Motif ID: Tbr1

Z-value: 1.000


Transcription factors associated with Tbr1:

Gene SymbolEntrez IDGene Name
Tbr1 ENSMUSG00000035033.9 Tbr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbr1mm10_v2_chr2_+_61804453_61804538-0.325.4e-02Click!


Activity profile for motif Tbr1.

activity profile for motif Tbr1


Sorted Z-values histogram for motif Tbr1

Sorted Z-values for motif Tbr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_111733924 4.296 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr7_-_46672537 3.541 ENSMUST00000049298.7
 Tph1
tryptophan hydroxylase 1
chr2_+_71528657 3.010 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr1_-_186705980 2.993 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr11_-_32222233 2.956 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr10_+_57784859 2.802 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr11_-_69900949 2.629 ENSMUST00000102580.3
 2810408A11Rik
RIKEN cDNA 2810408A11 gene
chr19_-_57008187 2.419 ENSMUST00000118800.1
ENSMUST00000111584.2
ENSMUST00000122359.1
ENSMUST00000148049.1
 Afap1l2



actin filament associated protein 1-like 2



chr4_-_109665249 2.370 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr11_-_69900930 2.264 ENSMUST00000018714.6
ENSMUST00000128046.1
 2810408A11Rik

RIKEN cDNA 2810408A11 gene

chr12_+_85473883 2.187 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr9_+_22454290 2.131 ENSMUST00000168332.1
 Gm17545
predicted gene, 17545
chr18_+_5591860 2.048 ENSMUST00000025081.5
ENSMUST00000159390.1
 Zeb1

zinc finger E-box binding homeobox 1

chr7_-_19698206 2.035 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr15_+_79891631 2.019 ENSMUST00000177350.1
ENSMUST00000177483.1
 Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chr2_+_71529085 1.945 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chr5_+_64812336 1.920 ENSMUST00000166409.1
 Klf3
Kruppel-like factor 3 (basic)
chr1_-_189688074 1.887 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr1_-_138847579 1.854 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr16_-_37384915 1.830 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 293 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 6.4 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.1 4.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.4 4.3 GO:0030421 defecation(GO:0030421)
0.3 4.2 GO:0060134 prepulse inhibition(GO:0060134)
0.7 4.0 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.4 3.5 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 3.5 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 3.4 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 3.2 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.6 3.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 3.1 GO:0035411 catenin import into nucleus(GO:0035411)
1.0 3.0 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.1 3.0 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 2.6 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.1 2.2 GO:0035994 response to muscle stretch(GO:0035994)
0.1 2.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.7 2.0 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.7 2.0 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.2 2.0 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 2.0 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 6.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.8 GO:0005604 basement membrane(GO:0005604)
0.0 3.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.7 3.4 GO:0097441 basilar dendrite(GO:0097441)
0.3 3.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 3.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.7 GO:0005770 late endosome(GO:0005770)
0.0 2.3 GO:0045171 intercellular bridge(GO:0045171)
0.4 2.2 GO:0035976 AP1 complex(GO:0035976)
0.7 2.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 1.9 GO:0070652 HAUS complex(GO:0070652)
0.0 1.9 GO:0005814 centriole(GO:0005814)
0.1 1.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 1.6 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 1.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.6 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 1.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 1.4 GO:0002080 acrosomal membrane(GO:0002080)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 4.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 4.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 4.1 GO:0019905 syntaxin binding(GO:0019905)
0.0 4.1 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
1.0 4.0 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 3.7 GO:0008083 growth factor activity(GO:0008083)
1.2 3.5 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 3.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 3.1 GO:0005504 fatty acid binding(GO:0005504)
0.7 3.0 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 3.0 GO:0008430 selenium binding(GO:0008430)
0.2 2.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 2.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 2.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 2.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.3 2.3 GO:1990239 steroid hormone binding(GO:1990239)
0.2 2.2 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.7 2.0 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 1.9 GO:0004089 carbonate dehydratase activity(GO:0004089)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.3 3.0 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 3.0 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 2.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 1.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 1.4 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 1.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.2 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.3 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.1 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.0 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.9 PID_FANCONI_PATHWAY Fanconi anemia pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 2.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.2 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 2.0 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 2.0 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 2.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.9 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.8 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 1.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 1.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.2 REACTOME_DNA_REPAIR Genes involved in DNA Repair
0.1 1.1 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 0.9 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 0.9 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 0.8 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere