Motif ID: Srf

Z-value: 1.004


Transcription factors associated with Srf:

Gene SymbolEntrez IDGene Name
Srf ENSMUSG00000015605.5 Srf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srfmm10_v2_chr17_-_46556158_46556188-0.202.4e-01Click!


Activity profile for motif Srf.

activity profile for motif Srf


Sorted Z-values histogram for motif Srf

Sorted Z-values for motif Srf



Network of associatons between targets according to the STRING database.



First level regulatory network of Srf

PNG image of the network

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Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 7.235 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr4_+_43957678 3.372 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr4_+_43957401 3.144 ENSMUST00000030202.7
 Glipr2
GLI pathogenesis-related 2
chr14_+_5071040 2.976 ENSMUST00000163719.1
 Gm8281
predicted gene, 8281
chr14_+_4726775 2.732 ENSMUST00000165619.1
 Gm3252
predicted gene 3252
chr14_+_4415448 2.708 ENSMUST00000168866.1
 Gm3164
predicted gene 3164
chr14_+_3652030 2.618 ENSMUST00000167430.1
 Gm3020
predicted gene 3020
chr14_+_3412614 2.590 ENSMUST00000170123.1
 Gm10409
predicted gene 10409
chr14_-_6889962 2.514 ENSMUST00000171906.1
 Gm3667
predicted gene 3667
chr14_+_4334763 2.480 ENSMUST00000165466.1
 2610042L04Rik
RIKEN cDNA 2610042L04 gene
chr10_-_120899067 2.430 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr14_+_3332627 2.428 ENSMUST00000177786.1
 Gm2956
predicted gene 2956
chr14_+_4182576 2.404 ENSMUST00000164512.1
 Gm2974
predicted gene 2974
chr14_+_3049285 2.354 ENSMUST00000166494.1
 Gm2897
predicted gene 2897
chr14_-_7568566 2.324 ENSMUST00000163790.1
 Gm3558
predicted gene 3558
chr14_+_3572023 2.282 ENSMUST00000178728.1
 Gm3005
predicted gene 3005
chr14_-_5961745 2.172 ENSMUST00000163885.1
 Gm3248
predicted gene 3248
chr14_-_6038209 2.155 ENSMUST00000164139.1
 Gm8206
predicted gene 8206
chr14_-_7027449 2.153 ENSMUST00000170738.2
 Gm10406
predicted gene 10406
chr14_-_5389049 2.132 ENSMUST00000177986.1
 Gm3500
predicted gene 3500

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 5.0 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.4 3.0 GO:1902302 regulation of potassium ion export(GO:1902302)
0.3 2.7 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 2.6 GO:0045214 sarcomere organization(GO:0045214)
0.6 2.5 GO:0060025 regulation of synaptic activity(GO:0060025)
0.6 2.4 GO:0030091 protein repair(GO:0030091)
0.7 2.1 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.1 2.1 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.3 2.0 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 1.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.9 GO:0001706 endoderm formation(GO:0001706)
0.1 1.8 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 1.6 GO:0001553 luteinization(GO:0001553)
0.5 1.5 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.1 1.5 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.7 1.4 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.2 1.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 1.1 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.0 1.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0000139 Golgi membrane(GO:0000139)
0.4 2.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 2.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.4 1.8 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 1.5 GO:0005902 microvillus(GO:0005902)
0.0 1.3 GO:0043034 costamere(GO:0043034)
0.2 1.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 1.2 GO:0042629 mast cell granule(GO:0042629)
0.1 0.9 GO:0000124 SAGA complex(GO:0000124)
0.1 0.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.7 GO:0031430 M band(GO:0031430)
0.1 0.6 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.1 0.6 GO:0035976 AP1 complex(GO:0035976)
0.0 0.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 0.5 GO:0005927 muscle tendon junction(GO:0005927)
0.0 0.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 3.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 2.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.7 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.4 2.4 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 2.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 2.0 GO:0048495 Roundabout binding(GO:0048495)
0.2 1.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.4 1.8 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 1.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 1.4 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 1.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.1 GO:0071837 HMG box domain binding(GO:0071837)
0.3 1.0 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 1.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.9 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 0.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.8 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.5 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 1.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.8 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.6 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.5 PID_IL3_PATHWAY IL3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 1.9 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.1 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.8 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.6 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression