Motif ID: Tcf7_Tcf7l2

Z-value: 1.777

Transcription factors associated with Tcf7_Tcf7l2:

Gene SymbolEntrez IDGene Name
Tcf7 ENSMUSG00000000782.9 Tcf7
Tcf7l2 ENSMUSG00000024985.12 Tcf7l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l2mm10_v2_chr19_+_55742056_557420660.667.8e-06Click!
Tcf7mm10_v2_chr11_-_52282564_52282579-0.651.2e-05Click!


Activity profile for motif Tcf7_Tcf7l2.

activity profile for motif Tcf7_Tcf7l2


Sorted Z-values histogram for motif Tcf7_Tcf7l2

Sorted Z-values for motif Tcf7_Tcf7l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7_Tcf7l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_152081529 11.282 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr15_+_85859689 10.736 ENSMUST00000170629.1
 Gtse1
G two S phase expressed protein 1
chr2_+_102706356 10.564 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
 Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chr15_+_102296256 10.051 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr10_-_92165159 9.473 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr4_-_43499608 8.549 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr7_+_67655414 7.696 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr2_+_153031852 7.665 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr14_-_52020698 7.348 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chr18_-_62756275 7.347 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr7_+_45216671 7.115 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr10_+_127725392 7.004 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr7_+_27499315 7.001 ENSMUST00000098644.2
ENSMUST00000108355.1
 Prx

periaxin

chr3_+_76074270 6.960 ENSMUST00000038364.8
 Fstl5
follistatin-like 5
chr10_-_92164666 6.948 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr17_-_47016956 6.854 ENSMUST00000165525.1
 Gm16494
predicted gene 16494
chr9_-_96719549 6.104 ENSMUST00000128269.1
 Zbtb38
zinc finger and BTB domain containing 38
chr2_+_20737306 5.864 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr5_-_44102032 5.738 ENSMUST00000171543.1
 Prom1
prominin 1
chr17_-_51810866 5.735 ENSMUST00000176669.1
 Satb1
special AT-rich sequence binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 171 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.4 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 12.4 GO:0006275 regulation of DNA replication(GO:0006275)
1.5 10.6 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.7 10.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.5 9.1 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.4 7.5 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.2 7.5 GO:0001947 heart looping(GO:0001947)
0.3 7.1 GO:0048368 lateral mesoderm development(GO:0048368)
1.8 7.0 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
2.2 6.7 GO:0030421 defecation(GO:0030421)
0.0 6.5 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
2.0 5.9 GO:0061181 regulation of chondrocyte development(GO:0061181)
1.9 5.7 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.3 5.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
1.3 5.4 GO:0006982 response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449)
0.5 5.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 5.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.0 4.9 GO:0051661 maintenance of centrosome location(GO:0051661)
1.6 4.8 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.4 4.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 11.0 GO:0005667 transcription factor complex(GO:0005667)
0.3 10.6 GO:0030673 axolemma(GO:0030673)
0.1 10.4 GO:0072562 blood microparticle(GO:0072562)
0.1 9.6 GO:0072686 mitotic spindle(GO:0072686)
0.1 7.5 GO:0005720 nuclear heterochromatin(GO:0005720)
2.4 7.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 6.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 6.6 GO:0010369 chromocenter(GO:0010369)
0.0 5.8 GO:0005815 microtubule organizing center(GO:0005815)
1.9 5.7 GO:0071914 prominosome(GO:0071914)
0.1 5.1 GO:0000922 spindle pole(GO:0000922)
1.0 4.9 GO:0036449 microtubule minus-end(GO:0036449)
0.1 4.8 GO:0016605 PML body(GO:0016605)
0.5 4.4 GO:0030478 actin cap(GO:0030478)
0.0 4.3 GO:1990204 oxidoreductase complex(GO:1990204)
1.0 4.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.3 4.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.5 4.0 GO:0033269 internode region of axon(GO:0033269)
0.1 4.0 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.2 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 14.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 11.5 GO:0003677 DNA binding(GO:0003677)
1.8 10.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 10.5 GO:0045296 cadherin binding(GO:0045296)
0.1 9.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.4 9.5 GO:0008327 methyl-CpG binding(GO:0008327)
1.2 7.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.3 6.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 6.5 GO:0008201 heparin binding(GO:0008201)
0.0 6.5 GO:0003682 chromatin binding(GO:0003682)
0.3 5.9 GO:0070411 I-SMAD binding(GO:0070411)
0.1 5.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.3 5.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 4.9 GO:0070491 repressing transcription factor binding(GO:0070491)
0.3 4.8 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.5 4.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.3 4.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.2 4.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 4.1 GO:1990782 protein tyrosine kinase binding(GO:1990782)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.5 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 8.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 7.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 7.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 6.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.2 6.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 5.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.0 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 4.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 4.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.3 3.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.5 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 3.2 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.4 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 2.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.9 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.9 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.3 PID_CXCR3_PATHWAY CXCR3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 8.7 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 8.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 6.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 5.7 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 5.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 5.0 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 5.0 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION Genes involved in Extracellular matrix organization
0.1 4.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 4.6 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3 4.5 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 4.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 4.3 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.7 4.1 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 4.1 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 4.0 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 3.7 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 3.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.3 3.1 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 3.0 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins