Motif ID: Tfap2e
Z-value: 0.722
Transcription factors associated with Tfap2e:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Tfap2e | ENSMUSG00000042477.7 | Tfap2e |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Tfap2e | mm10_v2_chr4_-_126736236_126736245 | -0.18 | 3.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 11.5 | GO:0010624 | regulation of Schwann cell proliferation(GO:0010624) |
0.8 | 2.3 | GO:0097212 | lysosomal membrane organization(GO:0097212) |
0.7 | 2.1 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
0.5 | 2.1 | GO:0072531 | pyrimidine-containing compound transmembrane transport(GO:0072531) |
0.4 | 2.4 | GO:0042045 | epithelial fluid transport(GO:0042045) |
0.4 | 3.9 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
0.3 | 1.0 | GO:0071579 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) regulation of zinc ion transport(GO:0071579) |
0.3 | 0.8 | GO:0014877 | response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
0.2 | 0.5 | GO:0086047 | membrane depolarization during Purkinje myocyte cell action potential(GO:0086047) |
0.2 | 1.3 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
0.2 | 0.8 | GO:0097168 | condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168) |
0.2 | 1.3 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
0.2 | 1.2 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
0.1 | 1.0 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
0.1 | 0.9 | GO:0089700 | protein kinase D signaling(GO:0089700) |
0.1 | 1.5 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
0.1 | 1.0 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) regulation of wound healing, spreading of epidermal cells(GO:1903689) |
0.1 | 0.3 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) |
0.1 | 0.8 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
0.1 | 1.3 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
0.1 | 0.3 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
0.1 | 0.5 | GO:0032811 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811) |
0.1 | 0.4 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
0.1 | 0.3 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
0.1 | 0.3 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
0.1 | 1.2 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
0.0 | 0.1 | GO:0090188 | negative regulation of pancreatic juice secretion(GO:0090188) |
0.0 | 0.2 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
0.0 | 0.3 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
0.0 | 0.2 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
0.0 | 0.2 | GO:1900095 | regulation of dosage compensation by inactivation of X chromosome(GO:1900095) |
0.0 | 0.6 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
0.0 | 1.1 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
0.0 | 0.2 | GO:1990403 | embryonic brain development(GO:1990403) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.9 | 11.5 | GO:0097450 | astrocyte end-foot(GO:0097450) |
0.8 | 2.4 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
0.2 | 1.3 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
0.1 | 2.5 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
0.1 | 1.5 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
0.1 | 0.5 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
0.1 | 0.3 | GO:0072534 | perineuronal net(GO:0072534) |
0.1 | 2.1 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
0.1 | 1.3 | GO:0000242 | pericentriolar material(GO:0000242) |
0.0 | 1.4 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
0.0 | 0.3 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
0.0 | 1.3 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
0.0 | 1.0 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 0.5 | GO:0034706 | sodium channel complex(GO:0034706) |
0.0 | 0.1 | GO:0005940 | septin ring(GO:0005940) |
0.0 | 0.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.0 | 2.4 | GO:0043204 | perikaryon(GO:0043204) |
0.0 | 0.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
0.0 | 0.8 | GO:0005776 | autophagosome(GO:0005776) |
0.0 | 0.2 | GO:0030127 | COPII vesicle coat(GO:0030127) |
0.0 | 2.3 | GO:0008021 | synaptic vesicle(GO:0008021) |
0.0 | 0.4 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.0 | 0.3 | GO:0032589 | neuron projection membrane(GO:0032589) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 2.4 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
0.4 | 2.1 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
0.4 | 1.5 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
0.3 | 0.8 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
0.2 | 1.0 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.1 | 11.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.1 | 1.4 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
0.1 | 2.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.1 | 1.0 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
0.1 | 0.5 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
0.1 | 2.1 | GO:0015215 | nucleotide transmembrane transporter activity(GO:0015215) |
0.1 | 2.8 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
0.1 | 1.2 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.0 | 0.3 | GO:0097016 | L27 domain binding(GO:0097016) |
0.0 | 0.3 | GO:0005042 | netrin receptor activity(GO:0005042) |
0.0 | 0.9 | GO:0004697 | protein kinase C activity(GO:0004697) |
0.0 | 0.1 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
0.0 | 0.3 | GO:0004622 | lysophospholipase activity(GO:0004622) acylglycerol lipase activity(GO:0047372) |
0.0 | 0.1 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
0.0 | 0.3 | GO:0046625 | sphingolipid binding(GO:0046625) |
0.0 | 0.5 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
0.0 | 0.2 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
0.0 | 0.4 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
0.0 | 1.0 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 3.6 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
0.1 | 1.5 | PID_IL5_PATHWAY | IL5-mediated signaling events |
0.1 | 1.2 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
0.0 | 1.3 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
0.0 | 1.1 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
0.0 | 0.8 | PID_FOXO_PATHWAY | FoxO family signaling |
0.0 | 1.0 | PID_AVB3_INTEGRIN_PATHWAY | Integrins in angiogenesis |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 11.5 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
0.2 | 1.5 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
0.1 | 2.1 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
0.1 | 1.0 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
0.1 | 1.2 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
0.0 | 0.5 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
0.0 | 2.4 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.0 | 0.3 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
0.0 | 1.5 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
0.0 | 1.0 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.0 | 1.3 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
0.0 | 0.1 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |