Motif ID: Sox8

Z-value: 0.390


Transcription factors associated with Sox8:

Gene SymbolEntrez IDGene Name
Sox8 ENSMUSG00000024176.4 Sox8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox8mm10_v2_chr17_-_25570678_25570694-0.617.2e-05Click!


Activity profile for motif Sox8.

activity profile for motif Sox8


Sorted Z-values histogram for motif Sox8

Sorted Z-values for motif Sox8



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox8

PNG image of the network

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Top targets:


Showing 1 to 20 of 47 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_110095937 1.529 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr11_+_97415527 1.360 ENSMUST00000121799.1
Arhgap23
Rho GTPase activating protein 23
chrX_+_134404780 1.045 ENSMUST00000113224.2
ENSMUST00000113226.1
Drp2

dystrophin related protein 2

chr11_+_32286946 0.976 ENSMUST00000101387.3
Hbq1b
hemoglobin, theta 1B
chr18_+_36952621 0.923 ENSMUST00000115661.2
Pcdha2
protocadherin alpha 2
chr11_-_110095974 0.921 ENSMUST00000100287.2
Abca8a
ATP-binding cassette, sub-family A (ABC1), member 8a
chr13_-_66852017 0.908 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr3_+_65109343 0.840 ENSMUST00000159525.1
ENSMUST00000049230.8
Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr18_-_62741387 0.837 ENSMUST00000097557.3
Spink13
serine peptidase inhibitor, Kazal type 13
chr13_+_93304799 0.806 ENSMUST00000080127.5
Homer1
homer homolog 1 (Drosophila)
chrX_-_162643629 0.781 ENSMUST00000112334.1
Reps2
RALBP1 associated Eps domain containing protein 2
chrX_-_162643575 0.763 ENSMUST00000101102.1
Reps2
RALBP1 associated Eps domain containing protein 2
chr13_-_19395728 0.760 ENSMUST00000039694.7
Stard3nl
STARD3 N-terminal like
chr13_-_66227573 0.680 ENSMUST00000167981.2
Gm10772
predicted gene 10772
chr17_+_70561739 0.575 ENSMUST00000097288.2
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr4_+_43401232 0.536 ENSMUST00000125399.1
Rusc2
RUN and SH3 domain containing 2
chr19_+_24875679 0.497 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr14_-_49783327 0.477 ENSMUST00000118129.1
ENSMUST00000036972.6
3632451O06Rik

RIKEN cDNA 3632451O06 gene

chr13_+_93304066 0.421 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr3_-_8667033 0.385 ENSMUST00000042412.3
Hey1
hairy/enhancer-of-split related with YRPW motif 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 0.8 GO:0060467 negative regulation of fertilization(GO:0060467)
0.1 0.8 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.6 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.5 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.4 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.1 0.3 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0 0.3 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.2 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.2 GO:2001184 regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.2 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.1 GO:0006553 lysine metabolic process(GO:0006553)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0043034 costamere(GO:0043034)
0.1 0.8 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.8 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.5 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.3 GO:0010369 chromocenter(GO:0010369)
0.0 0.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:1990357 terminal web(GO:1990357)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 1.2 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.8 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.5 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.4 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.3 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.0 0.1 GO:0032795 heterotrimeric G-protein binding(GO:0032795)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions