Motif ID: Tcf7l1

Z-value: 0.881


Transcription factors associated with Tcf7l1:

Gene SymbolEntrez IDGene Name
Tcf7l1 ENSMUSG00000055799.7 Tcf7l1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l1mm10_v2_chr6_-_72788952_727890610.325.3e-02Click!


Activity profile for motif Tcf7l1.

activity profile for motif Tcf7l1


Sorted Z-values histogram for motif Tcf7l1

Sorted Z-values for motif Tcf7l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_108921648 3.450 ENSMUST00000144511.1
 Axin2
axin2
chr11_+_108920800 3.124 ENSMUST00000140821.1
 Axin2
axin2
chr2_+_153031852 3.010 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr2_+_152081529 2.472 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr7_-_115824699 2.345 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr7_+_45216671 2.187 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr3_+_131110350 2.022 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr1_-_183147461 1.743 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr18_-_62756275 1.678 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr9_+_119402444 1.592 ENSMUST00000035093.8
ENSMUST00000165044.1
 Acvr2b

activin receptor IIB

chr18_+_82914632 1.486 ENSMUST00000071233.6
 Zfp516
zinc finger protein 516
chr10_+_80150448 1.481 ENSMUST00000153477.1
 Midn
midnolin
chr7_+_100493795 1.464 ENSMUST00000129324.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr17_-_35697971 1.433 ENSMUST00000146472.1
 Ddr1
discoidin domain receptor family, member 1
chr2_+_124610573 1.361 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr13_-_54687644 1.359 ENSMUST00000129881.1
 Rnf44
ring finger protein 44
chr9_+_35423582 1.312 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr17_+_3326552 1.307 ENSMUST00000169838.1
 Tiam2
T cell lymphoma invasion and metastasis 2
chr8_+_79028587 1.235 ENSMUST00000119254.1
 Zfp827
zinc finger protein 827
chr14_+_27039001 1.225 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 7.4 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.2 4.0 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
0.4 2.6 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 2.5 GO:2001222 regulation of neuron migration(GO:2001222)
0.2 2.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 2.2 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.1 2.2 GO:0048368 lateral mesoderm development(GO:0048368)
0.7 2.0 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.2 1.8 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.2 1.7 GO:0060539 diaphragm development(GO:0060539)
0.1 1.7 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.2 1.5 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 1.5 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 1.5 GO:0009409 response to cold(GO:0009409)
0.1 1.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 1.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 1.3 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2 1.3 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 1.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0005813 centrosome(GO:0005813)
0.1 2.6 GO:0071564 npBAF complex(GO:0071564)
0.7 2.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.2 1.9 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 1.7 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 1.4 GO:0043235 receptor complex(GO:0043235)
0.0 1.4 GO:0030139 endocytic vesicle(GO:0030139)
0.1 1.3 GO:0001739 sex chromatin(GO:0001739)
0.1 1.3 GO:0036038 MKS complex(GO:0036038)
0.1 1.2 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.2 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.2 GO:0000922 spindle pole(GO:0000922)
0.3 1.1 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.3 1.1 GO:0008623 CHRAC(GO:0008623)
0.1 1.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.3 1.0 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.2 0.9 GO:1990032 parallel fiber(GO:1990032)
0.1 0.9 GO:0016342 catenin complex(GO:0016342)
0.1 0.9 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.9 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 7.4 GO:0070411 I-SMAD binding(GO:0070411)
0.0 3.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.3 2.0 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 1.9 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 1.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 1.6 GO:0034711 inhibin binding(GO:0034711)
0.1 1.6 GO:0015197 peptide transporter activity(GO:0015197)
0.0 1.6 GO:0033613 activating transcription factor binding(GO:0033613)
0.4 1.5 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.2 1.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 1.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 1.3 GO:0050436 microfibril binding(GO:0050436)
0.0 1.3 GO:0005112 Notch binding(GO:0005112)
0.4 1.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 1.2 GO:0035198 miRNA binding(GO:0035198)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.0 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 2.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 2.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.1 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.0 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.9 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 0.8 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 2.5 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 1.6 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 1.6 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 1.2 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 1.2 REACTOME_SIGNALING_BY_FGFR Genes involved in Signaling by FGFR
0.1 1.1 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.8 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.8 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 0.7 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.7 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.7 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 0.5 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways