Motif ID: Tbx4

Z-value: 1.061


Transcription factors associated with Tbx4:

Gene SymbolEntrez IDGene Name
Tbx4 ENSMUSG00000000094.6 Tbx4



Activity profile for motif Tbx4.

activity profile for motif Tbx4


Sorted Z-values histogram for motif Tbx4

Sorted Z-values for motif Tbx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 113 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 21.210 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_+_6730051 15.687 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr1_-_138847579 15.145 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr6_+_15196949 10.676 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr17_+_29093763 9.703 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr7_-_28302238 9.067 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr1_+_6730135 8.584 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr6_+_7555053 6.721 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr2_+_164562579 6.073 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr11_-_84068357 5.976 ENSMUST00000100705.4
 Dusp14
dual specificity phosphatase 14
chr2_-_13011747 5.848 ENSMUST00000061545.5
 C1ql3
C1q-like 3
chr19_+_20601958 5.576 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr11_-_84068766 5.532 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr7_-_115824699 5.479 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr18_-_46212595 5.183 ENSMUST00000037011.4
 Trim36
tripartite motif-containing 36
chr5_+_115908644 5.174 ENSMUST00000141101.1
 Cit
citron
chr18_+_5591860 5.082 ENSMUST00000025081.5
ENSMUST00000159390.1
 Zeb1

zinc finger E-box binding homeobox 1

chr4_-_134018829 4.881 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr9_-_43239816 4.825 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr1_+_132316112 4.734 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 24.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
3.0 15.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.9 12.9 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.3 11.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.9 10.7 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.1 9.7 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 9.5 GO:0010466 negative regulation of peptidase activity(GO:0010466)
1.8 9.1 GO:0007386 compartment pattern specification(GO:0007386)
2.2 6.7 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.2 5.8 GO:0007129 synapsis(GO:0007129)
1.4 5.6 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.5 5.5 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 5.5 GO:0007340 acrosome reaction(GO:0007340)
0.3 5.2 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.6 5.1 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 5.0 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.5 4.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 4.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.3 4.3 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.8 3.2 GO:0030091 protein repair(GO:0030091)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.8 GO:0032993 protein-DNA complex(GO:0032993)
0.3 12.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 11.7 GO:0005667 transcription factor complex(GO:0005667)
3.2 9.7 GO:0070557 PCNA-p21 complex(GO:0070557)
2.0 5.9 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 5.9 GO:0005581 collagen trimer(GO:0005581)
0.1 5.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 5.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 5.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 4.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.9 3.4 GO:0031983 vesicle lumen(GO:0031983)
0.1 3.1 GO:0001741 XY body(GO:0001741)
0.5 3.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 2.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.4 GO:0031965 nuclear membrane(GO:0031965)
0.2 1.9 GO:0031415 NatA complex(GO:0031415)
0.0 1.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.8 GO:0016605 PML body(GO:0016605)
0.1 1.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.7 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.0 GO:0001047 core promoter binding(GO:0001047)
0.1 15.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 12.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.8 11.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
3.2 9.7 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.3 9.1 GO:0005112 Notch binding(GO:0005112)
0.0 7.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 6.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 6.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 6.4 GO:0070888 E-box binding(GO:0070888)
1.2 6.1 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
1.1 5.6 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.4 4.9 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.3 4.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 4.7 GO:0000287 magnesium ion binding(GO:0000287)
0.1 3.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.4 GO:0097110 scaffold protein binding(GO:0097110)
0.5 3.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.4 3.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.4 3.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 9.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 9.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.4 5.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 4.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 4.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 3.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.9 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 2.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 2.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.0 PID_FGF_PATHWAY FGF signaling pathway
0.1 1.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.7 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.2 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.3 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.4 9.7 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 6.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 5.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
1.4 5.6 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 5.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 4.7 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 2.9 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.1 2.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 2.0 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 1.7 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 1.7 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 1.3 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.2 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.2 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.7 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.3 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.1 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly