2
 Tia1

cytotoxic granule-associated RNA binding protein 1

chr8_-_11312731 1.923 ENSMUST00000033898.9
 Col4a1
collagen, type IV, alpha 1
chr6_+_86404336 1.919 ENSMUST00000113713.2
ENSMUST00000113708.1
 Tia1

cytotoxic granule-associated RNA binding protein 1

chr12_-_34528844 1.919 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr17_-_68004075 1.900 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr6_+_86404257 1.873 ENSMUST00000095752.2
ENSMUST00000130967.1
 Tia1

cytotoxic granule-associated RNA binding protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.6 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.9 5.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 4.5 GO:0007416 synapse assembly(GO:0007416)
0.2 3.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.1 3.4 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.8 3.1 GO:0050904 diapedesis(GO:0050904)
0.4 2.8 GO:0044838 cell quiescence(GO:0044838)
0.0 2.3 GO:0007605 sensory perception of sound(GO:0007605)
0.1 2.1 GO:0032620 interleukin-17 production(GO:0032620)
0.1 2.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 2.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) vascular wound healing(GO:0061042)
0.5 1.9 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.3 1.9 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.2 1.9 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.2 1.9 GO:0051923 sulfation(GO:0051923)
0.3 1.8 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.2 1.7 GO:0021546 rhombomere development(GO:0021546)
0.4 1.6 GO:0003357 noradrenergic neuron differentiation(GO:0003357)
0.3 1.6 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.2 1.6 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 7.0 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.6 5.6 GO:0097165 nuclear stress granule(GO:0097165)
0.1 4.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 4.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.6 3.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.6 3.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 2.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.6 GO:0005871 kinesin complex(GO:0005871)
0.6 2.4 GO:0005593 FACIT collagen trimer(GO:0005593)
0.2 2.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 2.0 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.4 1.6 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.4 1.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 1.6 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 1.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 1.2 GO:0044307 dendritic branch(GO:0044307)
0.2 1.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 1.1 GO:0033093 Weibel-Palade body(GO:0033093)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.8 GO:0017091 AU-rich element binding(GO:0017091)
1.3 5.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 3.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.4 3.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.9 2.8 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 2.6 GO:0003777 microtubule motor activity(GO:0003777)
0.3 2.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.6 1.9 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.3 1.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 1.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 1.9 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.9 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.8 GO:0035198 miRNA binding(GO:0035198)
0.2 1.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.5 1.5 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.3 1.5 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 1.5 GO:0050897 cobalt ion binding(GO:0050897)
0.0 1.5 GO:0019903 protein phosphatase binding(GO:0019903)
0.4 1.4 GO:0008131 primary amine oxidase activity(GO:0008131)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.4 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 4.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 3.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 3.3 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 2.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 2.4 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 1.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.7 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.7 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 PID_ATM_PATHWAY ATM pathway
0.0 0.4 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.4 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 5.5 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 3.4 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.2 3.1 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 2.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 2.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.2 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.3 1.9 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.6 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.6 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 1.1 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 0.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA