Motif ID: Tbx2

Z-value: 0.726


Transcription factors associated with Tbx2:

Gene SymbolEntrez IDGene Name
Tbx2 ENSMUSG00000000093.6 Tbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx2mm10_v2_chr11_+_85832551_85832551-0.251.3e-01Click!


Activity profile for motif Tbx2.

activity profile for motif Tbx2


Sorted Z-values histogram for motif Tbx2

Sorted Z-values for motif Tbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_138847579 8.169 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9

LIM homeobox protein 9

chr10_+_26229707 7.563 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr11_-_84068766 4.679 ENSMUST00000018792.5
Dusp14
dual specificity phosphatase 14
chr11_-_84068357 4.434 ENSMUST00000100705.4
Dusp14
dual specificity phosphatase 14
chr7_-_28302238 3.500 ENSMUST00000108315.3
Dll3
delta-like 3 (Drosophila)
chr7_-_115824699 3.311 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr1_+_132316112 3.200 ENSMUST00000082125.5
ENSMUST00000072177.7
Nuak2

NUAK family, SNF1-like kinase, 2

chr1_-_52500679 2.955 ENSMUST00000069792.7
Nab1
Ngfi-A binding protein 1
chr2_+_124089961 2.944 ENSMUST00000103241.1
Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr5_-_5514730 2.930 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
Cldn12



claudin 12



chr7_-_137314394 2.741 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr11_-_101551837 2.725 ENSMUST00000017290.4
Brca1
breast cancer 1
chr6_+_15196949 2.640 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
Foxp2



forkhead box P2



chr7_-_132813799 2.533 ENSMUST00000097998.2
Fam53b
family with sequence similarity 53, member B
chr5_-_5514873 2.463 ENSMUST00000060947.7
Cldn12
claudin 12
chr2_+_152081529 2.403 ENSMUST00000064061.3
Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chrX_-_53269020 2.105 ENSMUST00000114838.1
Fam122b
family with sequence similarity 122, member B
chr10_-_120899067 1.832 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chr2_+_52857844 1.794 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
Fmnl2


formin-like 2


chr4_+_94614483 1.732 ENSMUST00000030311.4
ENSMUST00000107104.2
Ift74

intraflagellar transport 74

chr4_+_11191726 1.692 ENSMUST00000029866.9
ENSMUST00000108324.3
Ccne2

cyclin E2

chr9_-_43239816 1.686 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr4_+_116221689 1.675 ENSMUST00000106490.2
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr1_-_172329261 1.655 ENSMUST00000062387.2
Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr9_+_48495345 1.644 ENSMUST00000048824.7
Gm5617
predicted gene 5617
chr4_+_116221633 1.637 ENSMUST00000030464.7
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr1_+_63273261 1.488 ENSMUST00000114132.1
ENSMUST00000126932.1
Zdbf2

zinc finger, DBF-type containing 2

chr7_-_141443989 1.438 ENSMUST00000026580.5
Lrdd
leucine-rich and death domain containing
chrX_+_139210031 1.424 ENSMUST00000113043.1
ENSMUST00000169886.1
ENSMUST00000113045.2
Mum1l1


melanoma associated antigen (mutated) 1-like 1


chr3_+_102734496 1.402 ENSMUST00000029451.5
Tspan2
tetraspanin 2
chr4_-_141874879 1.388 ENSMUST00000036854.3
Efhd2
EF hand domain containing 2
chr4_+_116221590 1.380 ENSMUST00000147292.1
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr4_-_132510493 1.364 ENSMUST00000030724.8
Sesn2
sestrin 2
chr2_+_68861564 1.232 ENSMUST00000176018.1
Cers6
ceramide synthase 6
chr6_+_116264186 1.165 ENSMUST00000036503.7
ENSMUST00000112900.3
Zfand4

zinc finger, AN1-type domain 4

chr2_-_114052804 1.146 ENSMUST00000090269.6
Actc1
actin, alpha, cardiac muscle 1
chr1_-_51915968 1.126 ENSMUST00000046390.7
Myo1b
myosin IB
chr6_+_115134899 1.125 ENSMUST00000009538.5
ENSMUST00000169345.1
Syn2

synapsin II

chr5_+_108065742 1.094 ENSMUST00000081567.4
ENSMUST00000170319.1
ENSMUST00000112626.1
Mtf2


metal response element binding transcription factor 2


chr18_+_84088077 1.083 ENSMUST00000060223.2
Zadh2
zinc binding alcohol dehydrogenase, domain containing 2
chr2_+_68861433 1.042 ENSMUST00000028426.2
Cers6
ceramide synthase 6
chr6_-_94700137 1.031 ENSMUST00000101126.2
ENSMUST00000032105.4
Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr1_-_105356658 1.000 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152

ring finger protein 152

chr1_+_170214826 0.972 ENSMUST00000159201.1
ENSMUST00000055830.1
4930500M09Rik

RIKEN cDNA 4930500M09 gene

chr5_+_108065696 0.959 ENSMUST00000172045.1
Mtf2
metal response element binding transcription factor 2
chr18_-_62741387 0.864 ENSMUST00000097557.3
Spink13
serine peptidase inhibitor, Kazal type 13
chr9_-_48495321 0.834 ENSMUST00000170000.2
Rbm7
RNA binding motif protein 7
chr6_+_50110837 0.806 ENSMUST00000167628.1
Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr9_+_53850243 0.725 ENSMUST00000048485.5
Sln
sarcolipin
chr12_-_41485751 0.709 ENSMUST00000043884.4
Lrrn3
leucine rich repeat protein 3, neuronal
chr5_+_111733924 0.697 ENSMUST00000180627.1
Gm26897
predicted gene, 26897
chr11_-_23895208 0.696 ENSMUST00000102863.2
ENSMUST00000020513.3
Papolg

poly(A) polymerase gamma

chr3_+_32436376 0.667 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr2_-_103797617 0.599 ENSMUST00000028607.6
Caprin1
cell cycle associated protein 1
chr3_+_96104498 0.564 ENSMUST00000132980.1
ENSMUST00000138206.1
ENSMUST00000090785.2
ENSMUST00000035519.5
Otud7b



OTU domain containing 7B



chr13_+_80886095 0.539 ENSMUST00000161441.1
Arrdc3
arrestin domain containing 3
chr15_+_61987034 0.537 ENSMUST00000159338.1
Myc
myelocytomatosis oncogene
chr4_-_41464816 0.522 ENSMUST00000108055.2
ENSMUST00000154535.1
ENSMUST00000030148.5
Kif24


kinesin family member 24


chr19_-_28963863 0.510 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr9_-_85749308 0.501 ENSMUST00000039213.8
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr7_+_27607997 0.482 ENSMUST00000142365.1
Akt2
thymoma viral proto-oncogene 2
chr8_+_106870827 0.470 ENSMUST00000176144.1
ENSMUST00000175987.1
Has3

hyaluronan synthase 3

chr1_-_172082757 0.465 ENSMUST00000003550.4
Ncstn
nicastrin
chr7_+_133637686 0.441 ENSMUST00000128901.2
2700050L05Rik
RIKEN cDNA 2700050L05 gene
chr2_+_54436317 0.421 ENSMUST00000112636.1
ENSMUST00000112635.1
ENSMUST00000112634.1
Galnt13


UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13


chr9_+_19641224 0.420 ENSMUST00000079042.6
Zfp317
zinc finger protein 317
chr9_-_31464238 0.415 ENSMUST00000048050.7
Tmem45b
transmembrane protein 45b
chrX_+_153006461 0.404 ENSMUST00000095755.3
Usp51
ubiquitin specific protease 51
chr9_-_95845215 0.389 ENSMUST00000093800.2
Pls1
plastin 1 (I-isoform)
chr4_-_58499398 0.386 ENSMUST00000107570.1
Lpar1
lysophosphatidic acid receptor 1
chr6_-_28261907 0.376 ENSMUST00000115320.1
ENSMUST00000123098.1
ENSMUST00000115321.2
ENSMUST00000155494.1
Zfp800



zinc finger protein 800



chr9_+_73044833 0.367 ENSMUST00000184146.1
ENSMUST00000034722.4
Rab27a

RAB27A, member RAS oncogene family

chr7_+_27607748 0.364 ENSMUST00000136962.1
Akt2
thymoma viral proto-oncogene 2
chr4_-_103214791 0.359 ENSMUST00000094947.2
ENSMUST00000036195.6
Slc35d1

solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1

chr5_-_108132541 0.315 ENSMUST00000119437.1
ENSMUST00000118036.1
Tmed5

transmembrane emp24 protein transport domain containing 5

chr9_-_22131801 0.308 ENSMUST00000069330.6
Acp5
acid phosphatase 5, tartrate resistant
chr5_+_120513102 0.306 ENSMUST00000111889.1
Slc8b1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr12_-_31634592 0.293 ENSMUST00000020979.7
ENSMUST00000177962.1
Bcap29

B cell receptor associated protein 29

chr13_+_13590402 0.270 ENSMUST00000110559.1
Lyst
lysosomal trafficking regulator
chr2_+_175469985 0.261 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
Gm8923



predicted gene 8923



chr5_+_96209463 0.244 ENSMUST00000117766.1
Mrpl1
mitochondrial ribosomal protein L1
chr14_+_31251454 0.214 ENSMUST00000022458.4
Bap1
Brca1 associated protein 1
chr1_+_164115264 0.193 ENSMUST00000162746.1
Selp
selectin, platelet
chr2_-_175703646 0.154 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
Gm4245


predicted gene 4245


chr11_-_87826023 0.153 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr3_-_84220853 0.131 ENSMUST00000154152.1
ENSMUST00000107693.2
ENSMUST00000107695.2
Trim2


tripartite motif-containing 2


chr2_+_175372436 0.122 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
Gm4723


predicted gene 4723


chr1_-_51941261 0.109 ENSMUST00000097103.3
Gm8420
predicted gene 8420
chrX_+_101429555 0.106 ENSMUST00000033673.6
Nono
non-POU-domain-containing, octamer binding protein
chr19_-_42202150 0.099 ENSMUST00000018966.7
Sfrp5
secreted frizzled-related sequence protein 5
chr7_-_104950441 0.090 ENSMUST00000179862.1
Gm5900
predicted pseudogene 5900
chr15_-_10470490 0.080 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr6_+_42286709 0.066 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr3_+_36552600 0.064 ENSMUST00000029269.5
ENSMUST00000136890.1
Exosc9

exosome component 9

chr4_+_84884276 0.056 ENSMUST00000047023.6
Cntln
centlein, centrosomal protein
chr14_-_55643251 0.054 ENSMUST00000120041.1
ENSMUST00000121937.1
ENSMUST00000133707.1
ENSMUST00000002391.8
ENSMUST00000121791.1
Tm9sf1




transmembrane 9 superfamily member 1




chr1_+_131970589 0.022 ENSMUST00000027695.6
Slc45a3
solute carrier family 45, member 3
chr6_+_42286676 0.021 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr11_+_58104229 0.020 ENSMUST00000108843.1
ENSMUST00000134896.1
Cnot8

CCR4-NOT transcription complex, subunit 8

chr14_-_89898466 0.019 ENSMUST00000081204.4
Gm10110
predicted gene 10110
chr11_-_69900949 0.015 ENSMUST00000102580.3
2810408A11Rik
RIKEN cDNA 2810408A11 gene
chr10_-_128211788 0.010 ENSMUST00000061995.8
Spryd4
SPRY domain containing 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 8.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.9 2.7 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.7 3.5 GO:0007386 compartment pattern specification(GO:0007386)
0.5 1.8 GO:0030091 protein repair(GO:0030091)
0.5 1.4 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.4 2.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.4 1.4 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.3 1.0 GO:0032474 otolith morphogenesis(GO:0032474)
0.3 3.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.3 9.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2 1.7 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.2 1.1 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.2 0.7 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.2 2.6 GO:0060013 righting reflex(GO:0060013) positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.2 0.7 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.2 0.5 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.2 0.9 GO:0060467 negative regulation of fertilization(GO:0060467)
0.2 0.5 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 0.8 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.1 0.5 GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.1 0.4 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.1 1.0 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.4 GO:0097278 complement-dependent cytotoxicity(GO:0097278)
0.1 0.6 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 4.0 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 0.3 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.4 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.3 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 2.9 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 2.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 3.0 GO:0014037 Schwann cell differentiation(GO:0014037)
0.1 1.8 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 1.7 GO:0010107 potassium ion import(GO:0010107)
0.1 2.6 GO:0035411 catenin import into nucleus(GO:0035411)
0.1 0.2 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 0.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 2.4 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 1.7 GO:0007129 synapsis(GO:0007129)
0.0 0.2 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.4 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.5 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.2 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 1.1 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.1 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.3 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.0 0.4 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 1.1 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.5 2.7 GO:0070531 BRCA1-A complex(GO:0070531)
0.2 5.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 1.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 2.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.4 GO:1990357 terminal web(GO:1990357)
0.1 0.4 GO:0033093 multivesicular body membrane(GO:0032585) Weibel-Palade body(GO:0033093)
0.1 5.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.5 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 1.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.2 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 1.1 GO:0031201 SNARE complex(GO:0031201)
0.0 0.3 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.7 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.1 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.6 9.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 1.1 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.3 1.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 1.8 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.3 2.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 1.4 GO:0070728 leucine binding(GO:0070728)
0.2 0.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 2.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.5 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.7 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 3.5 GO:0005112 Notch binding(GO:0005112)
0.1 0.7 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 0.3 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 1.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.6 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.4 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 1.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0042806 fucose binding(GO:0042806)
0.0 0.4 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 2.7 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.3 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 1.7 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 6.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.1 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.6 GO:0017022 myosin binding(GO:0017022)
0.0 0.5 GO:0031690 adrenergic receptor binding(GO:0031690)
0.0 0.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 3.2 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.5 GO:0070888 E-box binding(GO:0070888)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.4 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 1.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.7 PID_BARD1_PATHWAY BARD1 signaling events
0.0 4.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 2.5 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 1.0 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 2.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.4 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.2 5.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 2.7 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 2.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.1 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 1.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 0.8 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 2.3 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.7 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.5 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins