Motif ID: Tal1
Z-value: 0.696
Transcription factors associated with Tal1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tal1 | ENSMUSG00000028717.6 | Tal1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tal1 | mm10_v2_chr4_+_115057410_115057438 | -0.18 | 3.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 14.4 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.7 | 2.7 | GO:0090238 | positive regulation of arachidonic acid secretion(GO:0090238) |
| 0.4 | 1.2 | GO:0050975 | sensory perception of touch(GO:0050975) |
| 0.4 | 1.5 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 0.4 | 1.1 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.3 | 0.9 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 0.3 | 1.2 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.2 | 0.7 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 0.2 | 0.9 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.2 | 0.7 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.2 | 1.0 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.2 | 1.5 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.2 | 0.5 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) |
| 0.2 | 1.0 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.1 | 0.9 | GO:1990416 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.1 | 0.8 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.1 | 1.3 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.1 | 1.7 | GO:0002693 | positive regulation of cellular extravasation(GO:0002693) |
| 0.1 | 0.7 | GO:0000189 | MAPK import into nucleus(GO:0000189) |
| 0.1 | 0.8 | GO:0051461 | protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.1 | 0.3 | GO:0045113 | regulation of integrin biosynthetic process(GO:0045113) |
| 0.1 | 0.6 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.1 | 1.6 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.1 | 0.3 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 0.1 | 0.3 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
| 0.1 | 0.5 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.1 | 1.5 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 0.4 | GO:0046501 | protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.1 | 0.6 | GO:0042167 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.1 | 0.2 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) |
| 0.1 | 1.1 | GO:0007202 | activation of phospholipase C activity(GO:0007202) positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.1 | 0.8 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.1 | 0.4 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.1 | 0.5 | GO:0034242 | negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) |
| 0.0 | 0.2 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.0 | 1.2 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.0 | 0.3 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.0 | 0.1 | GO:0006059 | hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401) |
| 0.0 | 0.4 | GO:0061032 | visceral serous pericardium development(GO:0061032) |
| 0.0 | 0.1 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.0 | 0.4 | GO:0086023 | adrenergic receptor signaling pathway involved in heart process(GO:0086023) |
| 0.0 | 0.2 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.0 | 0.4 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804) |
| 0.0 | 0.2 | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360) |
| 0.0 | 0.3 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.0 | 0.7 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.1 | GO:2000484 | positive regulation of interleukin-8 secretion(GO:2000484) |
| 0.0 | 0.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.2 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.0 | 0.2 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.0 | 0.5 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.0 | 0.2 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.0 | 0.6 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 0.7 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.0 | 0.2 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 0.0 | 0.2 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.0 | 0.3 | GO:0042098 | T cell proliferation(GO:0042098) |
| 0.0 | 0.1 | GO:0001980 | regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980) |
| 0.0 | 0.2 | GO:0002098 | tRNA wobble uridine modification(GO:0002098) |
| 0.0 | 0.8 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.0 | 0.2 | GO:0034377 | plasma lipoprotein particle assembly(GO:0034377) |
| 0.0 | 0.6 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 0.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.2 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.1 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 14.4 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.7 | 2.7 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.3 | 1.4 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.2 | 0.7 | GO:1990075 | kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075) |
| 0.2 | 0.8 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.1 | 0.5 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.1 | 1.5 | GO:0038037 | G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648) |
| 0.1 | 0.6 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.1 | 1.3 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.1 | 1.4 | GO:0071437 | invadopodium(GO:0071437) |
| 0.1 | 0.8 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.1 | 0.9 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 0.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 0.8 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 1.2 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.1 | 0.9 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 0.1 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.0 | 0.3 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.0 | 0.2 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.0 | 3.6 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.4 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.0 | 0.2 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 0.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.2 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 0.1 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.0 | 0.5 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.0 | 0.2 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 0.1 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.7 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.2 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 0.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.2 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.1 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 14.4 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.4 | 1.5 | GO:0001639 | PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530) |
| 0.3 | 1.0 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.3 | 0.9 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.3 | 0.8 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.2 | 1.5 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.2 | 0.8 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.2 | 0.6 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 0.1 | 0.4 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.1 | 2.7 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.1 | 0.7 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.1 | 0.5 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.1 | 0.3 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
| 0.1 | 0.5 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
| 0.1 | 0.6 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.1 | 1.5 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 1.2 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.1 | 1.1 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 0.6 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.1 | 0.4 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.1 | 0.2 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
| 0.1 | 0.3 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.1 | 0.6 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.1 | 0.3 | GO:0008865 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.0 | 0.1 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
| 0.0 | 0.3 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 0.8 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.0 | 1.3 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.5 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.2 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.0 | 0.7 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 1.4 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin binding(GO:0030332) |
| 0.0 | 0.1 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.0 | 0.1 | GO:0071723 | lipopeptide binding(GO:0071723) |
| 0.0 | 0.1 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.0 | 1.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.1 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.2 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.0 | 0.1 | GO:0016803 | ether hydrolase activity(GO:0016803) |
| 0.0 | 0.3 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.0 | 0.1 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.0 | 1.0 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 0.7 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.0 | 0.5 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.3 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.0 | 0.1 | GO:0070051 | fibrinogen binding(GO:0070051) |
| 0.0 | 0.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.2 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.2 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.0 | 0.4 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.9 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 1.0 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.9 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.4 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.9 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.9 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.6 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 1.6 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 1.5 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 0.8 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 1.5 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 1.5 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 0.2 | REACTOME_PD1_SIGNALING | Genes involved in PD-1 signaling |
| 0.1 | 1.9 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.0 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.7 | REACTOME_RAF_MAP_KINASE_CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.0 | 1.7 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.0 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.9 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.6 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 1.8 | REACTOME_REGULATION_OF_APOPTOSIS | Genes involved in Regulation of Apoptosis |
| 0.0 | 2.1 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.7 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.7 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.2 | REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 0.3 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.0 | 0.2 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.2 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.8 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
