Motif ID: Tbx21

Z-value: 0.894


Transcription factors associated with Tbx21:

Gene SymbolEntrez IDGene Name
Tbx21 ENSMUSG00000001444.2 Tbx21



Activity profile for motif Tbx21.

activity profile for motif Tbx21


Sorted Z-values histogram for motif Tbx21

Sorted Z-values for motif Tbx21



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx21

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 136 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56969827 7.572 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969864 7.559 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr9_-_112185726 6.970 ENSMUST00000160240.1
ENSMUST00000162065.1
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr9_-_112185939 5.825 ENSMUST00000070218.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr18_+_67088287 5.485 ENSMUST00000025402.7
 Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr10_-_13868932 3.973 ENSMUST00000019942.5
ENSMUST00000162610.1
 Aig1

androgen-induced 1

chr10_-_13868779 3.683 ENSMUST00000105534.3
 Aig1
androgen-induced 1
chr19_+_12460749 3.627 ENSMUST00000081035.7
 Mpeg1
macrophage expressed gene 1
chr11_-_74590065 3.234 ENSMUST00000145524.1
ENSMUST00000047488.7
 Rap1gap2

RAP1 GTPase activating protein 2

chr11_-_74590186 3.206 ENSMUST00000102521.1
 Rap1gap2
RAP1 GTPase activating protein 2
chr18_+_37020097 3.107 ENSMUST00000047614.1
 Pcdha2
protocadherin alpha 2
chr7_+_45785331 3.013 ENSMUST00000120005.1
ENSMUST00000123585.1
 Lmtk3

lemur tyrosine kinase 3

chrX_-_152769461 2.802 ENSMUST00000101141.2
ENSMUST00000062317.4
 Shroom2

shroom family member 2

chr7_-_4789541 2.649 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr16_+_8470763 2.536 ENSMUST00000046470.9
ENSMUST00000150790.1
ENSMUST00000142899.1
 Mettl22


methyltransferase like 22


chr7_-_126704816 2.500 ENSMUST00000032949.7
 Coro1a
coronin, actin binding protein 1A
chr6_-_60829826 2.374 ENSMUST00000163779.1
 Snca
synuclein, alpha
chr8_-_68735058 2.286 ENSMUST00000136060.1
ENSMUST00000130214.1
ENSMUST00000078350.6
 Csgalnact1


chondroitin sulfate N-acetylgalactosaminyltransferase 1


chr1_+_34801704 2.241 ENSMUST00000047664.9
 Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr10_-_75560330 2.147 ENSMUST00000051129.9
 Fam211b
family with sequence similarity 211, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 15.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 13.4 GO:0034605 cellular response to heat(GO:0034605)
0.0 6.4 GO:0010977 negative regulation of neuron projection development(GO:0010977)
1.0 5.8 GO:0009405 pathogenesis(GO:0009405)
0.3 3.1 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.0 3.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 3.0 GO:0060113 inner ear receptor cell differentiation(GO:0060113)
0.4 2.5 GO:0032796 uropod organization(GO:0032796)
0.6 2.4 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468)
0.6 2.3 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.5 2.2 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 2.2 GO:0046847 filopodium assembly(GO:0046847)
0.4 1.9 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.2 1.9 GO:0051014 actin filament severing(GO:0051014)
0.1 1.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 1.9 GO:0014047 glutamate secretion(GO:0014047)
0.6 1.8 GO:0098886 modification of dendritic spine(GO:0098886)
0.2 1.8 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 1.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.7 GO:0071805 potassium ion transmembrane transport(GO:0071805)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 5.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 4.0 GO:0031965 nuclear membrane(GO:0031965)
0.1 3.3 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 3.2 GO:0016592 mediator complex(GO:0016592)
0.1 2.8 GO:0031941 filamentous actin(GO:0031941)
0.2 2.5 GO:0032426 stereocilium tip(GO:0032426)
0.6 2.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 2.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.8 GO:0034709 methylosome(GO:0034709)
0.1 1.8 GO:0031430 M band(GO:0031430)
0.0 1.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.6 GO:0055037 recycling endosome(GO:0055037)
0.1 1.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 1.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.3 GO:0005604 basement membrane(GO:0005604)
0.2 1.2 GO:0048476 Holliday junction resolvase complex(GO:0048476)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.8 GO:0005516 calmodulin binding(GO:0005516)
0.0 11.0 GO:0003682 chromatin binding(GO:0003682)
0.0 6.2 GO:0005096 GTPase activator activity(GO:0005096)
0.2 5.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 3.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 3.2 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.2 2.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.4 2.4 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 2.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.6 2.3 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.7 2.2 GO:0032052 bile acid binding(GO:0032052)
0.1 2.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 2.1 GO:0008276 protein methyltransferase activity(GO:0008276)
0.4 1.9 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 1.9 GO:0005522 profilin binding(GO:0005522)
0.0 1.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.9 GO:0019003 GDP binding(GO:0019003)
0.0 1.8 GO:0030507 spectrin binding(GO:0030507)
0.0 1.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.6 1.7 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 1.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.5 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 1.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 1.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.2 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.1 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.8 PID_MYC_PATHWAY C-MYC pathway
0.0 0.3 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.4 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
1.1 5.5 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 3.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 3.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.2 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 2.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.1 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.8 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 1.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 1.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.4 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.1 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 0.6 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.6 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription