Motif ID: Tbx2

Z-value: 0.726


Transcription factors associated with Tbx2:

Gene SymbolEntrez IDGene Name
Tbx2 ENSMUSG00000000093.6 Tbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx2mm10_v2_chr11_+_85832551_85832551-0.251.3e-01Click!


Activity profile for motif Tbx2.

activity profile for motif Tbx2


Sorted Z-values histogram for motif Tbx2

Sorted Z-values for motif Tbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 102 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_138847579 8.169 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr10_+_26229707 7.563 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr11_-_84068766 4.679 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr11_-_84068357 4.434 ENSMUST00000100705.4
 Dusp14
dual specificity phosphatase 14
chr7_-_28302238 3.500 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr7_-_115824699 3.311 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr1_+_132316112 3.200 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr1_-_52500679 2.955 ENSMUST00000069792.7
 Nab1
Ngfi-A binding protein 1
chr2_+_124089961 2.944 ENSMUST00000103241.1
 Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr5_-_5514730 2.930 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
 Cldn12



claudin 12



chr7_-_137314394 2.741 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr11_-_101551837 2.725 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr6_+_15196949 2.640 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr7_-_132813799 2.533 ENSMUST00000097998.2
 Fam53b
family with sequence similarity 53, member B
chr5_-_5514873 2.463 ENSMUST00000060947.7
 Cldn12
claudin 12
chr2_+_152081529 2.403 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chrX_-_53269020 2.105 ENSMUST00000114838.1
 Fam122b
family with sequence similarity 122, member B
chr10_-_120899067 1.832 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr2_+_52857844 1.794 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
 Fmnl2


formin-like 2


chr4_+_94614483 1.732 ENSMUST00000030311.4
ENSMUST00000107104.2
 Ift74

intraflagellar transport 74


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.6 8.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 4.0 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.7 3.5 GO:0007386 compartment pattern specification(GO:0007386)
0.3 3.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 3.0 GO:0014037 Schwann cell differentiation(GO:0014037)
0.1 2.9 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 2.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.9 2.7 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.2 2.6 GO:0060013 righting reflex(GO:0060013) positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 2.6 GO:0035411 catenin import into nucleus(GO:0035411)
0.0 2.4 GO:2001222 regulation of neuron migration(GO:2001222)
0.4 2.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.5 1.8 GO:0030091 protein repair(GO:0030091)
0.1 1.8 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.2 1.7 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 1.7 GO:0010107 potassium ion import(GO:0010107)
0.0 1.7 GO:0007129 synapsis(GO:0007129)
0.5 1.4 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.4 1.4 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 5.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.5 2.7 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 2.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.6 1.7 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 1.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 1.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 1.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.1 GO:0031201 SNARE complex(GO:0031201)
0.0 1.1 GO:0072562 blood microparticle(GO:0072562)
0.1 0.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.7 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 0.5 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.4 GO:1990357 terminal web(GO:1990357)
0.1 0.4 GO:0033093 multivesicular body membrane(GO:0032585) Weibel-Palade body(GO:0033093)
0.0 0.3 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 9.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 6.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7 4.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 3.5 GO:0005112 Notch binding(GO:0005112)
0.0 3.2 GO:0000287 magnesium ion binding(GO:0000287)
0.1 2.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 2.7 GO:0003684 damaged DNA binding(GO:0003684)
0.3 2.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 2.1 GO:0035064 methylated histone binding(GO:0035064)
0.3 1.8 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 1.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.3 1.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 1.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.7 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 1.6 GO:0017022 myosin binding(GO:0017022)
0.2 1.4 GO:0070728 leucine binding(GO:0070728)
0.4 1.1 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 1.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 4.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 2.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.7 PID_BARD1_PATHWAY BARD1 signaling events
0.0 2.5 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.1 1.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.0 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.5 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.4 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.4 4.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 2.7 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 2.3 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 1.1 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 0.8 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.5 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.5 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins