Motif ID: Tbx21

Z-value: 0.894


Transcription factors associated with Tbx21:

Gene SymbolEntrez IDGene Name
Tbx21 ENSMUSG00000001444.2 Tbx21



Activity profile for motif Tbx21.

activity profile for motif Tbx21


Sorted Z-values histogram for motif Tbx21

Sorted Z-values for motif Tbx21



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx21

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_56969827 7.572 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr1_-_56969864 7.559 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr9_-_112185726 6.970 ENSMUST00000160240.1
ENSMUST00000162065.1
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr9_-_112185939 5.825 ENSMUST00000070218.5
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr18_+_67088287 5.485 ENSMUST00000025402.7
Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr10_-_13868932 3.973 ENSMUST00000019942.5
ENSMUST00000162610.1
Aig1

androgen-induced 1

chr10_-_13868779 3.683 ENSMUST00000105534.3
Aig1
androgen-induced 1
chr19_+_12460749 3.627 ENSMUST00000081035.7
Mpeg1
macrophage expressed gene 1
chr11_-_74590065 3.234 ENSMUST00000145524.1
ENSMUST00000047488.7
Rap1gap2

RAP1 GTPase activating protein 2

chr11_-_74590186 3.206 ENSMUST00000102521.1
Rap1gap2
RAP1 GTPase activating protein 2
chr18_+_37020097 3.107 ENSMUST00000047614.1
Pcdha2
protocadherin alpha 2
chr7_+_45785331 3.013 ENSMUST00000120005.1
ENSMUST00000123585.1
Lmtk3

lemur tyrosine kinase 3

chrX_-_152769461 2.802 ENSMUST00000101141.2
ENSMUST00000062317.4
Shroom2

shroom family member 2

chr7_-_4789541 2.649 ENSMUST00000168578.1
Tmem238
transmembrane protein 238
chr16_+_8470763 2.536 ENSMUST00000046470.9
ENSMUST00000150790.1
ENSMUST00000142899.1
Mettl22


methyltransferase like 22


chr7_-_126704816 2.500 ENSMUST00000032949.7
Coro1a
coronin, actin binding protein 1A
chr6_-_60829826 2.374 ENSMUST00000163779.1
Snca
synuclein, alpha
chr8_-_68735058 2.286 ENSMUST00000136060.1
ENSMUST00000130214.1
ENSMUST00000078350.6
Csgalnact1


chondroitin sulfate N-acetylgalactosaminyltransferase 1


chr1_+_34801704 2.241 ENSMUST00000047664.9
Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr10_-_75560330 2.147 ENSMUST00000051129.9
Fam211b
family with sequence similarity 211, member B
chr11_-_120643643 2.056 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
Pycr1




pyrroline-5-carboxylate reductase 1




chr9_-_106656081 1.936 ENSMUST00000023959.7
Grm2
glutamate receptor, metabotropic 2
chr11_+_70451905 1.924 ENSMUST00000151013.1
ENSMUST00000019067.7
Med11

mediator of RNA polymerase II transcription, subunit 11 homolog (S. cerevisiae)

chr19_+_34192229 1.921 ENSMUST00000054956.8
Stambpl1
STAM binding protein like 1
chr11_+_103171081 1.918 ENSMUST00000042286.5
Fmnl1
formin-like 1
chr3_-_89322883 1.852 ENSMUST00000029673.5
Efna3
ephrin A3
chr6_-_50261743 1.819 ENSMUST00000101405.3
ENSMUST00000165099.1
ENSMUST00000170142.1
Dfna5


deafness, autosomal dominant 5 (human)


chr3_-_127499095 1.769 ENSMUST00000182594.1
Ank2
ankyrin 2, brain
chr11_-_65162904 1.755 ENSMUST00000093002.5
ENSMUST00000047463.8
Arhgap44

Rho GTPase activating protein 44

chr16_+_75592844 1.720 ENSMUST00000114249.1
ENSMUST00000046378.7
ENSMUST00000114253.1
Rbm11


RNA binding motif protein 11


chr8_+_25849618 1.710 ENSMUST00000098858.3
Kcnu1
potassium channel, subfamily U, member 1
chr5_-_24730635 1.579 ENSMUST00000068693.5
Wdr86
WD repeat domain 86
chr11_+_24080664 1.562 ENSMUST00000118955.1
Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr6_+_83101565 1.549 ENSMUST00000101254.3
Ccdc142
coiled-coil domain containing 142
chr13_-_100108337 1.469 ENSMUST00000180822.1
BC001981
cDNA sequence BC001981
chr15_-_84105662 1.452 ENSMUST00000082365.5
Sult4a1
sulfotransferase family 4A, member 1
chr12_-_70227622 1.366 ENSMUST00000071250.6
Pygl
liver glycogen phosphorylase
chr17_-_27029009 1.352 ENSMUST00000078691.5
Bak1
BCL2-antagonist/killer 1
chrX_-_136868537 1.339 ENSMUST00000058814.6
Rab9b
RAB9B, member RAS oncogene family
chr13_+_56609516 1.335 ENSMUST00000045173.8
Tgfbi
transforming growth factor, beta induced
chr2_-_51934644 1.324 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr2_+_84678396 1.286 ENSMUST00000102645.3
Med19
mediator of RNA polymerase II transcription, subunit 19 homolog (yeast)
chrX_+_74297097 1.266 ENSMUST00000019231.5
ENSMUST00000147900.1
ENSMUST00000147275.1
ENSMUST00000114171.3
Atp6ap1



ATPase, H+ transporting, lysosomal accessory protein 1



chr6_-_50261943 1.225 ENSMUST00000167893.1
Dfna5
deafness, autosomal dominant 5 (human)
chr14_-_54517353 1.220 ENSMUST00000023873.5
Prmt5
protein arginine N-methyltransferase 5
chr16_-_4003750 1.207 ENSMUST00000171658.1
ENSMUST00000171762.1
Slx4

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

chr5_-_36582381 1.170 ENSMUST00000141043.1
ENSMUST00000031094.8
Tbc1d14

TBC1 domain family, member 14

chr1_-_97661668 1.153 ENSMUST00000153115.1
ENSMUST00000142234.1
D1Ertd622e

DNA segment, Chr 1, ERATO Doi 622, expressed

chr7_+_18884679 1.121 ENSMUST00000032573.6
Pglyrp1
peptidoglycan recognition protein 1
chr6_+_36388055 1.107 ENSMUST00000172278.1
Chrm2
cholinergic receptor, muscarinic 2, cardiac
chr6_-_38124568 1.096 ENSMUST00000040259.4
Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr2_+_28641227 1.094 ENSMUST00000028155.5
ENSMUST00000113869.1
ENSMUST00000113867.2
Tsc1


tuberous sclerosis 1


chr9_-_35558522 1.094 ENSMUST00000034612.5
Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr19_+_44989073 1.083 ENSMUST00000026225.8
Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr17_-_24527830 1.026 ENSMUST00000176353.1
ENSMUST00000176237.1
Traf7

TNF receptor-associated factor 7

chr1_+_59912972 1.026 ENSMUST00000036540.5
Fam117b
family with sequence similarity 117, member B
chr14_+_54426902 0.990 ENSMUST00000010550.7
Mrpl52
mitochondrial ribosomal protein L52
chr8_+_40423786 0.944 ENSMUST00000049389.4
ENSMUST00000128166.1
ENSMUST00000167766.1
Zdhhc2


zinc finger, DHHC domain containing 2


chr2_-_84678828 0.868 ENSMUST00000111665.1
Tmx2
thioredoxin-related transmembrane protein 2
chr17_-_24527925 0.861 ENSMUST00000176652.1
Traf7
TNF receptor-associated factor 7
chr1_+_60409612 0.857 ENSMUST00000052332.8
Abi2
abl-interactor 2
chr4_-_155669171 0.840 ENSMUST00000103176.3
Mib2
mindbomb homolog 2 (Drosophila)
chr19_-_5610038 0.830 ENSMUST00000113641.2
Kat5
K(lysine) acetyltransferase 5
chr12_-_70231414 0.821 ENSMUST00000161083.1
Pygl
liver glycogen phosphorylase
chr2_+_164823001 0.805 ENSMUST00000132282.1
Zswim1
zinc finger SWIM-type containing 1
chr4_+_155086577 0.791 ENSMUST00000030915.4
ENSMUST00000155775.1
ENSMUST00000127457.1
Morn1


MORN repeat containing 1


chr10_-_39899238 0.752 ENSMUST00000178563.1
AA474331
expressed sequence AA474331
chr18_+_37742088 0.720 ENSMUST00000003599.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr6_+_113378113 0.682 ENSMUST00000171058.1
ENSMUST00000156898.1
Arpc4

actin related protein 2/3 complex, subunit 4

chr14_+_64588112 0.648 ENSMUST00000181808.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr11_+_22971991 0.645 ENSMUST00000049506.5
Zrsr1
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
chr13_+_104178797 0.582 ENSMUST00000022225.5
ENSMUST00000069187.5
Trim23

tripartite motif-containing 23

chr1_-_179546261 0.581 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial
chr7_+_19149722 0.575 ENSMUST00000049294.2
Snrpd2
small nuclear ribonucleoprotein D2
chr6_-_142964404 0.569 ENSMUST00000032421.3
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr6_+_94500313 0.558 ENSMUST00000061118.8
Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chr3_-_54735001 0.558 ENSMUST00000153224.1
Exosc8
exosome component 8
chrX_-_95444789 0.550 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr7_-_126861648 0.547 ENSMUST00000129812.1
ENSMUST00000106342.1
Ino80e

INO80 complex subunit E

chr1_+_183388981 0.539 ENSMUST00000097043.5
Taf1a
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A
chr10_+_77978524 0.526 ENSMUST00000105397.3
ENSMUST00000105398.1
1810043G02Rik

RIKEN cDNA 1810043G02 gene

chr6_-_113377866 0.486 ENSMUST00000032410.7
Tada3
transcriptional adaptor 3
chr7_-_27178835 0.471 ENSMUST00000093040.6
Rab4b
RAB4B, member RAS oncogene family
chr11_+_88047302 0.470 ENSMUST00000139129.2
Srsf1
serine/arginine-rich splicing factor 1
chr8_-_13974715 0.468 ENSMUST00000119182.1
ENSMUST00000062613.4
Tdrp

testis development related protein

chr7_-_126861828 0.447 ENSMUST00000106343.1
Ino80e
INO80 complex subunit E
chr2_+_30364227 0.398 ENSMUST00000077977.7
ENSMUST00000140075.2
Fam73b

family with sequence similarity 73, member B

chr10_+_80292453 0.374 ENSMUST00000068408.7
ENSMUST00000062674.6
Rps15

ribosomal protein S15

chrX_+_99821021 0.373 ENSMUST00000096363.2
Tmem28
transmembrane protein 28
chr19_-_6128208 0.336 ENSMUST00000025702.7
Snx15
sorting nexin 15
chr7_-_29954049 0.336 ENSMUST00000108211.1
ENSMUST00000108205.1
Zfp74

zinc finger protein 74

chr5_-_138170992 0.326 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr2_-_3419066 0.323 ENSMUST00000115082.3
Meig1
meiosis expressed gene 1
chr10_-_62578387 0.322 ENSMUST00000162525.1
ENSMUST00000159704.1
ENSMUST00000162759.1
ENSMUST00000065887.7
2510003E04Rik



RIKEN cDNA 2510003E04 gene



chr8_+_105701142 0.318 ENSMUST00000098444.2
Pard6a
par-6 (partitioning defective 6,) homolog alpha (C. elegans)
chr17_+_6270475 0.314 ENSMUST00000088940.4
Tmem181a
transmembrane protein 181A
chr19_+_5425121 0.306 ENSMUST00000159759.1
AI837181
expressed sequence AI837181
chr7_-_13034722 0.305 ENSMUST00000005711.4
Chmp2a
charged multivesicular body protein 2A
chr19_-_20727533 0.302 ENSMUST00000025656.3
Aldh1a7
aldehyde dehydrogenase family 1, subfamily A7
chr19_-_44555398 0.297 ENSMUST00000167027.1
ENSMUST00000171415.1
ENSMUST00000026222.4
Ndufb8


NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8


chr6_-_113377712 0.285 ENSMUST00000113107.1
ENSMUST00000113106.1
Tada3

transcriptional adaptor 3

chr4_-_117156144 0.266 ENSMUST00000102696.4
Rps8
ribosomal protein S8
chr11_-_6267718 0.256 ENSMUST00000004507.4
ENSMUST00000151446.1
Ddx56

DEAD (Asp-Glu-Ala-Asp) box polypeptide 56

chr2_-_121442574 0.244 ENSMUST00000116432.1
Ell3
elongation factor RNA polymerase II-like 3
chr1_+_133131143 0.232 ENSMUST00000052529.3
Ppp1r15b
protein phosphatase 1, regulatory (inhibitor) subunit 15b
chr6_-_113377510 0.219 ENSMUST00000099118.2
Tada3
transcriptional adaptor 3
chr11_-_70982987 0.201 ENSMUST00000078528.6
C1qbp
complement component 1, q subcomponent binding protein
chr13_-_74807913 0.200 ENSMUST00000065629.4
Cast
calpastatin
chr9_+_14860210 0.174 ENSMUST00000034408.5
ENSMUST00000115624.2
Gpr83

G protein-coupled receptor 83

chr8_+_12984246 0.166 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
Mcf2l


mcf.2 transforming sequence-like


chr16_+_32099781 0.154 ENSMUST00000115168.2
Cep19
centrosomal protein 19
chr1_-_135284075 0.153 ENSMUST00000077340.7
ENSMUST00000074357.7
Rnpep

arginyl aminopeptidase (aminopeptidase B)

chr1_+_179546303 0.140 ENSMUST00000040706.8
Cnst
consortin, connexin sorting protein
chr13_+_21945084 0.135 ENSMUST00000176511.1
ENSMUST00000102978.1
ENSMUST00000152258.2
Zfp184


zinc finger protein 184 (Kruppel-like)


chr17_-_56074542 0.122 ENSMUST00000139371.1
Ubxn6
UBX domain protein 6
chr11_-_45955465 0.121 ENSMUST00000011398.6
Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr2_-_167043494 0.118 ENSMUST00000067584.6
Znfx1
zinc finger, NFX1-type containing 1
chr9_+_55326913 0.106 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr3_+_137918526 0.096 ENSMUST00000168345.1
Lamtor3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
chr5_+_129941949 0.078 ENSMUST00000051758.7
ENSMUST00000073945.4
Vkorc1l1

vitamin K epoxide reductase complex, subunit 1-like 1

chr7_+_128062657 0.076 ENSMUST00000120355.1
ENSMUST00000106240.2
ENSMUST00000098015.3
Itgam


integrin alpha M


chr1_-_133131782 0.076 ENSMUST00000180528.1
Gm26616
predicted gene, 26616
chr11_-_118248590 0.070 ENSMUST00000106305.2
Cyth1
cytohesin 1
chr4_-_117914968 0.068 ENSMUST00000036156.5
Ipo13
importin 13
chrX_+_170009659 0.062 ENSMUST00000179760.1
Gm21887
predicted gene, 21887
chrY_-_6681243 0.061 ENSMUST00000115940.1
Gm21719
predicted gene, 21719
chr4_+_109000770 0.061 ENSMUST00000106644.2
Nrd1
nardilysin, N-arginine dibasic convertase, NRD convertase 1
chr1_+_85100164 0.053 ENSMUST00000097669.1
Gm10553
predicted gene 10553
chr9_+_110419750 0.040 ENSMUST00000035061.6
Ngp
neutrophilic granule protein
chr8_-_105701077 0.039 ENSMUST00000042608.6
Acd
adrenocortical dysplasia
chr4_+_115563649 0.039 ENSMUST00000141033.1
ENSMUST00000030486.8
ENSMUST00000126645.1
ENSMUST00000030480.3
Cyp4a31



cytochrome P450, family 4, subfamily a, polypeptide 31



chr1_-_80758536 0.022 ENSMUST00000077946.5
Dock10
dedicator of cytokinesis 10
chr16_+_32099904 0.018 ENSMUST00000042869.6
Cep19
centrosomal protein 19
chr2_+_55411790 0.015 ENSMUST00000155997.1
ENSMUST00000128307.1
Gm14033

