Motif ID: Tfap2c

Z-value: 1.025


Transcription factors associated with Tfap2c:

Gene SymbolEntrez IDGene Name
Tfap2c ENSMUSG00000028640.5 Tfap2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2cmm10_v2_chr2_+_172550761_172550782-0.633.4e-05Click!


Activity profile for motif Tfap2c.

activity profile for motif Tfap2c


Sorted Z-values histogram for motif Tfap2c

Sorted Z-values for motif Tfap2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_70493156 7.291 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr14_+_119138415 6.692 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr6_+_4505493 5.243 ENSMUST00000031668.8
 Col1a2
collagen, type I, alpha 2
chr11_-_106715251 3.612 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
 Pecam1



platelet/endothelial cell adhesion molecule 1



chr16_+_91225550 3.533 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr9_-_29411736 3.457 ENSMUST00000115236.1
 Ntm
neurotrimin
chr9_-_29412204 3.454 ENSMUST00000115237.1
 Ntm
neurotrimin
chr7_-_4789541 3.172 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr4_+_152338887 3.098 ENSMUST00000005175.4
 Chd5
chromodomain helicase DNA binding protein 5
chr15_+_76457438 3.027 ENSMUST00000043089.7
 Scx
scleraxis
chr12_-_76709997 2.949 ENSMUST00000166101.1
 Sptb
spectrin beta, erythrocytic
chr6_+_4504814 2.913 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr4_+_152338619 2.839 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr6_+_38663061 2.663 ENSMUST00000114874.3
 Clec2l
C-type lectin domain family 2, member L
chr4_+_104367549 2.631 ENSMUST00000106830.2
 Dab1
disabled 1
chr2_+_76406529 2.595 ENSMUST00000111929.1
ENSMUST00000077972.4
ENSMUST00000111930.2
 Osbpl6


oxysterol binding protein-like 6


chr5_-_35679416 2.530 ENSMUST00000114233.2
 Htra3
HtrA serine peptidase 3
chr18_-_61911783 2.525 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr7_-_31126945 2.479 ENSMUST00000098548.4
 Scn1b
sodium channel, voltage-gated, type I, beta
chr1_-_184883218 2.468 ENSMUST00000048308.5
 C130074G19Rik
RIKEN cDNA C130074G19 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.3 GO:0043589 skin morphogenesis(GO:0043589)
1.2 7.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
1.1 6.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 6.4 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.8 5.9 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.9 3.6 GO:0050904 diapedesis(GO:0050904)
1.2 3.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.7 3.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.1 3.2 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
1.0 3.0 GO:0061056 sclerotome development(GO:0061056)
0.1 2.9 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.7 2.6 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812) lateral motor column neuron migration(GO:0097477)
0.8 2.5 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.3 2.5 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 2.5 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 2.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.4 2.2 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 2.2 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.2 2.1 GO:0032482 Rab protein signal transduction(GO:0032482)
0.2 2.1 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.3 GO:0031225 anchored component of membrane(GO:0031225)
2.7 8.2 GO:0005584 collagen type I trimer(GO:0005584)
2.4 7.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.2 5.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 3.8 GO:0005903 brush border(GO:0005903)
0.7 3.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.5 3.4 GO:0005638 lamin filament(GO:0005638)
0.5 2.9 GO:0008091 spectrin(GO:0008091)
0.1 2.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2 2.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 2.5 GO:0030027 lamellipodium(GO:0030027)
0.0 2.2 GO:0043197 dendritic spine(GO:0043197)
0.2 2.1 GO:0032426 stereocilium tip(GO:0032426)
0.1 2.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.1 GO:0044295 axonal growth cone(GO:0044295)
0.1 2.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.9 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 1.7 GO:1902711 GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.0 7.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
1.7 6.7 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
1.5 5.9 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.0 5.9 GO:0003779 actin binding(GO:0003779)
0.0 5.0 GO:0030246 carbohydrate binding(GO:0030246)
0.1 4.5 GO:0071837 HMG box domain binding(GO:0071837)
0.1 3.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 3.3 GO:0070888 E-box binding(GO:0070888)
0.4 3.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 2.9 GO:0030506 ankyrin binding(GO:0030506)
0.0 2.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 2.6 GO:0042169 SH2 domain binding(GO:0042169)
0.0 2.6 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.4 2.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 2.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 2.3 GO:0005179 hormone activity(GO:0005179)
0.3 2.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 2.1 GO:0030507 spectrin binding(GO:0030507)
0.0 2.1 GO:0004713 protein tyrosine kinase activity(GO:0004713)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.9 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 8.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 5.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.7 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.1 3.3 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 2.9 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 2.6 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 2.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 2.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.0 PID_ALK1_PATHWAY ALK1 signaling events
0.1 1.9 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 1.6 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.6 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.8 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.8 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.1 0.7 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.3 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 6.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 5.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 5.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 3.6 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.3 3.2 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 3.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 2.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.0 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 1.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.6 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.6 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 1.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.1 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 1.1 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism