Motif ID: Tead3_Tead4

Z-value: 1.195

Transcription factors associated with Tead3_Tead4:

Gene SymbolEntrez IDGene Name
Tead3 ENSMUSG00000002249.11 Tead3
Tead4 ENSMUSG00000030353.9 Tead4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tead3mm10_v2_chr17_-_28350747_283508200.492.0e-03Click!


Activity profile for motif Tead3_Tead4.

activity profile for motif Tead3_Tead4


Sorted Z-values histogram for motif Tead3_Tead4

Sorted Z-values for motif Tead3_Tead4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tead3_Tead4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_43558386 6.067 ENSMUST00000130353.1
 Tln1
talin 1
chr1_+_43730593 5.930 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr10_+_24595434 5.589 ENSMUST00000020171.5
 Ctgf
connective tissue growth factor
chr10_+_24595623 5.174 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr7_-_132813799 4.922 ENSMUST00000097998.2
 Fam53b
family with sequence similarity 53, member B
chr10_+_28074813 4.470 ENSMUST00000166468.1
 Ptprk
protein tyrosine phosphatase, receptor type, K
chr11_-_100970887 4.355 ENSMUST00000060792.5
 Ptrf
polymerase I and transcript release factor
chr15_+_6386598 3.681 ENSMUST00000080880.5
ENSMUST00000110664.2
ENSMUST00000110663.2
ENSMUST00000161812.1
ENSMUST00000160134.1
 Dab2




disabled 2, mitogen-responsive phosphoprotein




chr6_+_121300227 3.673 ENSMUST00000064580.7
 Slc6a13
solute carrier family 6 (neurotransmitter transporter, GABA), member 13
chr7_-_132813715 3.469 ENSMUST00000134946.1
 Fam53b
family with sequence similarity 53, member B
chr17_-_35702297 2.880 ENSMUST00000135078.1
 Ddr1
discoidin domain receptor family, member 1
chr7_+_51880312 2.698 ENSMUST00000145049.1
 Gas2
growth arrest specific 2
chr11_-_32222233 2.643 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr17_+_78508063 2.585 ENSMUST00000024880.9
 Vit
vitrin
chr10_-_42276688 2.481 ENSMUST00000175881.1
ENSMUST00000056974.3
 Foxo3

forkhead box O3

chr9_+_69454066 2.471 ENSMUST00000134907.1
 Anxa2
annexin A2
chr7_-_19698206 2.361 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr17_+_3397189 2.277 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr17_-_35702040 2.262 ENSMUST00000166980.2
ENSMUST00000145900.1
 Ddr1

discoidin domain receptor family, member 1

chr10_-_42276744 2.222 ENSMUST00000105502.1
ENSMUST00000105501.1
 Foxo3

forkhead box O3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 10.8 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.2 8.3 GO:0035411 catenin import into nucleus(GO:0035411)
0.7 8.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.7 5.9 GO:0070314 G1 to G0 transition(GO:0070314)
0.7 5.8 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.7 4.7 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.4 4.5 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.8 4.2 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
1.2 3.7 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.6 3.7 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.5 3.6 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 3.3 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.5 3.2 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.2 2.5 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.6 2.3 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.2 2.3 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
0.5 2.2 GO:0042360 vitamin E metabolic process(GO:0042360)
0.4 2.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 2.1 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 2.0 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.2 GO:0005667 transcription factor complex(GO:0005667)
0.2 10.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 8.7 GO:0001726 ruffle(GO:0001726)
0.0 7.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.3 4.7 GO:0031045 dense core granule(GO:0031045)
1.4 4.3 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
1.4 4.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
1.2 3.7 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.9 3.7 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 2.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 2.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.4 2.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 2.0 GO:0016235 aggresome(GO:0016235)
0.2 1.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 1.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.6 GO:0010369 chromocenter(GO:0010369)
0.1 1.3 GO:0030478 actin cap(GO:0030478)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 13.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.9 8.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.7 6.1 GO:0030274 LIM domain binding(GO:0030274)
0.1 6.1 GO:0001221 transcription cofactor binding(GO:0001221)
1.0 4.2 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.2 4.2 GO:0045295 gamma-catenin binding(GO:0045295)
1.2 3.7 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.2 3.7 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.3 3.7 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.3 3.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 2.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 2.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 2.3 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 2.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 2.2 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.1 2.1 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 2.0 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 2.0 GO:0030506 ankyrin binding(GO:0030506)
0.0 2.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.6 1.9 GO:0042936 dipeptide transporter activity(GO:0042936)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.5 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 6.2 NABA_COLLAGENS Genes encoding collagen proteins
0.2 5.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.2 3.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 3.7 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 3.6 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.2 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 2.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.1 ST_STAT3_PATHWAY STAT3 Pathway
0.1 2.1 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 2.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 1.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 1.6 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 1.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.6 PID_AP1_PATHWAY AP-1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 17.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 6.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 6.1 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.5 5.9 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 5.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 4.7 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.2 4.4 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 4.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 3.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 3.0 REACTOME_PI3K_AKT_ACTIVATION Genes involved in PI3K/AKT activation
0.2 2.7 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 2.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.4 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 1.3 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 1.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)