Motif ID: Spib

Z-value: 1.947


Transcription factors associated with Spib:

Gene SymbolEntrez IDGene Name
Spib ENSMUSG00000008193.7 Spib



Activity profile for motif Spib.

activity profile for motif Spib


Sorted Z-values histogram for motif Spib

Sorted Z-values for motif Spib



Network of associatons between targets according to the STRING database.



First level regulatory network of Spib

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66812593 33.675 ENSMUST00000100572.3
 Sla
src-like adaptor
chr4_-_136898803 14.105 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr4_-_136886187 12.526 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr4_-_136892867 12.424 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr16_+_41532851 12.389 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr6_+_137410721 11.964 ENSMUST00000167002.1
 Ptpro
protein tyrosine phosphatase, receptor type, O
chr1_-_171059390 10.559 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr3_-_87263518 9.538 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr10_+_81257277 9.253 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr1_-_171234290 9.201 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr5_+_81021202 8.804 ENSMUST00000117253.1
ENSMUST00000120128.1
 Lphn3

latrophilin 3

chr17_-_68004075 7.430 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr17_-_67950908 7.412 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr4_+_130913120 7.357 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr3_-_87263703 7.295 ENSMUST00000146512.1
 Fcrls
Fc receptor-like S, scavenger receptor
chr16_-_22439719 7.285 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr7_-_19118357 7.232 ENSMUST00000141380.1
 Gm4969
predicted gene 4969
chr2_+_121357714 7.207 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr15_-_37458523 7.059 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr2_+_14229390 6.957 ENSMUST00000028045.2
 Mrc1
mannose receptor, C type 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 51.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.8 39.1 GO:0006958 complement activation, classical pathway(GO:0006958)
7.5 22.6 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
3.7 14.8 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.5 12.4 GO:0035641 locomotory exploration behavior(GO:0035641)
2.4 12.0 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.1 11.5 GO:0032091 negative regulation of protein binding(GO:0032091)
0.2 11.3 GO:0071277 cellular response to calcium ion(GO:0071277)
1.6 9.8 GO:0032796 uropod organization(GO:0032796)
1.5 9.2 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
2.0 8.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 7.4 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
1.5 7.3 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 7.0 GO:0071353 cellular response to interleukin-4(GO:0071353)
2.3 6.9 GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
1.4 6.8 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 6.1 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.2 5.7 GO:0030903 notochord development(GO:0030903)
1.8 5.3 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553) regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.2 5.2 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 46.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5 37.1 GO:0005581 collagen trimer(GO:0005581)
0.2 36.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 14.4 GO:0030054 cell junction(GO:0030054)
0.1 13.6 GO:0044455 mitochondrial membrane part(GO:0044455)
0.1 12.4 GO:0031225 anchored component of membrane(GO:0031225)
0.2 12.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.9 9.8 GO:0032426 stereocilium tip(GO:0032426)
0.0 9.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 7.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 6.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 5.6 GO:0097449 astrocyte projection(GO:0097449)
0.0 5.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 5.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
1.3 5.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.1 5.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 4.5 GO:0009986 cell surface(GO:0009986)
0.2 4.3 GO:0071564 npBAF complex(GO:0071564)
0.8 4.2 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.2 3.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 51.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
4.8 28.9 GO:0019864 immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864)
0.1 23.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 12.6 GO:0042803 protein homodimerization activity(GO:0042803)
3.1 12.4 GO:0004111 creatine kinase activity(GO:0004111)
0.3 10.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.9 9.8 GO:0032036 myosin heavy chain binding(GO:0032036)
1.3 9.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.6 8.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.5 7.8 GO:0005537 mannose binding(GO:0005537)
0.2 7.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 6.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 6.1 GO:0005504 fatty acid binding(GO:0005504)
0.0 5.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.3 5.3 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) A2A adenosine receptor binding(GO:0031687) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.2 5.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 5.3 GO:0030246 carbohydrate binding(GO:0030246)
0.4 5.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 5.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 4.5 GO:0042043 neurexin family protein binding(GO:0042043)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 36.2 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 35.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 22.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.4 17.7 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.4 16.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.3 10.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 8.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 6.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 5.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 5.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 5.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 4.6 PID_ARF_3PATHWAY Arf1 pathway
0.1 4.1 ST_ADRENERGIC Adrenergic Pathway
0.1 3.7 PID_BCR_5PATHWAY BCR signaling pathway
0.1 3.6 SIG_CHEMOTAXIS Genes related to chemotaxis
0.1 3.1 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 2.7 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.1 1.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 1.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.5 39.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 23.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 11.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.8 10.1 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.7 9.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 7.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 7.0 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 6.7 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 6.5 REACTOME_SIGNALING_BY_ERBB2 Genes involved in Signaling by ERBB2
0.3 6.3 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 5.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 5.3 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.2 4.8 REACTOME_SIGNALING_BY_SCF_KIT Genes involved in Signaling by SCF-KIT
0.1 4.8 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 4.3 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.4 4.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 4.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 3.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 3.6 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 3.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines