Motif ID: Tbx4

Z-value: 1.061


Transcription factors associated with Tbx4:

Gene SymbolEntrez IDGene Name
Tbx4 ENSMUSG00000000094.6 Tbx4



Activity profile for motif Tbx4.

activity profile for motif Tbx4


Sorted Z-values histogram for motif Tbx4

Sorted Z-values for motif Tbx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_26229707 21.210 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr1_+_6730051 15.687 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
St18



suppression of tumorigenicity 18



chr1_-_138847579 15.145 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9

LIM homeobox protein 9

chr6_+_15196949 10.676 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
Foxp2



forkhead box P2



chr17_+_29093763 9.703 ENSMUST00000023829.6
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr7_-_28302238 9.067 ENSMUST00000108315.3
Dll3
delta-like 3 (Drosophila)
chr1_+_6730135 8.584 ENSMUST00000155921.1
St18
suppression of tumorigenicity 18
chr6_+_7555053 6.721 ENSMUST00000090679.2
ENSMUST00000184986.1
Tac1

tachykinin 1

chr2_+_164562579 6.073 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
Wfdc2


WAP four-disulfide core domain 2


chr11_-_84068357 5.976 ENSMUST00000100705.4
Dusp14
dual specificity phosphatase 14
chr2_-_13011747 5.848 ENSMUST00000061545.5
C1ql3
C1q-like 3
chr19_+_20601958 5.576 ENSMUST00000087638.3
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr11_-_84068766 5.532 ENSMUST00000018792.5
Dusp14
dual specificity phosphatase 14
chr7_-_115824699 5.479 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr18_-_46212595 5.183 ENSMUST00000037011.4
Trim36
tripartite motif-containing 36
chr5_+_115908644 5.174 ENSMUST00000141101.1
Cit
citron
chr18_+_5591860 5.082 ENSMUST00000025081.5
ENSMUST00000159390.1
Zeb1

zinc finger E-box binding homeobox 1

chr4_-_134018829 4.881 ENSMUST00000051674.2
Lin28a
lin-28 homolog A (C. elegans)
chr9_-_43239816 4.825 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr1_+_132316112 4.734 ENSMUST00000082125.5
ENSMUST00000072177.7
Nuak2

NUAK family, SNF1-like kinase, 2

chr13_-_89742490 4.726 ENSMUST00000109546.2
Vcan
versican
chrX_-_53269020 4.275 ENSMUST00000114838.1
Fam122b
family with sequence similarity 122, member B
chr11_-_115813621 4.167 ENSMUST00000041684.4
ENSMUST00000156812.1
Caskin2

CASK-interacting protein 2

chr1_+_153665274 3.938 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr4_+_11191726 3.678 ENSMUST00000029866.9
ENSMUST00000108324.3
Ccne2

cyclin E2

chr1_+_153665666 3.582 ENSMUST00000111814.1
ENSMUST00000111810.1
Rgs8

regulator of G-protein signaling 8

chr3_+_75557530 3.438 ENSMUST00000161776.1
ENSMUST00000029423.8
Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr10_-_120899067 3.191 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chr2_-_60125651 3.158 ENSMUST00000112550.1
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr12_+_3891728 3.137 ENSMUST00000172689.1
ENSMUST00000111186.1
Dnmt3a

DNA methyltransferase 3A

chr14_+_62292475 3.021 ENSMUST00000166879.1
Rnaseh2b
ribonuclease H2, subunit B
chr6_-_94700137 2.872 ENSMUST00000101126.2
ENSMUST00000032105.4
Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr1_+_153665587 2.697 ENSMUST00000147700.1
Rgs8
regulator of G-protein signaling 8
chr1_+_153665627 2.648 ENSMUST00000147482.1
Rgs8
regulator of G-protein signaling 8
chr16_-_50330987 2.588 ENSMUST00000114488.1
Bbx
bobby sox homolog (Drosophila)
chr1_-_105356658 2.553 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152

ring finger protein 152

chr7_-_141443989 2.527 ENSMUST00000026580.5
Lrdd
leucine-rich and death domain containing
chr9_+_35421541 2.444 ENSMUST00000119129.2
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr14_-_51988829 2.337 ENSMUST00000181008.1
Gm16617
predicted gene, 16617
chr4_+_11191354 2.221 ENSMUST00000170901.1
Ccne2
cyclin E2
chrX_-_162829379 1.991 ENSMUST00000041370.4
ENSMUST00000112316.2
ENSMUST00000112315.1
Txlng


taxilin gamma


chr14_-_70642268 1.959 ENSMUST00000022697.5
Fgf17
fibroblast growth factor 17
chr3_+_51415986 1.876 ENSMUST00000029303.7
Naa15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr4_-_42168603 1.750 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chr8_-_31918203 1.732 ENSMUST00000073884.4
Nrg1
neuregulin 1
chr10_-_86705485 1.671 ENSMUST00000020238.7
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr13_-_96542479 1.418 ENSMUST00000022172.4
Polk
polymerase (DNA directed), kappa
chr15_+_57694651 1.386 ENSMUST00000096430.4
Zhx2
zinc fingers and homeoboxes 2
chr9_+_48495345 1.371 ENSMUST00000048824.7
Gm5617
predicted gene 5617
chr10_-_85916902 1.297 ENSMUST00000037646.7
Prdm4
PR domain containing 4
chr9_-_95845215 1.290 ENSMUST00000093800.2
Pls1
plastin 1 (I-isoform)
chr12_-_56345862 1.259 ENSMUST00000021416.7
Mbip
MAP3K12 binding inhibitory protein 1
chr2_+_54436317 1.236 ENSMUST00000112636.1
ENSMUST00000112635.1
ENSMUST00000112634.1
Galnt13


UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13


chr19_+_55894508 1.215 ENSMUST00000142291.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chrX_+_42151002 1.171 ENSMUST00000123245.1
Stag2
stromal antigen 2
chrX_+_20425688 1.170 ENSMUST00000115384.2
Phf16
PHD finger protein 16
chr2_+_52857844 1.133 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
Fmnl2


formin-like 2


chr3_-_103791537 1.122 ENSMUST00000118317.1
Hipk1
homeodomain interacting protein kinase 1
chr9_+_108296853 1.041 ENSMUST00000035230.5
Amt
aminomethyltransferase
chrM_+_9452 0.919 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr9_-_48495321 0.914 ENSMUST00000170000.2
Rbm7
RNA binding motif protein 7
chr19_-_42202150 0.912 ENSMUST00000018966.7
Sfrp5
secreted frizzled-related sequence protein 5
chr4_-_36056726 0.886 ENSMUST00000108124.3
Lingo2
leucine rich repeat and Ig domain containing 2
chrM_+_9870 0.868 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr5_+_120513102 0.849 ENSMUST00000111889.1
Slc8b1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr3_-_75556759 0.815 ENSMUST00000162138.1
ENSMUST00000029424.5
ENSMUST00000161137.1
Pdcd10


programmed cell death 10


chr11_-_98149551 0.793 ENSMUST00000103143.3
Fbxl20
F-box and leucine-rich repeat protein 20
chr4_-_72852622 0.784 ENSMUST00000179234.1
ENSMUST00000078617.4
Aldoart1

aldolase 1 A, retrogene 1

chr13_+_96542727 0.765 ENSMUST00000077672.4
ENSMUST00000109444.2
Col4a3bp

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr1_-_24612700 0.750 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr15_-_10470490 0.747 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr3_-_103791075 0.710 ENSMUST00000106845.2
ENSMUST00000029438.8
ENSMUST00000121324.1
Hipk1


homeodomain interacting protein kinase 1


chr2_+_103970221 0.707 ENSMUST00000111140.2
ENSMUST00000111139.2
Lmo2

LIM domain only 2

chr7_-_46795661 0.688 ENSMUST00000123725.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr15_-_38300693 0.678 ENSMUST00000074043.5
Klf10
Kruppel-like factor 10
chr6_-_28261907 0.662 ENSMUST00000115320.1
ENSMUST00000123098.1
ENSMUST00000115321.2
ENSMUST00000155494.1
Zfp800



zinc finger protein 800



chr2_+_103970115 0.657 ENSMUST00000111143.1
ENSMUST00000138815.1
Lmo2

LIM domain only 2

chr9_+_44326804 0.653 ENSMUST00000054708.3
Dpagt1
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr9_-_69760924 0.637 ENSMUST00000071281.4
Foxb1
forkhead box B1
chrM_+_10167 0.597 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr7_-_46795881 0.554 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr13_+_80886095 0.525 ENSMUST00000161441.1
Arrdc3
arrestin domain containing 3
chr6_+_29398920 0.510 ENSMUST00000181464.1
ENSMUST00000180829.1
Ccdc136

coiled-coil domain containing 136

chr11_-_78751656 0.496 ENSMUST00000059468.4
Fam58b
family with sequence similarity 58, member B
chr11_-_94507337 0.478 ENSMUST00000040692.8
Mycbpap
MYCBP associated protein
chr4_+_43641262 0.477 ENSMUST00000123351.1
ENSMUST00000128549.1
Npr2

natriuretic peptide receptor 2

chr13_-_111490028 0.430 ENSMUST00000091236.4
Gpbp1
GC-rich promoter binding protein 1
chr19_-_28963863 0.415 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr11_-_20741447 0.395 ENSMUST00000177543.1
Aftph
aftiphilin
chr5_+_31094984 0.373 ENSMUST00000066505.1
Gm9924
predicted gene 9924
chr2_+_138278481 0.363 ENSMUST00000075410.4
Btbd3
BTB (POZ) domain containing 3
chr1_+_74542881 0.363 ENSMUST00000113749.1
ENSMUST00000067916.6
ENSMUST00000113745.1
ENSMUST00000113747.1
ENSMUST00000113750.1
Plcd4




phospholipase C, delta 4




chr8_+_79028317 0.341 ENSMUST00000087927.4
ENSMUST00000098614.2
Zfp827

zinc finger protein 827

chr14_+_31251454 0.340 ENSMUST00000022458.4
Bap1
Brca1 associated protein 1
chr11_+_78178105 0.311 ENSMUST00000147819.1
Tlcd1
TLC domain containing 1
chr11_-_69900949 0.296 ENSMUST00000102580.3
2810408A11Rik
RIKEN cDNA 2810408A11 gene
chr11_-_86544754 0.283 ENSMUST00000138810.1
ENSMUST00000058286.2
ENSMUST00000154617.1
Rps6kb1


ribosomal protein S6 kinase, polypeptide 1


chr2_-_57114970 0.281 ENSMUST00000028166.2
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr4_+_84884418 0.262 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr7_-_99858872 0.258 ENSMUST00000036274.6
Spcs2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr6_+_42286676 0.230 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr2_-_148045891 0.229 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr16_+_62814676 0.222 ENSMUST00000055557.5
Stx19
syntaxin 19
chr4_+_148000722 0.182 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr8_+_45885479 0.173 ENSMUST00000034053.5
Pdlim3
PDZ and LIM domain 3
chrX_+_101383726 0.146 ENSMUST00000119190.1
Gjb1
gap junction protein, beta 1
chr10_+_96136603 0.132 ENSMUST00000074615.6
Gm5426
predicted pseudogene 5426
chr18_+_65582390 0.114 ENSMUST00000169679.1
ENSMUST00000183326.1
Zfp532

zinc finger protein 532

chr10_+_86705811 0.105 ENSMUST00000061458.7
ENSMUST00000075632.6
BC030307

cDNA sequence BC030307

chr1_+_66468364 0.083 ENSMUST00000061620.9
Unc80
unc-80 homolog (C. elegans)
chr17_-_78937031 0.079 ENSMUST00000024885.8
Cebpz
CCAAT/enhancer binding protein zeta
chr6_+_42286709 0.074 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr15_+_10952332 0.053 ENSMUST00000022853.8
ENSMUST00000110523.1
C1qtnf3

C1q and tumor necrosis factor related protein 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 15.1 GO:0035262 gonad morphogenesis(GO:0035262)
2.2 6.7 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
2.0 24.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.8 9.1 GO:0007386 compartment pattern specification(GO:0007386)
1.4 5.6 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
1.1 9.7 GO:0071493 cellular response to UV-B(GO:0071493)
1.0 2.9 GO:0032474 otolith morphogenesis(GO:0032474)
0.9 12.9 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.9 10.7 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.8 3.2 GO:0030091 protein repair(GO:0030091)
0.6 5.1 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.5 4.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.5 5.5 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.4 1.3 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.4 3.1 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.3 1.0 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.3 11.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.3 4.3 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.3 0.9 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.3 0.8 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.3 1.9 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.3 5.2 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.2 1.7 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.2 5.5 GO:0007340 acrosome reaction(GO:0007340)
0.2 1.3 GO:0051189 molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.2 1.4 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.2 0.6 GO:0035621 ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627)
0.2 0.5 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.2 2.6 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.2 0.6 GO:0007412 axon target recognition(GO:0007412)
0.2 5.8 GO:0007129 synapsis(GO:0007129)
0.2 1.7 GO:0071318 cellular response to ATP(GO:0071318)
0.2 1.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 4.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 1.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 3.0 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 1.4 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.3 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 0.3 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 0.7 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 5.0 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.3 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 0.7 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 9.5 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 1.1 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.5 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 2.1 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.0 0.5 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.3 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 2.0 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 2.0 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 0.1 GO:0015868 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.0 0.9 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 1.2 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.8 GO:0002209 behavioral fear response(GO:0001662) behavioral defense response(GO:0002209)
0.0 0.0 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.3 GO:0006465 signal peptide processing(GO:0006465)
0.0 2.6 GO:0060348 bone development(GO:0060348)
0.0 0.2 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.1 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 1.2 GO:0043473 pigmentation(GO:0043473)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.7 GO:0070557 PCNA-p21 complex(GO:0070557)
2.0 5.9 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.9 3.4 GO:0031983 vesicle lumen(GO:0031983)
0.5 3.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 12.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 1.2 GO:0031084 BLOC-2 complex(GO:0031084)
0.3 1.3 GO:1990357 terminal web(GO:1990357)
0.2 1.9 GO:0031415 NatA complex(GO:0031415)
0.1 1.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 3.1 GO:0001741 XY body(GO:0001741)
0.1 20.8 GO:0032993 protein-DNA complex(GO:0032993)
0.1 0.4 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 5.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 5.9 GO:0005581 collagen trimer(GO:0005581)
0.1 1.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 4.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 5.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 0.8 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.7 GO:0030673 axolemma(GO:0030673)
0.0 1.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.0 11.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)
0.0 5.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.8 GO:0016605 PML body(GO:0016605)
0.0 1.3 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.6 GO:0070469 respiratory chain(GO:0070469)
0.0 0.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.4 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.1 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.7 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.2 6.1 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
1.1 5.6 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.8 11.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.7 2.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.5 3.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.4 4.9 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.4 3.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.4 3.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.3 6.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.3 12.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 4.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 9.1 GO:0005112 Notch binding(GO:0005112)
0.2 0.8 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.2 1.7 GO:0046790 virion binding(GO:0046790)
0.2 6.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 0.7 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 6.4 GO:0070888 E-box binding(GO:0070888)
0.1 1.9 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 1.7 GO:0045499 chemorepellent activity(GO:0045499)
0.1 15.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 23.0 GO:0001047 core promoter binding(GO:0001047)
0.1 1.3 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 1.3 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 0.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 1.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 3.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.0 GO:0008483 transaminase activity(GO:0008483)
0.0 3.4 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0097001 ceramide binding(GO:0097001)
0.0 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.5 GO:0031690 adrenergic receptor binding(GO:0031690)
0.0 4.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.0 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)
0.0 7.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.2 GO:0008307 structural constituent of muscle(GO:0008307)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 9.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 5.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 2.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 4.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 1.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 9.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 5.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 2.9 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 3.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 4.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.7 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 2.0 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 3.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.3 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 1.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.6 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.4 9.7 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 4.7 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 2.0 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 5.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 1.7 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 1.7 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.2 6.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.9 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.1 12.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 2.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.2 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.7 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 5.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.3 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 1.2 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.1 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 1.3 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling