Motif ID: Sp1
Z-value: 1.620
Transcription factors associated with Sp1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Sp1 | ENSMUSG00000001280.6 | Sp1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sp1 | mm10_v2_chr15_+_102406143_102406380 | 0.14 | 4.0e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 1,167 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 24.0 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 1.4 | 22.1 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.5 | 20.7 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.3 | 13.8 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.8 | 13.6 | GO:0009950 | dorsal/ventral axis specification(GO:0009950) |
| 1.6 | 13.2 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.6 | 13.2 | GO:0046033 | AMP metabolic process(GO:0046033) |
| 1.6 | 13.0 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.6 | 13.0 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 1.1 | 12.5 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 3.0 | 12.1 | GO:0044268 | multicellular organismal protein metabolic process(GO:0044268) |
| 1.3 | 11.9 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 2.9 | 11.7 | GO:2000525 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) |
| 2.3 | 11.4 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.8 | 11.3 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 1.2 | 10.9 | GO:2000467 | positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 1.5 | 10.8 | GO:0046549 | retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 1.5 | 10.7 | GO:0051775 | response to redox state(GO:0051775) |
| 3.5 | 10.4 | GO:0048687 | positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) |
| 0.7 | 9.9 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 364 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 202.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.3 | 52.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 40.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.3 | 27.9 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.3 | 27.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 26.5 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.1 | 24.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 22.7 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.3 | 17.2 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.9 | 16.5 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 14.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.2 | 14.5 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 1.0 | 13.9 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.4 | 13.6 | GO:0044298 | cell body membrane(GO:0044298) |
| 0.2 | 13.6 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.6 | 13.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 12.6 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.5 | 11.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 1.9 | 11.1 | GO:0016011 | dystroglycan complex(GO:0016011) |
| 0.3 | 10.0 | GO:0031231 | intrinsic component of peroxisomal membrane(GO:0031231) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 631 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 41.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.3 | 24.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.6 | 20.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.5 | 20.4 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 1.0 | 18.1 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 1.1 | 18.0 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.1 | 16.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.6 | 15.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.6 | 15.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.2 | 14.7 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 14.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.4 | 13.9 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.3 | 13.7 | GO:0015485 | cholesterol binding(GO:0015485) |
| 1.0 | 13.5 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.6 | 12.9 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.3 | 11.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.0 | 11.5 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 1.9 | 11.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.7 | 11.1 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 3.7 | 11.0 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 117 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 44.4 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.5 | 32.6 | PID_SHP2_PATHWAY | SHP2 signaling |
| 0.2 | 27.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 26.2 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.6 | 19.1 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.4 | 18.4 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.9 | 15.9 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.4 | 15.0 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.5 | 13.9 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.4 | 11.9 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 10.5 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.7 | 10.3 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
| 0.6 | 10.1 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.4 | 9.9 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.2 | 9.9 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.4 | 9.8 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.4 | 9.7 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.3 | 9.6 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 1.4 | 9.5 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
| 0.4 | 8.7 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 193 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 44.1 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.6 | 22.3 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.6 | 19.8 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 18.8 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 15.3 | REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.2 | 15.0 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.7 | 14.3 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.9 | 13.6 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.4 | 13.6 | REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES | Genes involved in MAPK targets/ Nuclear events mediated by MAP kinases |
| 0.3 | 12.5 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.8 | 11.8 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.3 | 11.5 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.5 | 10.9 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.3 | 10.9 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.5 | 10.5 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.2 | 10.1 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 9.8 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
| 0.3 | 9.7 | REACTOME_GAB1_SIGNALOSOME | Genes involved in GAB1 signalosome |
| 0.3 | 9.4 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 9.2 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