predicted gene 14033

chr18_-_37997543 0.011 ENSMUST00000042944.7
Arap3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr3_-_94436574 0.004 ENSMUST00000029787.4
Oaz3
ornithine decarboxylase antizyme 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.8 GO:0009405 pathogenesis(GO:0009405)
0.9 15.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 2.4 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468)
0.6 1.8 GO:0098886 modification of dendritic spine(GO:0098886)
0.6 2.3 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.5 2.2 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.5 1.4 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.4 1.3 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.4 2.5 GO:0032796 uropod organization(GO:0032796)
0.4 1.2 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.4 1.6 GO:1903860 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
0.4 1.1 GO:0051715 cytolysis in other organism(GO:0051715)
0.4 1.9 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.4 1.1 GO:0043379 rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.3 3.1 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.3 13.4 GO:0034605 cellular response to heat(GO:0034605)
0.2 1.2 GO:0060161 histone H4-R3 methylation(GO:0043985) positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.2 1.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.2 1.9 GO:0051014 actin filament severing(GO:0051014)
0.2 1.8 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 1.2 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.2 0.6 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.2 1.1 GO:0006561 proline biosynthetic process(GO:0006561)
0.1 1.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 1.2 GO:0010764 negative regulation of fibroblast migration(GO:0010764) negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.1 1.1 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.6 GO:0051182 coenzyme transport(GO:0051182)
0.1 1.0 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 0.3 GO:1903722 regulation of centriole elongation(GO:1903722)
0.1 0.9 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 0.6 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 0.6 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.2 GO:2000510 regulation of MDA-5 signaling pathway(GO:0039533) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.1 0.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.4 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 1.9 GO:0014047 glutamate secretion(GO:0014047)
0.0 0.1 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 0.2 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.0 0.8 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 0.2 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 3.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 3.0 GO:0060113 inner ear receptor cell differentiation(GO:0060113)
0.0 6.4 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 0.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.9 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 2.2 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.2 GO:0007343 egg activation(GO:0007343)
0.0 1.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.7 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.1 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.3 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.0 0.0 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.0 0.6 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.1 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.0 0.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 1.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.0 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.7 GO:0071805 potassium ion transmembrane transport(GO:0071805)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.4 1.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.2 1.2 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.2 2.5 GO:0032426 stereocilium tip(GO:0032426)
0.2 1.8 GO:0034709 methylosome(GO:0034709)
0.2 0.8 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2 1.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 2.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 15.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 1.1 GO:0033391 chromatoid body(GO:0033391)
0.1 1.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 5.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.5 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 3.2 GO:0016592 mediator complex(GO:0016592)
0.1 0.6 GO:0089701 U2AF(GO:0089701)
0.1 0.9 GO:0031209 SCAR complex(GO:0031209)
0.1 1.8 GO:0031430 M band(GO:0031430)
0.1 1.0 GO:0000124 SAGA complex(GO:0000124)
0.1 3.3 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 0.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 2.8 GO:0031941 filamentous actin(GO:0031941)
0.1 0.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 1.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.2 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 4.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.6 GO:0055037 recycling endosome(GO:0055037)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.3 GO:0005604 basement membrane(GO:0005604)
0.0 0.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0032052 bile acid binding(GO:0032052)
0.6 2.3 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.6 1.7 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.4 2.4 GO:0050544 arachidonic acid binding(GO:0050544)
0.4 1.9 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.3 1.2 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.3 1.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.3 1.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.2 1.2 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.2 2.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 1.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.2 5.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 1.9 GO:0005522 profilin binding(GO:0005522)
0.1 0.6 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 2.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.6 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.5 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.5 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 1.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 2.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.9 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 1.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 0.6 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 12.8 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.2 GO:0030984 kininogen binding(GO:0030984)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.6 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 1.8 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.8 GO:0043274 phospholipase binding(GO:0043274)
0.0 1.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 1.9 GO:0019003 GDP binding(GO:0019003)
0.0 3.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.1 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 3.2 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 1.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.3 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 6.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0001851 complement component C3b binding(GO:0001851)
0.0 1.4 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 11.0 GO:0003682 chromatin binding(GO:0003682)
0.0 0.6 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 1.4 GO:0051087 chaperone binding(GO:0051087)
0.0 1.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.0 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.2 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.3 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0008026 ATP-dependent DNA helicase activity(GO:0004003) ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 1.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.8 PID_MYC_PATHWAY C-MYC pathway
0.0 1.5 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.3 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.2 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.1 PID_LKB1_PATHWAY LKB1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.5 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.2 1.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 6.4 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 1.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.2 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 2.1 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 3.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 0.6 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 1.1 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 3.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.8 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 1.4 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 2.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.5 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.6 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription