Motif ID: Spdef

Z-value: 0.523


Transcription factors associated with Spdef:

Gene SymbolEntrez IDGene Name
Spdef ENSMUSG00000024215.7 Spdef

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spdefmm10_v2_chr17_-_27728889_27728956-0.163.4e-01Click!


Activity profile for motif Spdef.

activity profile for motif Spdef


Sorted Z-values histogram for motif Spdef

Sorted Z-values for motif Spdef



Network of associatons between targets according to the STRING database.



First level regulatory network of Spdef

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_58813359 2.316 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr14_+_28511344 1.426 ENSMUST00000112272.1
 Wnt5a
wingless-related MMTV integration site 5A
chr15_-_89170688 1.298 ENSMUST00000060808.9
 Plxnb2
plexin B2
chr9_+_65908967 1.270 ENSMUST00000034949.3
ENSMUST00000154589.1
 Csnk1g1

casein kinase 1, gamma 1

chr9_+_80165079 1.263 ENSMUST00000184480.1
 Myo6
myosin VI
chr9_+_80165013 1.070 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr9_+_30427329 1.008 ENSMUST00000164099.1
 Snx19
sorting nexin 19
chr2_-_167492826 0.994 ENSMUST00000109211.2
ENSMUST00000057627.9
 Spata2

spermatogenesis associated 2

chr3_-_90243073 0.962 ENSMUST00000107369.1
 Creb3l4
cAMP responsive element binding protein 3-like 4
chr15_-_99820072 0.944 ENSMUST00000109024.2
 Lima1
LIM domain and actin binding 1
chr13_-_21531032 0.941 ENSMUST00000156674.2
ENSMUST00000110481.2
 Zkscan8

zinc finger with KRAB and SCAN domains 8

chr12_-_102878406 0.868 ENSMUST00000045652.6
 Btbd7
BTB (POZ) domain containing 7
chr9_-_65908676 0.852 ENSMUST00000119245.1
ENSMUST00000134338.1
ENSMUST00000179395.1
 Trip4


thyroid hormone receptor interactor 4


chr18_+_34861200 0.827 ENSMUST00000165033.1
 Egr1
early growth response 1
chr10_+_17723220 0.733 ENSMUST00000038107.7
 Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr3_-_84582616 0.730 ENSMUST00000143514.1
 Arfip1
ADP-ribosylation factor interacting protein 1
chrX_+_101254528 0.722 ENSMUST00000062000.4
 Foxo4
forkhead box O4
chr14_+_54254124 0.705 ENSMUST00000180359.1
 Abhd4
abhydrolase domain containing 4
chr13_-_21531084 0.699 ENSMUST00000045228.5
 Zkscan8
zinc finger with KRAB and SCAN domains 8
chr4_-_107923519 0.686 ENSMUST00000106719.1
ENSMUST00000106720.2
ENSMUST00000131644.1
ENSMUST00000030345.8
 Cpt2



carnitine palmitoyltransferase 2




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.3 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.5 1.4 GO:0061349 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
0.1 1.3 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 1.3 GO:2001222 regulation of neuron migration(GO:2001222)
0.3 1.2 GO:0044565 dendritic cell proliferation(GO:0044565)
0.1 1.2 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 1.1 GO:0060749 mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377)
0.3 1.0 GO:0019085 early viral transcription(GO:0019085)
0.1 1.0 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.3 0.9 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
0.1 0.9 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.0 0.9 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.9 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.3 0.8 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.2 0.8 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.1 0.8 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.8 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743)
0.2 0.7 GO:0061428 embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.1 0.7 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.1 0.7 GO:0070317 negative regulation of smooth muscle cell differentiation(GO:0051151) negative regulation of G0 to G1 transition(GO:0070317)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0001650 fibrillar center(GO:0001650)
0.1 2.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 1.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 1.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.8 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.8 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.6 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.1 0.6 GO:0008623 CHRAC(GO:0008623)
0.1 0.6 GO:0000322 storage vacuole(GO:0000322)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.5 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.4 GO:1990130 Iml1 complex(GO:1990130)
0.1 0.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.4 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.4 GO:0032433 filopodium tip(GO:0032433)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0003774 motor activity(GO:0003774)
0.5 1.4 GO:0005110 frizzled-2 binding(GO:0005110)
0.1 1.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.2 1.0 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0 1.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.9 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.9 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 0.8 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2 0.8 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 0.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.7 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.7 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.7 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.7 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.7 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.7 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.2 0.6 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 1.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.8 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.4 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.3 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.3 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.3 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.3 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.1 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.0 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.0 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.8 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 0.7 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.5 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.2 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.2 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.2 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.1 REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR Genes involved in Thromboxane signalling through TP receptor