Motif ID: Tbx15

Z-value: 0.708


Transcription factors associated with Tbx15:

Gene SymbolEntrez IDGene Name
Tbx15 ENSMUSG00000027868.5 Tbx15



Activity profile for motif Tbx15.

activity profile for motif Tbx15


Sorted Z-values histogram for motif Tbx15

Sorted Z-values for motif Tbx15



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx15

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_125490688 7.721 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr4_+_48045144 5.121 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr6_+_108213086 4.215 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr5_+_32136458 3.490 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr16_-_23988852 3.485 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr3_-_82074639 3.385 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr10_+_123264076 2.980 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr19_-_10304867 2.587 ENSMUST00000039327.4
 Dagla
diacylglycerol lipase, alpha
chr7_+_79810727 2.468 ENSMUST00000107394.1
 Mesp2
mesoderm posterior 2
chr4_-_129121889 2.449 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr17_-_81649607 2.395 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr17_-_29237759 2.077 ENSMUST00000137727.1
ENSMUST00000024805.7
 Cpne5

copine V

chr8_+_23035116 2.011 ENSMUST00000117296.1
ENSMUST00000141784.2
 Ank1

ankyrin 1, erythroid

chr15_-_71727815 1.984 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr16_-_43979050 1.916 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr11_+_98348404 1.894 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr6_-_28831747 1.860 ENSMUST00000062304.5
 Lrrc4
leucine rich repeat containing 4
chr13_-_43304153 1.816 ENSMUST00000055341.5
 Gfod1
glucose-fructose oxidoreductase domain containing 1
chr18_-_74961252 1.794 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr7_-_78577771 1.774 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 8.6 GO:0032763 regulation of mast cell cytokine production(GO:0032763)
0.7 7.7 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.7 4.2 GO:0042045 epithelial fluid transport(GO:0042045)
0.2 3.5 GO:0003334 keratinocyte development(GO:0003334)
1.1 3.4 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 3.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.1 3.2 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
1.0 3.1 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
1.0 3.0 GO:0001928 regulation of exocyst assembly(GO:0001928)
1.0 3.0 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.4 2.7 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
1.3 2.6 GO:0098917 retrograde trans-synaptic signaling(GO:0098917)
0.8 2.5 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.6 2.5 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.6 2.5 GO:0008078 mesodermal cell migration(GO:0008078)
0.8 2.4 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.2 2.4 GO:0015809 arginine transport(GO:0015809)
0.1 2.2 GO:0001919 regulation of receptor recycling(GO:0001919)
0.3 2.1 GO:0098909 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.1 2.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 5.5 GO:0045211 postsynaptic membrane(GO:0045211)
1.4 4.2 GO:0031088 platelet dense granule membrane(GO:0031088)
0.3 4.1 GO:0043196 varicosity(GO:0043196)
0.0 3.7 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.5 GO:0014704 intercalated disc(GO:0014704)
0.0 2.4 GO:0001650 fibrillar center(GO:0001650)
0.1 2.2 GO:0043083 synaptic cleft(GO:0043083)
0.1 2.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 2.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 2.0 GO:0043235 receptor complex(GO:0043235)
0.3 1.9 GO:0071203 WASH complex(GO:0071203)
0.4 1.8 GO:0001533 cornified envelope(GO:0001533)
0.0 1.8 GO:0005769 early endosome(GO:0005769)
0.3 1.6 GO:0030314 junctional membrane complex(GO:0030314)
0.0 1.6 GO:0005657 replication fork(GO:0005657)
0.0 1.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.7 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.2 6.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 4.3 GO:0030275 LRR domain binding(GO:0030275)
1.4 4.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.3 3.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.3 3.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 3.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.6 3.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.4 3.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.0 3.0 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.3 2.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.3 2.4 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.5 2.2 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 2.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.3 2.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 2.0 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 2.0 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.6 1.9 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.1 1.9 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.3 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 3.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.0 PID_FGF_PATHWAY FGF signaling pathway
0.1 3.0 PID_SHP2_PATHWAY SHP2 signaling
0.1 2.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.2 2.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 2.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 2.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.8 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.5 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.3 PID_INSULIN_PATHWAY Insulin Pathway
0.0 1.2 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.2 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.2 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.0 PID_CERAMIDE_PATHWAY Ceramide signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.4 7.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 5.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.4 4.1 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 3.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.6 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 2.4 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 2.1 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 2.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.6 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.4 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 1.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 1.1 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.2 1.0 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport