Motif ID: Tfap2a

Z-value: 0.946


Transcription factors associated with Tfap2a:

Gene SymbolEntrez IDGene Name
Tfap2a ENSMUSG00000021359.9 Tfap2a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2amm10_v2_chr13_-_40733768_407338360.105.4e-01Click!


Activity profile for motif Tfap2a.

activity profile for motif Tfap2a


Sorted Z-values histogram for motif Tfap2a

Sorted Z-values for motif Tfap2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_100015817 5.159 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr9_+_21184103 4.526 ENSMUST00000115458.2
 Pde4a
phosphodiesterase 4A, cAMP specific
chr15_-_45114926 4.101 ENSMUST00000022967.5
 Kcnv1
potassium channel, subfamily V, member 1
chr12_-_67221221 3.442 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr5_-_146585239 3.248 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr1_+_159737510 3.103 ENSMUST00000111669.3
 Tnr
tenascin R
chr12_-_76822510 2.998 ENSMUST00000021459.7
 Rab15
RAB15, member RAS oncogene family
chr13_-_98206151 2.951 ENSMUST00000109426.1
 Arhgef28
Rho guanine nucleotide exchange factor (GEF) 28
chr10_-_86498836 2.924 ENSMUST00000120638.1
 Syn3
synapsin III
chr17_+_69969073 2.871 ENSMUST00000133983.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr17_+_69969387 2.859 ENSMUST00000146730.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr14_+_68083853 2.687 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr8_+_70493156 2.650 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr17_+_69969217 2.623 ENSMUST00000060072.5
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr17_-_29237759 2.572 ENSMUST00000137727.1
ENSMUST00000024805.7
 Cpne5

copine V

chr9_+_109931774 2.547 ENSMUST00000169851.2
 Map4
microtubule-associated protein 4
chr9_+_26733728 2.530 ENSMUST00000160899.1
ENSMUST00000161431.1
ENSMUST00000159799.1
 B3gat1


beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)


chrX_-_162643575 2.402 ENSMUST00000101102.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr10_+_86021961 2.385 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr2_-_163918683 2.383 ENSMUST00000044734.2
 Rims4
regulating synaptic membrane exocytosis 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 218 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.4 GO:0070842 aggresome assembly(GO:0070842)
0.2 6.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.3 6.3 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
1.3 5.2 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.5 3.8 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 3.5 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.1 3.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.3 3.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.8 3.1 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.2 3.0 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 2.9 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.1 2.8 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.9 2.7 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.4 2.6 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 2.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.5 2.5 GO:0051012 microtubule sliding(GO:0051012)
0.6 2.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 2.4 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.1 2.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 2.3 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.8 GO:0014069 postsynaptic density(GO:0014069)
0.0 4.9 GO:0030175 filopodium(GO:0030175)
0.0 4.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.3 GO:0000139 Golgi membrane(GO:0000139)
0.2 4.0 GO:0043196 varicosity(GO:0043196)
0.0 3.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 3.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 3.2 GO:0048786 presynaptic active zone(GO:0048786)
0.1 3.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.0 3.1 GO:0072534 perineuronal net(GO:0072534)
0.1 3.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.9 2.7 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.9 2.6 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 2.6 GO:0016459 myosin complex(GO:0016459)
0.5 2.4 GO:1990037 Lewy body core(GO:1990037)
0.0 2.3 GO:0008021 synaptic vesicle(GO:0008021)
0.1 2.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.4 1.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.7 GO:0031045 dense core granule(GO:0031045)
0.1 1.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.3 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.2 6.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.9 5.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 4.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 4.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 4.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 4.2 GO:0003924 GTPase activity(GO:0003924)
0.5 3.8 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.2 3.5 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 3.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 3.3 GO:0046625 sphingolipid binding(GO:0046625)
0.0 2.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.7 GO:0043274 phospholipase binding(GO:0043274)
0.4 2.6 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.5 2.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 2.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 2.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 2.3 GO:0044325 ion channel binding(GO:0044325)
0.1 2.2 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 2.2 GO:0043130 ubiquitin binding(GO:0043130)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 4.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 4.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 3.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.5 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 2.5 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 1.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.9 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.9 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 0.8 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.7 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.3 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.3 4.8 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.2 4.8 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 4.8 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 3.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 2.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 2.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.1 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.7 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.4 REACTOME_IL_2_SIGNALING Genes involved in Interleukin-2 signaling
0.0 1.3 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.2 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.0 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.1 1.0 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 1.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP