Motif ID: Tbp

Z-value: 1.961


Transcription factors associated with Tbp:

Gene SymbolEntrez IDGene Name
Tbp ENSMUSG00000014767.10 Tbp

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbpmm10_v2_chr17_+_15499888_15499960-0.446.1e-03Click!


Activity profile for motif Tbp.

activity profile for motif Tbp


Sorted Z-values histogram for motif Tbp

Sorted Z-values for motif Tbp



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbp

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 14.037 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr1_-_171196229 10.656 ENSMUST00000111332.1
 Pcp4l1
Purkinje cell protein 4-like 1
chr7_-_103853199 9.595 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr8_-_110168204 7.741 ENSMUST00000003754.6
 Calb2
calbindin 2
chr1_-_138842429 7.641 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr13_+_21717626 6.842 ENSMUST00000091754.2
 Hist1h3h
histone cluster 1, H3h
chr1_+_109993982 5.957 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr14_+_68083853 5.826 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr13_+_113035111 5.786 ENSMUST00000180543.1
ENSMUST00000181568.1
ENSMUST00000109244.2
ENSMUST00000181117.1
ENSMUST00000181741.1
 Cdc20b




cell division cycle 20B




chr6_-_136875794 5.697 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr13_+_23581563 5.455 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr7_-_142899985 5.206 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr13_-_23622502 5.143 ENSMUST00000062045.2
 Hist1h1e
histone cluster 1, H1e
chr2_-_164857542 5.142 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
 Pltp



phospholipid transfer protein



chr13_-_21780616 4.799 ENSMUST00000080511.2
 Hist1h1b
histone cluster 1, H1b
chr16_+_91225550 4.789 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr11_-_99024179 4.377 ENSMUST00000068031.7
 Top2a
topoisomerase (DNA) II alpha
chr8_+_94179089 4.294 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr2_-_93957040 4.220 ENSMUST00000148314.2
 Gm13889
predicted gene 13889
chr8_+_58912257 4.201 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 30.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 16.3 GO:0006334 nucleosome assembly(GO:0006334)
1.1 14.0 GO:0042573 retinoic acid metabolic process(GO:0042573)
2.7 13.4 GO:0015671 oxygen transport(GO:0015671)
0.5 9.0 GO:0019430 removal of superoxide radicals(GO:0019430)
1.5 7.6 GO:0035262 gonad morphogenesis(GO:0035262)
0.6 7.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.4 6.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
1.9 5.8 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.8 5.8 GO:0016584 nucleosome positioning(GO:0016584)
1.3 5.2 GO:0042414 epinephrine metabolic process(GO:0042414)
0.0 5.2 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
1.3 5.1 GO:0042360 vitamin E metabolic process(GO:0042360)
0.8 5.0 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
1.6 4.8 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
1.1 4.4 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.9 4.3 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.2 4.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.6 4.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.4 4.1 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 35.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 16.5 GO:0000786 nucleosome(GO:0000786)
0.0 14.0 GO:0005615 extracellular space(GO:0005615)
0.4 10.3 GO:0005921 gap junction(GO:0005921)
0.1 10.2 GO:0005814 centriole(GO:0005814)
1.0 8.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 7.6 GO:0043209 myelin sheath(GO:0043209)
0.1 7.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 6.6 GO:0005871 kinesin complex(GO:0005871)
1.9 5.8 GO:0033596 TSC1-TSC2 complex(GO:0033596)
1.7 5.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 5.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 5.1 GO:0005667 transcription factor complex(GO:0005667)
0.8 5.0 GO:0097512 cardiac myofibril(GO:0097512)
0.2 4.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 3.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 3.5 GO:0044754 autolysosome(GO:0044754)
0.8 3.4 GO:0045098 type III intermediate filament(GO:0045098)
0.1 3.2 GO:0005882 intermediate filament(GO:0005882)
0.8 3.1 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 31.4 GO:0003677 DNA binding(GO:0003677)
0.5 25.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 14.2 GO:0042393 histone binding(GO:0042393)
2.3 14.0 GO:0019841 retinol binding(GO:0019841)
2.7 13.4 GO:0005344 oxygen transporter activity(GO:0005344)
1.1 9.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.8 8.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 7.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 7.4 GO:0071837 HMG box domain binding(GO:0071837)
0.3 7.3 GO:0043274 phospholipase binding(GO:0043274)
0.2 6.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 6.6 GO:0003777 microtubule motor activity(GO:0003777)
1.0 5.2 GO:0035240 dopamine binding(GO:0035240)
0.2 5.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
1.1 4.4 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 4.4 GO:0005507 copper ion binding(GO:0005507)
0.1 4.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 4.1 GO:0008017 microtubule binding(GO:0008017)
0.8 3.2 GO:0004111 creatine kinase activity(GO:0004111)
0.1 3.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 10.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 8.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 8.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 5.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 5.0 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.2 4.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 4.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 4.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.5 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 2.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 1.4 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 1.3 PID_ATM_PATHWAY ATM pathway
0.0 1.3 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 1.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 1.1 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.0 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 46.2 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.9 14.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 8.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 7.3 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 6.6 REACTOME_KINESINS Genes involved in Kinesins
0.2 6.6 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 6.6 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.2 6.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.5 5.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.4 5.1 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 4.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 4.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 3.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 3.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.5 2.5 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.3 2.4 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.1 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 2.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis