Motif ID: Tcf4_Mesp1
Z-value: 2.288
Transcription factors associated with Tcf4_Mesp1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Mesp1 | ENSMUSG00000030544.5 | Mesp1 |
| Tcf4 | ENSMUSG00000053477.9 | Tcf4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tcf4 | mm10_v2_chr18_+_69344503_69344530 | -0.33 | 4.7e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 593 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 47.0 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 1.3 | 46.5 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.3 | 32.8 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 9.3 | 27.9 | GO:2000111 | cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
| 0.2 | 20.8 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 2.9 | 20.5 | GO:0061092 | regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
| 0.4 | 20.3 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.2 | 19.9 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
| 3.8 | 18.9 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 4.6 | 18.4 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 3.3 | 16.5 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.8 | 16.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.3 | 15.9 | GO:0010812 | negative regulation of cell-substrate adhesion(GO:0010812) |
| 3.8 | 15.1 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.6 | 14.6 | GO:0043496 | regulation of protein homodimerization activity(GO:0043496) |
| 3.5 | 14.1 | GO:1902512 | positive regulation of apoptotic DNA fragmentation(GO:1902512) |
| 0.9 | 13.7 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 2.6 | 13.2 | GO:0075136 | response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136) |
| 0.2 | 13.2 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 1.4 | 13.0 | GO:0071420 | cellular response to histamine(GO:0071420) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 241 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 83.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.2 | 55.1 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.2 | 30.1 | GO:0030016 | myofibril(GO:0030016) |
| 0.9 | 25.7 | GO:0033268 | node of Ranvier(GO:0033268) |
| 1.1 | 21.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.3 | 19.8 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.7 | 19.3 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 18.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 1.4 | 18.2 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.9 | 17.9 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.2 | 15.7 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 14.5 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.9 | 14.2 | GO:1902710 | GABA receptor complex(GO:1902710) |
| 0.1 | 13.9 | GO:0001650 | fibrillar center(GO:0001650) |
| 3.4 | 13.5 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.3 | 13.2 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.4 | 13.0 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.3 | 12.9 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 4.1 | 12.2 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.8 | 11.8 | GO:0043196 | varicosity(GO:0043196) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 372 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 52.6 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 1.1 | 42.7 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.4 | 35.9 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 1.8 | 28.5 | GO:0003680 | AT DNA binding(GO:0003680) |
| 4.0 | 27.9 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.7 | 27.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 2.2 | 26.4 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
| 0.7 | 22.7 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.8 | 20.6 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 3.8 | 18.9 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 1.0 | 18.6 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 2.0 | 16.1 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 1.4 | 15.0 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.4 | 14.7 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.3 | 14.3 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.1 | 13.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 2.6 | 13.0 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.6 | 12.7 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.2 | 12.6 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.3 | 12.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 66 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 40.6 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.4 | 31.1 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.7 | 29.1 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.7 | 28.2 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.6 | 20.5 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 14.7 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 14.5 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.4 | 14.3 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.3 | 13.9 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.4 | 13.3 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.9 | 13.0 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.3 | 12.1 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.4 | 11.7 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.4 | 10.1 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.3 | 9.7 | PID_INSULIN_PATHWAY | Insulin Pathway |
| 0.4 | 8.0 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 8.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.5 | 7.9 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.3 | 7.5 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 6.7 | PID_P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 127 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 29.6 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.9 | 29.5 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.9 | 26.8 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
| 0.7 | 22.7 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.6 | 19.5 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.8 | 19.3 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.7 | 19.3 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.9 | 17.1 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.7 | 16.9 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 1.0 | 15.5 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.9 | 14.2 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 13.3 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.5 | 12.3 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 3.0 | 12.2 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.9 | 11.7 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.6 | 11.6 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.5 | 11.5 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.5 | 11.4 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.7 | 10.7 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.7 | 10.4 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
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