Motif ID: Stat1

Z-value: 0.497


Transcription factors associated with Stat1:

Gene SymbolEntrez IDGene Name
Stat1 ENSMUSG00000026104.8 Stat1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat1mm10_v2_chr1_+_52119438_52119499-0.454.8e-03Click!


Activity profile for motif Stat1.

activity profile for motif Stat1


Sorted Z-values histogram for motif Stat1

Sorted Z-values for motif Stat1



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat1

PNG image of the network

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Top targets:


Showing 1 to 20 of 166 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78499087 3.934 ENSMUST00000017488.4
 Vtn
vitronectin
chr15_-_93519499 2.797 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr12_+_74297474 2.418 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr17_-_68004075 2.249 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr11_+_101245996 2.032 ENSMUST00000129680.1
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr3_-_80802789 1.997 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr8_-_105568298 1.851 ENSMUST00000005849.5
 Agrp
agouti related protein
chr15_-_37459327 1.818 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr4_-_136886187 1.785 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr15_-_37458523 1.735 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr4_-_64046925 1.674 ENSMUST00000107377.3
 Tnc
tenascin C
chr9_+_20868628 1.513 ENSMUST00000043911.7
 A230050P20Rik
RIKEN cDNA A230050P20 gene
chr7_-_78577771 1.476 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chrX_-_61185558 1.447 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr4_+_43401232 1.176 ENSMUST00000125399.1
 Rusc2
RUN and SH3 domain containing 2
chr11_+_82035569 1.095 ENSMUST00000000193.5
 Ccl2
chemokine (C-C motif) ligand 2
chr7_+_45783686 1.041 ENSMUST00000118564.1
ENSMUST00000133428.1
 Lmtk3

lemur tyrosine kinase 3

chr3_-_10440054 1.035 ENSMUST00000099223.4
ENSMUST00000029047.6
 Snx16

sorting nexin 16

chr17_-_45592569 1.000 ENSMUST00000163492.1
 Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr7_+_24134148 0.987 ENSMUST00000056549.7
 Zfp235
zinc finger protein 235

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.9 GO:0097421 liver regeneration(GO:0097421)
0.0 3.7 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 3.2 GO:0034340 response to type I interferon(GO:0034340)
0.9 2.8 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.6 2.2 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.3 2.0 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 2.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 2.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 1.9 GO:0008343 adult feeding behavior(GO:0008343)
0.3 1.8 GO:0015862 uridine transport(GO:0015862)
0.4 1.7 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.4 1.6 GO:0046967 cytosol to ER transport(GO:0046967)
0.2 1.6 GO:0048251 elastic fiber assembly(GO:0048251)
0.5 1.5 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.2 1.5 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
0.1 1.3 GO:0016198 axon choice point recognition(GO:0016198)
0.2 1.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 1.1 GO:2000427 eosinophil chemotaxis(GO:0048245) T cell extravasation(GO:0072683) positive regulation of apoptotic cell clearance(GO:2000427)
0.1 1.0 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 1.0 GO:0071470 cellular response to osmotic stress(GO:0071470)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 5.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 3.4 GO:0005581 collagen trimer(GO:0005581)
0.4 2.0 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 2.0 GO:0032279 asymmetric synapse(GO:0032279)
0.1 1.7 GO:0005614 interstitial matrix(GO:0005614)
0.2 1.6 GO:0042825 TAP complex(GO:0042825)
0.4 1.1 GO:0044299 C-fiber(GO:0044299)
0.1 1.0 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.6 GO:0031673 H zone(GO:0031673)
0.1 0.6 GO:0000322 storage vacuole(GO:0000322)
0.1 0.6 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.6 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.1 0.5 GO:1902636 kinociliary basal body(GO:1902636)
0.1 0.4 GO:0070876 SOSS complex(GO:0070876)
0.0 0.4 GO:0005916 fascia adherens(GO:0005916)
0.0 0.4 GO:0044300 cerebellar mossy fiber(GO:0044300)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.9 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 3.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.4 2.0 GO:0097643 amylin receptor activity(GO:0097643)
0.3 2.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.5 1.9 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 1.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.8 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 1.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 1.7 GO:0019962 interferon receptor activity(GO:0004904) type I interferon receptor activity(GO:0004905) type I interferon binding(GO:0019962)
0.3 1.7 GO:0045545 syndecan binding(GO:0045545)
0.4 1.6 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.4 1.6 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.3 1.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.4 1.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 0.9 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.9 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.8 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 1.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 1.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.4 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.4 PID_SHP2_PATHWAY SHP2 signaling
0.0 1.1 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 1.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.7 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.1 0.6 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.2 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 3.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 3.0 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 2.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 2.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 2.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.8 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.7 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 1.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.4 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.1 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.0 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.8 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 0.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.6 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.5 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.5 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.4 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor