Motif ID: Stat2

Z-value: 2.422


Transcription factors associated with Stat2:

Gene SymbolEntrez IDGene Name
Stat2 ENSMUSG00000040033.9 Stat2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat2mm10_v2_chr10_+_128270546_1282705770.076.6e-01Click!


Activity profile for motif Stat2.

activity profile for motif Stat2


Sorted Z-values histogram for motif Stat2

Sorted Z-values for motif Stat2



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_173942445 19.932 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr7_-_141010759 16.806 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr12_+_103434211 16.235 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr4_-_154636831 14.119 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr6_+_121245903 13.178 ENSMUST00000032198.9
 Usp18
ubiquitin specific peptidase 18
chr3_-_107760221 13.014 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr1_-_156674290 12.439 ENSMUST00000079625.4
 Tor3a
torsin family 3, member A
chr16_+_42907563 11.273 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr14_+_28511344 10.344 ENSMUST00000112272.1
 Wnt5a
wingless-related MMTV integration site 5A
chr16_+_43363855 9.818 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr19_+_55741810 9.462 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr6_-_39118211 9.383 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr2_-_51972990 8.647 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor

chr16_+_43235856 8.500 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr16_+_43364145 8.396 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr15_+_79892397 8.202 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
 Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr8_-_71537402 8.090 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr11_+_119393060 7.675 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr16_-_22439719 7.673 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr15_+_79892436 7.284 ENSMUST00000175752.1
ENSMUST00000176325.1
 Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 53.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
1.1 37.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.8 23.8 GO:0035458 cellular response to interferon-beta(GO:0035458)
3.6 17.8 GO:0060809 mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.4 16.2 GO:0046825 regulation of protein export from nucleus(GO:0046825)
2.6 15.5 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
1.8 14.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
4.4 13.2 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
1.6 13.2 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
3.1 12.5 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
1.9 11.3 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
1.2 9.5 GO:0048625 myoblast fate commitment(GO:0048625)
1.8 9.0 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
1.8 8.8 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
2.9 8.6 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
2.0 8.1 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.5 7.7 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.7 7.7 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 7.1 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
1.7 6.8 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 103.3 GO:0005634 nucleus(GO:0005634)
0.1 33.2 GO:0045177 apical part of cell(GO:0045177)
0.2 24.2 GO:0016363 nuclear matrix(GO:0016363)
0.0 18.2 GO:0005730 nucleolus(GO:0005730)
0.4 16.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.4 15.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 14.1 GO:0016235 aggresome(GO:0016235)
4.3 13.0 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 12.9 GO:0005923 bicellular tight junction(GO:0005923)
0.0 12.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.7 10.5 GO:0044754 autolysosome(GO:0044754)
1.1 9.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 7.1 GO:0005615 extracellular space(GO:0005615)
0.7 6.8 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.4 6.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 5.2 GO:0043235 receptor complex(GO:0043235)
0.0 5.1 GO:0043197 dendritic spine(GO:0043197)
0.8 4.9 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.4 4.7 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.0 4.3 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 57.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 24.2 GO:0019843 rRNA binding(GO:0019843)
0.2 21.6 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 20.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.9 19.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.7 16.2 GO:0005521 lamin binding(GO:0005521)
3.9 15.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 13.4 GO:0005525 GTP binding(GO:0005525)
0.1 13.0 GO:0008083 growth factor activity(GO:0008083)
0.1 12.5 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 12.4 GO:0016836 hydro-lyase activity(GO:0016836)
3.4 10.3 GO:0005110 frizzled-2 binding(GO:0005110)
0.5 9.5 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
2.2 8.8 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 8.6 GO:0003712 transcription cofactor activity(GO:0003712)
0.7 8.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 6.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.8 6.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
2.1 6.4 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.1 6.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.3 13.4 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 13.2 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
1.3 13.0 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 11.6 PID_SHP2_PATHWAY SHP2 signaling
0.3 10.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 7.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 6.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.1 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.2 4.9 PID_MYC_PATHWAY C-MYC pathway
0.1 4.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 4.2 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 3.3 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 3.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3 2.7 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 2.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.7 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 79.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
1.0 14.7 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.2 8.8 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 6.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 5.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 5.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 4.6 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 4.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 4.5 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.1 4.4 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
1.4 4.1 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 2.8 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 2.6 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.8 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.7 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.4 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.4 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 0.9 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism