Motif ID: Tbx5

Z-value: 0.700


Transcription factors associated with Tbx5:

Gene SymbolEntrez IDGene Name
Tbx5 ENSMUSG00000018263.8 Tbx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx5mm10_v2_chr5_+_119834663_1198346630.076.7e-01Click!


Activity profile for motif Tbx5.

activity profile for motif Tbx5


Sorted Z-values histogram for motif Tbx5

Sorted Z-values for motif Tbx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 6.200 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_-_138848576 4.959 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr7_-_28302238 3.383 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr14_+_122475397 3.379 ENSMUST00000075888.5
 Zic2
zinc finger protein of the cerebellum 2
chr10_+_93641041 2.743 ENSMUST00000020204.4
 Ntn4
netrin 4
chr5_-_5514730 2.703 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
 Cldn12



claudin 12



chr3_+_126596993 2.618 ENSMUST00000163226.1
ENSMUST00000066466.6
ENSMUST00000169051.1
 Camk2d


calcium/calmodulin-dependent protein kinase II, delta


chr3_+_126596951 2.550 ENSMUST00000106402.1
 Camk2d
calcium/calmodulin-dependent protein kinase II, delta
chr3_+_108383829 2.470 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
 Psrc1


proline/serine-rich coiled-coil 1


chrX_+_100625737 2.339 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr5_-_5514873 2.305 ENSMUST00000060947.7
 Cldn12
claudin 12
chr4_+_128883549 2.214 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62
chr9_-_43239816 2.018 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr3_+_126597299 2.000 ENSMUST00000106400.2
ENSMUST00000106401.1
 Camk2d

calcium/calmodulin-dependent protein kinase II, delta

chr18_+_35829798 1.941 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5
chr15_-_98004634 1.884 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr4_-_134018829 1.766 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr15_-_98004695 1.725 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr18_-_46212595 1.639 ENSMUST00000037011.4
 Trim36
tripartite motif-containing 36
chr17_-_70851189 1.475 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 7.2 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
1.0 5.0 GO:0035262 gonad morphogenesis(GO:0035262)
0.3 3.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.8 3.4 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.7 3.4 GO:0007386 compartment pattern specification(GO:0007386)
0.5 2.7 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.3 2.6 GO:0010587 miRNA catabolic process(GO:0010587)
0.4 2.5 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 2.3 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.1 2.3 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.2 2.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.2 1.8 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 1.6 GO:0007340 acrosome reaction(GO:0007340)
0.1 1.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 1.4 GO:0030091 protein repair(GO:0030091)
0.1 1.4 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 1.4 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 1.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.4 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.4 1.3 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.4 GO:0043194 axon initial segment(GO:0043194)
0.1 5.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 4.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.1 GO:0005604 basement membrane(GO:0005604)
0.2 2.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 2.3 GO:0045171 intercellular bridge(GO:0045171)
0.2 2.1 GO:0002177 manchette(GO:0002177)
0.1 2.1 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 1.9 GO:0005876 spindle microtubule(GO:0005876)
0.3 1.3 GO:1990357 terminal web(GO:1990357)
0.0 1.3 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 1.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.4 1.1 GO:0035061 interchromatin granule(GO:0035061)
0.1 1.1 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)
0.1 1.0 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 0.7 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.2 GO:0031432 titin binding(GO:0031432)
0.0 6.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.7 3.6 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 3.4 GO:0005112 Notch binding(GO:0005112)
0.0 3.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 3.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 2.7 GO:0043237 laminin-1 binding(GO:0043237)
0.1 2.4 GO:0070888 E-box binding(GO:0070888)
0.0 2.4 GO:0004386 helicase activity(GO:0004386)
0.1 2.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 2.3 GO:0051015 actin filament binding(GO:0051015)
0.2 1.9 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 1.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.5 GO:0070410 co-SMAD binding(GO:0070410)
0.2 1.4 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 1.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 1.3 GO:0051378 serotonin binding(GO:0051378)
0.1 1.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.2 GO:0031491 nucleosome binding(GO:0031491)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 4.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.0 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.7 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.6 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.5 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 5.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 5.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 2.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.5 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.0 1.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.1 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 1.0 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.0 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.7 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.6 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.6 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.6 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.5 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle