Motif ID: Tcf3
Z-value: 0.591
Transcription factors associated with Tcf3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tcf3 | ENSMUSG00000020167.8 | Tcf3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tcf3 | mm10_v2_chr10_-_80433615_80433655 | 0.44 | 6.1e-03 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 188 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 5.1 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.3 | 4.0 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.3 | 3.0 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.4 | 2.9 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.3 | 2.5 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.6 | 2.4 | GO:0060032 | notochord regression(GO:0060032) |
| 0.1 | 2.3 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.1 | 2.2 | GO:0045780 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 0.2 | 2.1 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.1 | 2.1 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.2 | 2.0 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) regulation of skeletal muscle fiber development(GO:0048742) |
| 0.1 | 2.0 | GO:0030903 | notochord development(GO:0030903) |
| 0.0 | 2.0 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.0 | 1.6 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.3 | 1.5 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.1 | 1.5 | GO:0001977 | renal system process involved in regulation of blood volume(GO:0001977) |
| 0.1 | 1.5 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.1 | 1.4 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
| 0.1 | 1.4 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
| 0.3 | 1.3 | GO:0010637 | negative regulation of mitochondrial fusion(GO:0010637) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 74 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 2.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.2 | 2.6 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 2.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.2 | 2.4 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.5 | 2.3 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.0 | 1.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 1.7 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.0 | 1.6 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 1.5 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.5 | 1.4 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.0 | 1.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.4 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 1.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.4 | 1.3 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
| 0.3 | 1.2 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 1.0 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 1.0 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 1.0 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.1 | 0.9 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 113 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.2 | GO:0005112 | Notch binding(GO:0005112) |
| 0.5 | 4.8 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 4.0 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 3.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 3.0 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.9 | 2.6 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.1 | 2.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 2.1 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.1 | 2.1 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 2.0 | GO:0051861 | glycolipid binding(GO:0051861) |
| 0.1 | 2.0 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 1.8 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 1.8 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.4 | 1.6 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.2 | 1.6 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 1.6 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 1.5 | GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764) |
| 0.1 | 1.4 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.0 | 1.4 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 1.4 | GO:0002020 | protease binding(GO:0002020) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 38 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 2.5 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 2.4 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 2.3 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.1 | 2.2 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 2.0 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 1.7 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
| 0.0 | 1.7 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.1 | 1.4 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 1.3 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.1 | 1.2 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 1.2 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 1.2 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.2 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.0 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.0 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.9 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.9 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.8 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.7 | PID_LYMPH_ANGIOGENESIS_PATHWAY | VEGFR3 signaling in lymphatic endothelium |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 51 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.4 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 2.3 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.1 | 2.2 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 2.0 | REACTOME_SIGNALING_BY_NOTCH1 | Genes involved in Signaling by NOTCH1 |
| 0.1 | 1.9 | REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.1 | 1.6 | REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION | Genes involved in Incretin Synthesis, Secretion, and Inactivation |
| 0.0 | 1.4 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 1.2 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 1.2 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 1.2 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 1.2 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.2 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.1 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 0.9 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 0.9 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.9 | REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 0.9 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 0.7 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.7 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
