Motif ID: Stat4_Stat3_Stat5b

Z-value: 0.728

Transcription factors associated with Stat4_Stat3_Stat5b:

Gene SymbolEntrez IDGene Name
Stat3 ENSMUSG00000004040.10 Stat3
Stat4 ENSMUSG00000062939.5 Stat4
Stat5b ENSMUSG00000020919.5 Stat5b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat4mm10_v2_chr1_+_51987139_51987151-0.401.4e-02Click!
Stat3mm10_v2_chr11_-_100939457_1009394840.173.2e-01Click!
Stat5bmm10_v2_chr11_-_100850724_100850763-0.134.5e-01Click!


Activity profile for motif Stat4_Stat3_Stat5b.

activity profile for motif Stat4_Stat3_Stat5b


Sorted Z-values histogram for motif Stat4_Stat3_Stat5b

Sorted Z-values for motif Stat4_Stat3_Stat5b



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat4_Stat3_Stat5b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_80802789 4.766 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr4_-_64046925 2.502 ENSMUST00000107377.3
 Tnc
tenascin C
chr7_-_78577771 2.147 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr17_+_26715644 2.021 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr5_+_88886809 1.956 ENSMUST00000148750.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr10_-_95416850 1.938 ENSMUST00000020215.9
 Socs2
suppressor of cytokine signaling 2
chr10_-_95417099 1.898 ENSMUST00000135822.1
 Socs2
suppressor of cytokine signaling 2
chr13_-_67755132 1.703 ENSMUST00000091520.6
 Zfp85-rs1
zinc finger protein 85, related sequence 1
chr4_-_108031938 1.696 ENSMUST00000106708.1
 Podn
podocan
chr7_+_141476374 1.692 ENSMUST00000117634.1
 Tspan4
tetraspanin 4
chr13_-_67755192 1.586 ENSMUST00000144183.1
 Zfp85-rs1
zinc finger protein 85, related sequence 1
chr4_-_108032069 1.564 ENSMUST00000106709.2
 Podn
podocan
chr12_+_11265867 1.536 ENSMUST00000020931.5
 Smc6
structural maintenance of chromosomes 6
chr8_-_105568298 1.531 ENSMUST00000005849.5
 Agrp
agouti related protein
chr4_+_148602527 1.528 ENSMUST00000105701.2
ENSMUST00000052060.6
 Masp2

mannan-binding lectin serine peptidase 2

chr5_-_34513892 1.504 ENSMUST00000114359.1
ENSMUST00000030991.7
ENSMUST00000087737.3
 Tnip2


TNFAIP3 interacting protein 2


chr10_+_128909866 1.452 ENSMUST00000026407.7
 Cd63
CD63 antigen
chr3_-_107760221 1.422 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr16_-_23988852 1.405 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr8_+_25532125 1.362 ENSMUST00000167764.1
 Fgfr1
fibroblast growth factor receptor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 199 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.0 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 3.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.6 2.5 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.2 2.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.8 2.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.4 2.2 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.0 2.2 GO:0017145 stem cell division(GO:0017145)
0.7 2.1 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.4 2.0 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.3 2.0 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 2.0 GO:0015701 bicarbonate transport(GO:0015701)
0.0 2.0 GO:0060612 adipose tissue development(GO:0060612)
0.1 1.8 GO:0035455 response to interferon-alpha(GO:0035455)
0.2 1.5 GO:0008343 adult feeding behavior(GO:0008343)
0.2 1.5 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 1.5 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 1.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.5 1.4 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.5 1.4 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.5 1.4 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 GO:0032279 asymmetric synapse(GO:0032279)
0.0 3.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 3.0 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 2.3 GO:0030673 axolemma(GO:0030673)
0.6 2.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.3 2.1 GO:0005796 Golgi lumen(GO:0005796)
0.1 2.1 GO:0043194 axon initial segment(GO:0043194)
0.0 2.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.6 GO:0072562 blood microparticle(GO:0072562)
0.5 1.5 GO:0035061 interchromatin granule(GO:0035061)
0.0 1.5 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 1.5 GO:0001650 fibrillar center(GO:0001650)
0.5 1.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 1.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.3 GO:0051233 spindle midzone(GO:0051233)
0.1 1.2 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 1.0 GO:0044754 autolysosome(GO:0044754)
0.0 1.0 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.8 4.2 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 2.6 GO:0005518 collagen binding(GO:0005518)
0.4 2.5 GO:0045545 syndecan binding(GO:0045545)
0.1 2.4 GO:0017091 AU-rich element binding(GO:0017091)
0.3 2.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.4 2.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.4 2.1 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 2.1 GO:0003823 antigen binding(GO:0003823)
0.1 2.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.7 GO:0002039 p53 binding(GO:0002039)
0.1 1.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.4 GO:0001846 opsonin binding(GO:0001846)
0.3 1.2 GO:0019962 interferon receptor activity(GO:0004904) type I interferon receptor activity(GO:0004905) type I interferon binding(GO:0019962)
0.1 1.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.2 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 1.0 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 1.0 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.7 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 3.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 2.8 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 2.6 PID_SHP2_PATHWAY SHP2 signaling
0.0 2.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 1.7 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 1.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.2 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.0 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.0 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.8 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.5 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 2.4 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.2 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 2.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.1 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 2.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 2.0 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 1.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 1.6 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.5 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.5 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.1 1.4 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 1.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.2 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.0 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 1.0 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.9 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions