Motif ID: Tfap2d

Z-value: 0.719


Transcription factors associated with Tfap2d:

Gene SymbolEntrez IDGene Name
Tfap2d ENSMUSG00000042596.7 Tfap2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2dmm10_v2_chr1_+_19103022_191030430.651.4e-05Click!


Activity profile for motif Tfap2d.

activity profile for motif Tfap2d


Sorted Z-values histogram for motif Tfap2d

Sorted Z-values for motif Tfap2d



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2d

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_84009481 4.340 ENSMUST00000168120.1
 Acot1
acyl-CoA thioesterase 1
chr11_-_32222233 4.160 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr8_-_105637350 2.587 ENSMUST00000182863.1
 Gm5914
predicted gene 5914
chr12_+_83987854 2.366 ENSMUST00000021649.7
 Acot2
acyl-CoA thioesterase 2
chr7_+_130936172 2.334 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr11_+_74619594 2.291 ENSMUST00000100866.2
 E130309D14Rik
RIKEN cDNA E130309D14 gene
chr9_-_79718631 2.262 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr13_-_101768154 2.220 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr4_-_154636831 2.178 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr5_-_71095765 2.153 ENSMUST00000000572.5
 Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
chr18_+_64340225 2.131 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr6_+_72355425 2.099 ENSMUST00000069695.2
ENSMUST00000132243.1
 Tmem150a

transmembrane protein 150A

chr7_-_4789541 2.098 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr5_+_129584169 2.047 ENSMUST00000031390.8
 Mmp17
matrix metallopeptidase 17
chr9_-_79718518 2.021 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr13_-_92131494 2.016 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr2_+_26586607 1.967 ENSMUST00000174211.1
ENSMUST00000145575.2
ENSMUST00000173920.1
 Egfl7


EGF-like domain 7


chr9_-_79718720 1.856 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1
chr2_-_173276144 1.763 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr8_-_11008458 1.603 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.2 4.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 4.3 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.5 3.2 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.5 2.7 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 2.6 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.3 2.4 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 2.3 GO:0006414 translational elongation(GO:0006414)
0.3 2.2 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.2 2.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 2.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 2.1 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.5 2.0 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.2 2.0 GO:0042756 drinking behavior(GO:0042756)
0.3 1.6 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.2 1.6 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 1.6 GO:0001919 regulation of receptor recycling(GO:0001919)
0.2 1.4 GO:0001542 ovulation from ovarian follicle(GO:0001542) positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.2 1.4 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 1.4 GO:0055003 cardiac myofibril assembly(GO:0055003)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 6.1 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 5.0 GO:0031901 early endosome membrane(GO:0031901)
0.0 4.6 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 2.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 2.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 2.2 GO:0016235 aggresome(GO:0016235)
0.1 2.1 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.8 GO:0031225 anchored component of membrane(GO:0031225)
0.3 1.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.2 1.6 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)
0.2 1.2 GO:0005827 polar microtubule(GO:0005827)
0.1 1.2 GO:0046930 pore complex(GO:0046930)
0.1 1.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 1.1 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.0 GO:0035869 ciliary transition zone(GO:0035869)
0.0 1.0 GO:0030027 lamellipodium(GO:0030027)
0.2 0.7 GO:0036488 CHOP-C/EBP complex(GO:0036488)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 4.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 2.7 GO:0050699 WW domain binding(GO:0050699)
0.0 2.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.5 GO:0005112 Notch binding(GO:0005112)
0.1 2.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 2.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.3 GO:0046332 SMAD binding(GO:0046332)
0.6 2.2 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.4 2.2 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 2.2 GO:0020037 heme binding(GO:0020037)
0.7 2.1 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.3 2.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.5 2.0 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 2.0 GO:0043495 protein anchor(GO:0043495)
0.1 2.0 GO:0070840 dynein complex binding(GO:0070840)
0.1 1.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.7 GO:0047372 acylglycerol lipase activity(GO:0047372)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 3.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 2.1 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 1.9 PID_IGF1_PATHWAY IGF1 pathway
0.1 1.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.4 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 1.3 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 1.2 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.2 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.1 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 1.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 0.9 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.8 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 0.5 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 3.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 3.3 REACTOME_PI3K_AKT_ACTIVATION Genes involved in PI3K/AKT activation
0.2 2.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 2.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.1 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.0 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.2 1.7 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 1.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.3 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.2 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.0 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 0.7 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 0.6 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.6 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis