Motif ID: Tfap2b

Z-value: 0.827


Transcription factors associated with Tfap2b:

Gene SymbolEntrez IDGene Name
Tfap2b ENSMUSG00000025927.7 Tfap2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2bmm10_v2_chr1_+_19212054_19212106-0.563.5e-04Click!


Activity profile for motif Tfap2b.

activity profile for motif Tfap2b


Sorted Z-values histogram for motif Tfap2b

Sorted Z-values for motif Tfap2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_5740885 5.817 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr2_+_91945703 5.182 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr12_+_70825492 4.027 ENSMUST00000057859.7
 Frmd6
FERM domain containing 6
chr4_+_48045144 3.081 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr18_+_64340225 3.024 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr1_-_14310198 3.010 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr2_+_153031852 2.271 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr17_+_83215271 2.258 ENSMUST00000170794.1
 Pkdcc
protein kinase domain containing, cytoplasmic
chr13_+_49187485 2.133 ENSMUST00000049022.8
ENSMUST00000120733.1
 Ninj1

ninjurin 1

chr12_+_84009481 2.049 ENSMUST00000168120.1
 Acot1
acyl-CoA thioesterase 1
chr17_+_86963279 1.994 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr11_+_35121126 1.950 ENSMUST00000069837.3
 Slit3
slit homolog 3 (Drosophila)
chr1_-_98095596 1.834 ENSMUST00000058762.8
ENSMUST00000097625.3
 Pam

peptidylglycine alpha-amidating monooxygenase

chr7_+_27607997 1.801 ENSMUST00000142365.1
 Akt2
thymoma viral proto-oncogene 2
chr9_-_40455670 1.682 ENSMUST00000165104.1
ENSMUST00000045682.5
 Gramd1b

GRAM domain containing 1B

chr8_+_84723003 1.646 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr4_+_8690399 1.641 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr4_-_22488296 1.617 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2
chr7_+_27607748 1.597 ENSMUST00000136962.1
 Akt2
thymoma viral proto-oncogene 2
chr2_+_59612034 1.523 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 5.8 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.7 4.7 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.7 4.0 GO:0003383 apical constriction(GO:0003383)
0.2 3.7 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.6 3.4 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
1.0 3.1 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 3.1 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.3 3.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 2.9 GO:0007520 myoblast fusion(GO:0007520)
0.2 2.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 2.4 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.4 2.3 GO:0090005 negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 2.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 2.0 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.2 1.9 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.4 1.8 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 1.8 GO:0009404 toxin metabolic process(GO:0009404)
0.2 1.7 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.2 1.7 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 1.6 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.6 GO:0043296 apical junction complex(GO:0043296)
0.0 4.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.7 GO:0032993 protein-DNA complex(GO:0032993)
0.2 3.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 2.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 2.2 GO:0001726 ruffle(GO:0001726)
0.0 1.9 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.8 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.4 GO:0032433 filopodium tip(GO:0032433)
0.1 1.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 1.0 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)
0.2 0.8 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.7 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 0.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.6 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.5 GO:0090543 Flemming body(GO:0090543)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 4.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 3.1 GO:0005522 profilin binding(GO:0005522)
0.1 3.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 3.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.8 GO:0005080 protein kinase C binding(GO:0005080)
0.0 2.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 2.0 GO:0048495 Roundabout binding(GO:0048495)
0.1 2.0 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 1.9 GO:0017124 SH3 domain binding(GO:0017124)
0.6 1.8 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 1.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.8 GO:0070412 R-SMAD binding(GO:0070412)
0.1 1.6 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.6 GO:0051082 unfolded protein binding(GO:0051082)
0.3 1.4 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.2 1.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.3 1.3 GO:0005095 GTPase inhibitor activity(GO:0005095)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 6.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 3.0 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 2.1 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.3 PID_EPO_PATHWAY EPO signaling pathway
0.0 1.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.9 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 0.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.8 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.5 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.3 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.3 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.4 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 3.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.4 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.7 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 1.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.2 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 1.2 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.0 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 0.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.5 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.5 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.4 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway