Motif ID: Tbx1_Eomes

Z-value: 0.943

Transcription factors associated with Tbx1_Eomes:

Gene SymbolEntrez IDGene Name
Eomes ENSMUSG00000032446.8 Eomes
Tbx1 ENSMUSG00000009097.9 Tbx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Eomesmm10_v2_chr9_+_118478344_1184784510.581.8e-04Click!


Activity profile for motif Tbx1_Eomes.

activity profile for motif Tbx1_Eomes


Sorted Z-values histogram for motif Tbx1_Eomes

Sorted Z-values for motif Tbx1_Eomes



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx1_Eomes

PNG image of the network

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Top targets:


Showing 1 to 20 of 154 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 19.326 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_+_6730051 14.145 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr1_-_138847579 11.575 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr2_-_13011747 10.278 ENSMUST00000061545.5
 C1ql3
C1q-like 3
chr1_+_6730135 8.695 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr6_+_15196949 8.449 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr7_-_28302238 7.758 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr1_+_132316112 5.737 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr11_-_84068357 5.500 ENSMUST00000100705.4
 Dusp14
dual specificity phosphatase 14
chr17_+_29093763 5.360 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr11_-_84068766 5.023 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr1_+_153665274 4.911 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr2_-_57114970 4.775 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr4_+_125490688 4.164 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr1_+_153665666 3.990 ENSMUST00000111814.1
ENSMUST00000111810.1
 Rgs8

regulator of G-protein signaling 8

chr18_-_46212595 3.860 ENSMUST00000037011.4
 Trim36
tripartite motif-containing 36
chr9_-_43239816 3.843 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr1_+_153665587 3.440 ENSMUST00000147700.1
 Rgs8
regulator of G-protein signaling 8
chr7_-_141443989 3.345 ENSMUST00000026580.5
 Lrdd
leucine-rich and death domain containing
chr1_+_153665627 3.184 ENSMUST00000147482.1
 Rgs8
regulator of G-protein signaling 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 22.8 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.1 15.5 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 12.5 GO:0050807 regulation of synapse organization(GO:0050807)
2.3 11.6 GO:0035262 gonad morphogenesis(GO:0035262)
0.3 9.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.7 8.4 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.6 7.8 GO:0007386 compartment pattern specification(GO:0007386)
0.1 5.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.6 5.4 GO:0071493 cellular response to UV-B(GO:0071493)
1.2 4.8 GO:0051866 general adaptation syndrome(GO:0051866)
0.4 4.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 3.9 GO:0007340 acrosome reaction(GO:0007340)
0.0 3.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
1.0 3.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 3.1 GO:0035411 catenin import into nucleus(GO:0035411)
1.4 2.8 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.3 2.6 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 2.4 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.8 2.3 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 2.2 GO:0010587 miRNA catabolic process(GO:0010587)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.9 GO:0032993 protein-DNA complex(GO:0032993)
0.4 15.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 10.4 GO:0005581 collagen trimer(GO:0005581)
1.8 5.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 5.3 GO:0016607 nuclear speck(GO:0016607)
0.1 4.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 3.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 2.6 GO:0001741 XY body(GO:0001741)
0.3 2.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 2.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.3 1.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 1.4 GO:0031983 vesicle lumen(GO:0031983)
0.4 1.2 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.0 1.2 GO:0035097 histone methyltransferase complex(GO:0035097)
0.2 0.9 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.7 GO:1990357 terminal web(GO:1990357)
0.0 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.4 GO:0001047 core promoter binding(GO:0001047)
0.4 15.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.6 9.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 7.8 GO:0005112 Notch binding(GO:0005112)
1.8 5.4 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 5.4 GO:0000287 magnesium ion binding(GO:0000287)
0.8 4.2 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.0 3.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 2.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 2.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.5 2.4 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.4 2.3 GO:0070728 leucine binding(GO:0070728)
0.2 2.2 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 1.9 GO:0017048 Rho GTPase binding(GO:0017048)
0.2 1.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 1.7 GO:0070410 co-SMAD binding(GO:0070410)
0.3 1.6 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.2 1.5 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 1.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 8.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.6 5.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 2.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 2.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.9 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 1.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.4 PID_LKB1_PATHWAY LKB1 signaling events
0.1 1.2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.0 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.9 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.7 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.7 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.5 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 5.4 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 4.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 3.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 3.1 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.2 2.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 2.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.7 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.4 1.6 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 1.6 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 1.2 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.1 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 0.9 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1