Motif ID: Spic

Z-value: 1.450


Transcription factors associated with Spic:

Gene SymbolEntrez IDGene Name
Spic ENSMUSG00000004359.10 Spic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spicmm10_v2_chr10_-_88683021_88683025-0.067.1e-01Click!


Activity profile for motif Spic.

activity profile for motif Spic


Sorted Z-values histogram for motif Spic

Sorted Z-values for motif Spic



Network of associatons between targets according to the STRING database.



First level regulatory network of Spic

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_136892867 15.524 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr4_-_136886187 12.472 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr1_-_171234290 10.955 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr6_+_5725639 10.205 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr1_-_56978534 9.413 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr3_+_95526777 8.358 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr6_+_137410721 7.643 ENSMUST00000167002.1
 Ptpro
protein tyrosine phosphatase, receptor type, O
chr15_-_66812593 7.638 ENSMUST00000100572.3
 Sla
src-like adaptor
chr4_+_130913120 7.372 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr4_+_130913264 6.719 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr19_+_12460749 5.897 ENSMUST00000081035.7
 Mpeg1
macrophage expressed gene 1
chr1_-_170976112 5.171 ENSMUST00000027966.7
ENSMUST00000081103.5
ENSMUST00000159688.1
 Fcgr2b


Fc receptor, IgG, low affinity IIb


chr10_-_117282262 4.825 ENSMUST00000092163.7
 Lyz2
lysozyme 2
chr14_+_57524734 4.499 ENSMUST00000089494.4
 Il17d
interleukin 17D
chr12_-_4592927 4.471 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr8_-_122432924 4.414 ENSMUST00000017604.8
 Cyba
cytochrome b-245, alpha polypeptide
chr1_-_171059390 4.410 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr11_+_78324200 4.060 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr11_-_106715251 3.884 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
 Pecam1



platelet/endothelial cell adhesion molecule 1



chr14_+_80000292 3.857 ENSMUST00000088735.3
 Olfm4
olfactomedin 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 168 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.8 17.3 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
2.0 13.8 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.6 12.5 GO:0006958 complement activation, classical pathway(GO:0006958)
2.4 12.1 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.1 11.0 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.9 10.2 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.6 9.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 8.4 GO:0010447 response to acidic pH(GO:0010447)
0.1 7.6 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.1 6.8 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.9 5.5 GO:0032796 uropod organization(GO:0032796)
1.7 5.2 GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
1.6 4.8 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
1.5 4.5 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.1 4.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.4 4.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.0 3.9 GO:0050904 diapedesis(GO:0050904)
0.1 3.9 GO:0042255 ribosome assembly(GO:0042255)
1.3 3.8 GO:0060785 regulation of apoptosis involved in tissue homeostasis(GO:0060785)
0.2 3.8 GO:0000338 protein deneddylation(GO:0000338)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 28.2 GO:0005581 collagen trimer(GO:0005581)
0.1 25.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 11.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
3.4 10.2 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.1 8.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 7.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 7.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 6.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
1.1 5.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.5 5.5 GO:0032426 stereocilium tip(GO:0032426)
0.2 5.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.4 5.0 GO:0042581 specific granule(GO:0042581)
1.0 4.8 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.9 4.5 GO:1990745 EARP complex(GO:1990745)
0.2 4.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.8 3.9 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 3.8 GO:0008180 COP9 signalosome(GO:0008180)
0.7 3.7 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 3.7 GO:0031209 SCAR complex(GO:0031209)
0.1 3.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 22.5 GO:0019864 immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864)
0.6 10.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 8.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 8.8 GO:0043394 proteoglycan binding(GO:0043394)
0.2 7.6 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 7.6 GO:0019905 syntaxin binding(GO:0019905)
0.0 7.5 GO:0042803 protein homodimerization activity(GO:0042803)
1.0 6.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.6 6.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.4 5.5 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.5 5.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.9 5.2 GO:0016936 galactoside binding(GO:0016936)
0.0 4.9 GO:0005525 GTP binding(GO:0005525)
1.6 4.8 GO:0003796 lysozyme activity(GO:0003796)
0.2 4.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 4.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.7 4.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 3.9 GO:0019903 protein phosphatase binding(GO:0019903)
1.3 3.8 GO:0072541 peroxynitrite reductase activity(GO:0072541)
1.2 3.7 GO:0016901 glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 32.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 24.1 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.2 9.2 PID_RAC1_PATHWAY RAC1 signaling pathway
0.2 9.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 7.3 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 7.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 6.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 5.5 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 4.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 4.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.6 3.9 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 3.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 2.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 2.0 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 1.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.8 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 1.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.3 ST_ADRENERGIC Adrenergic Pathway
0.0 0.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 28.0 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 15.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.8 11.0 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
2.8 8.4 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 8.0 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 6.7 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 5.7 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.3 5.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 4.5 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.1 4.1 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.2 3.9 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 3.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 3.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 3.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 3.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 3.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 3.1 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 3.0 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 2.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 2.8 REACTOME_POL_SWITCHING Genes involved in Polymerase switching