Motif ID: Sp100

Z-value: 2.535


Transcription factors associated with Sp100:

Gene SymbolEntrez IDGene Name
Sp100 ENSMUSG00000026222.10 Sp100

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp100mm10_v2_chr1_+_85650044_856500520.153.9e-01Click!


Activity profile for motif Sp100.

activity profile for motif Sp100


Sorted Z-values histogram for motif Sp100

Sorted Z-values for motif Sp100



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp100

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3023547 37.866 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3013140 37.497 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr14_-_19418930 31.202 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr2_-_98667264 31.141 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3025417 30.532 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3017408 28.459 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3004457 26.327 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3018753 25.779 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3027439 23.279 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3000922 23.265 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3036877 21.337 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3015654 20.070 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr14_+_65806066 11.528 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr3_+_135212557 10.332 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr8_-_4779513 8.265 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr14_-_67715585 7.099 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr13_-_23762378 5.421 ENSMUST00000091701.2
 Hist1h3a
histone cluster 1, H3a
chr2_-_129297205 5.379 ENSMUST00000052708.6
 Ckap2l
cytoskeleton associated protein 2-like
chr14_+_73237891 5.369 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr10_-_42583628 4.777 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.2 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
1.7 10.3 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.6 8.8 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.3 8.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.8 5.5 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.3 5.4 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
1.0 4.8 GO:0021764 amygdala development(GO:0021764)
0.5 4.8 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.1 4.8 GO:0035307 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.0 4.6 GO:0007059 chromosome segregation(GO:0007059)
0.0 4.5 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 4.3 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.4 3.8 GO:0048102 autophagic cell death(GO:0048102)
0.0 3.8 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.1 3.7 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.2 3.6 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0 3.2 GO:0006635 fatty acid beta-oxidation(GO:0006635)
1.0 3.0 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.9 2.8 GO:0042097 interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.5 2.8 GO:0035166 post-embryonic hemopoiesis(GO:0035166)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 188.6 GO:0005575 cellular_component(GO:0005575)
0.8 10.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) mitotic spindle midzone(GO:1990023)
0.3 9.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 8.8 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 5.9 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 5.6 GO:0072686 mitotic spindle(GO:0072686)
0.1 4.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.7 4.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 4.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 4.1 GO:0005876 spindle microtubule(GO:0005876)
0.1 4.0 GO:0016459 myosin complex(GO:0016459)
0.1 3.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.9 3.6 GO:0043293 apoptosome(GO:0043293)
0.1 3.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 3.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.6 2.8 GO:0032437 cuticular plate(GO:0032437)
0.1 2.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 2.3 GO:0005814 centriole(GO:0005814)
0.0 2.1 GO:0070469 respiratory chain(GO:0070469)
0.6 1.9 GO:0031417 NatC complex(GO:0031417)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 171.1 GO:0003674 molecular_function(GO:0003674)
0.1 13.6 GO:0003774 motor activity(GO:0003774)
2.1 10.3 GO:0043515 kinetochore binding(GO:0043515)
0.2 9.7 GO:0042169 SH2 domain binding(GO:0042169)
0.0 9.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 5.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.8 5.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.3 5.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
1.6 4.8 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 4.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 4.6 GO:0004386 helicase activity(GO:0004386)
0.2 4.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.9 3.7 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 3.4 GO:0042393 histone binding(GO:0042393)
0.3 3.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.9 2.8 GO:0071723 lipopeptide binding(GO:0071723)
0.1 2.8 GO:0035497 cAMP response element binding(GO:0035497)
0.0 2.7 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.5 2.3 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 2.3 GO:0071855 neuropeptide receptor binding(GO:0071855)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.1 PID_PLK1_PATHWAY PLK1 signaling events
0.1 8.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 5.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.5 4.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 2.4 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 1.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.4 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 1.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.2 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.7 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.2 7.9 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.6 5.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.5 4.8 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 4.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.8 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 3.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 2.7 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.3 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.3 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 2.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.8 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 1.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.4 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.3 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.2 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle