Motif ID: Tfcp2

Z-value: 1.686


Transcription factors associated with Tfcp2:

Gene SymbolEntrez IDGene Name
Tfcp2 ENSMUSG00000009733.8 Tfcp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfcp2mm10_v2_chr15_-_100551959_1005520100.581.5e-04Click!


Activity profile for motif Tfcp2.

activity profile for motif Tfcp2


Sorted Z-values histogram for motif Tfcp2

Sorted Z-values for motif Tfcp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfcp2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_57511833 18.373 ENSMUST00000067925.6
Hmgb2
high mobility group box 2
chr11_+_69045640 11.859 ENSMUST00000108666.1
ENSMUST00000021277.5
Aurkb

aurora kinase B

chr11_-_22001605 10.153 ENSMUST00000006071.7
Otx1
orthodenticle homolog 1 (Drosophila)
chr6_+_56017489 9.897 ENSMUST00000052827.4
Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr13_-_100786402 9.446 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
Ccnb1


cyclin B1


chr4_-_132422394 8.439 ENSMUST00000152271.1
ENSMUST00000084170.5
Phactr4

phosphatase and actin regulator 4

chr16_-_26989974 7.801 ENSMUST00000089832.4
Gmnc
geminin coiled-coil domain containing
chr14_-_21989475 7.713 ENSMUST00000043409.7
Zfp503
zinc finger protein 503
chr5_+_92809372 7.681 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr9_-_96862903 7.316 ENSMUST00000121077.1
ENSMUST00000124923.1
Acpl2

acid phosphatase-like 2

chr1_+_107511489 7.248 ENSMUST00000064916.2
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr2_-_5012716 7.192 ENSMUST00000027980.7
Mcm10
minichromosome maintenance deficient 10 (S. cerevisiae)
chr12_+_24708984 7.135 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr14_+_13284774 7.116 ENSMUST00000070323.5
Synpr
synaptoporin
chr1_+_107511416 7.053 ENSMUST00000009356.4
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr11_-_84067063 6.636 ENSMUST00000108101.1
Dusp14
dual specificity phosphatase 14
chr1_+_61638819 6.599 ENSMUST00000138768.1
ENSMUST00000075374.3
Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr2_-_102186322 6.388 ENSMUST00000111222.1
ENSMUST00000058790.5
Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr1_-_131097535 6.327 ENSMUST00000016672.4
Mapkapk2
MAP kinase-activated protein kinase 2
chr6_+_14901344 6.232 ENSMUST00000115477.1
Foxp2
forkhead box P2
chr5_+_33658550 5.575 ENSMUST00000152847.1
Tacc3
transforming, acidic coiled-coil containing protein 3
chr10_-_42583628 5.542 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr6_+_134929089 5.451 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
RP23-45G16.5


RP23-45G16.5


chr1_+_184034381 5.334 ENSMUST00000048655.7
Dusp10
dual specificity phosphatase 10
chr5_+_33658567 5.297 ENSMUST00000114426.3
Tacc3
transforming, acidic coiled-coil containing protein 3
chr18_+_11633276 5.245 ENSMUST00000115861.2
Rbbp8
retinoblastoma binding protein 8
chr16_-_96127604 5.212 ENSMUST00000133885.1
ENSMUST00000050884.7
Hmgn1

high mobility group nucleosomal binding domain 1

chr16_-_50432340 5.050 ENSMUST00000066037.6
ENSMUST00000089399.4
ENSMUST00000089404.3
ENSMUST00000114477.1
ENSMUST00000138166.1
Bbx




bobby sox homolog (Drosophila)




chr11_-_100939357 4.915 ENSMUST00000092671.5
ENSMUST00000103114.1
Stat3

signal transducer and activator of transcription 3

chr6_+_134929118 4.875 ENSMUST00000185152.1
ENSMUST00000184504.1
RP23-45G16.5

RP23-45G16.5

chr11_-_100939540 4.801 ENSMUST00000127638.1
Stat3
signal transducer and activator of transcription 3
chr14_-_34374617 4.752 ENSMUST00000023826.4
Sncg
synuclein, gamma
chr11_-_100939457 4.603 ENSMUST00000138438.1
Stat3
signal transducer and activator of transcription 3
chr4_-_133967893 4.396 ENSMUST00000100472.3
ENSMUST00000136327.1
Hmgn2

high mobility group nucleosomal binding domain 2

chr6_-_39557830 4.231 ENSMUST00000036877.3
ENSMUST00000154149.1
Dennd2a

DENN/MADD domain containing 2A

chr4_-_133967953 4.145 ENSMUST00000102553.4
Hmgn2
high mobility group nucleosomal binding domain 2
chr15_-_85578070 4.139 ENSMUST00000109424.2
Wnt7b
wingless-related MMTV integration site 7B
chr16_+_38902305 3.974 ENSMUST00000023478.7
Igsf11
immunoglobulin superfamily, member 11
chr17_+_34593388 3.902 ENSMUST00000174532.1
Pbx2
pre B cell leukemia homeobox 2
chr1_+_82316452 3.866 ENSMUST00000027322.7
Rhbdd1
rhomboid domain containing 1
chr6_+_127887582 3.749 ENSMUST00000032501.4
Tspan11
tetraspanin 11
chr14_-_73325773 3.721 ENSMUST00000022701.6
Rb1
retinoblastoma 1
chr12_-_91779129 3.508 ENSMUST00000170077.1
Ston2
stonin 2
chr11_+_50376982 3.414 ENSMUST00000109142.1
Hnrnph1
heterogeneous nuclear ribonucleoprotein H1
chr17_-_25727364 3.156 ENSMUST00000170070.1
ENSMUST00000048054.7
Chtf18

CTF18, chromosome transmission fidelity factor 18

chr1_+_44551483 3.098 ENSMUST00000074525.3
Gulp1
GULP, engulfment adaptor PTB domain containing 1
chrX_+_73639414 3.086 ENSMUST00000019701.8
Dusp9
dual specificity phosphatase 9
chr4_-_132422484 3.048 ENSMUST00000102568.3
Phactr4
phosphatase and actin regulator 4
chr14_+_56887795 3.044 ENSMUST00000022511.8
Zmym2
zinc finger, MYM-type 2
chr16_-_16527364 3.014 ENSMUST00000069284.7
Fgd4
FYVE, RhoGEF and PH domain containing 4
chr18_+_60925644 2.966 ENSMUST00000115297.1
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr5_-_125042794 2.959 ENSMUST00000125053.1
Ncor2
nuclear receptor co-repressor 2
chr13_+_33964659 2.938 ENSMUST00000021843.5
ENSMUST00000058978.7
Nqo2

NAD(P)H dehydrogenase, quinone 2

chrX_-_102250940 2.773 ENSMUST00000134887.1
Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr2_+_84798828 2.730 ENSMUST00000102642.2
ENSMUST00000150325.1
Ube2l6

ubiquitin-conjugating enzyme E2L 6

chr17_+_36837123 2.726 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
Trim26





tripartite motif-containing 26





chr6_+_5390387 2.692 ENSMUST00000183358.1
Asb4
ankyrin repeat and SOCS box-containing 4
chr10_+_69212634 2.683 ENSMUST00000020101.5
Rhobtb1
Rho-related BTB domain containing 1
chrX_+_36795642 2.674 ENSMUST00000016463.3
Slc25a5
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
chr3_+_41742615 2.674 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr2_+_163225363 2.664 ENSMUST00000099110.3
ENSMUST00000165937.1
Tox2

TOX high mobility group box family member 2

chr18_-_24020749 2.525 ENSMUST00000066497.5
Zfp191
zinc finger protein 191
chr5_+_124629050 2.516 ENSMUST00000037865.8
Atp6v0a2
ATPase, H+ transporting, lysosomal V0 subunit A2
chr5_+_114786045 2.470 ENSMUST00000137519.1
Ankrd13a
ankyrin repeat domain 13a
chr16_-_20610741 2.430 ENSMUST00000045918.8
Alg3
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr1_-_161251153 2.430 ENSMUST00000051925.4
ENSMUST00000071718.5
Prdx6

peroxiredoxin 6

chr5_-_100500592 2.391 ENSMUST00000149714.1
ENSMUST00000046154.5
Lin54

lin-54 homolog (C. elegans)

chr7_+_127471484 2.315 ENSMUST00000033095.8
Prr14
proline rich 14
chr4_-_153482768 2.285 ENSMUST00000105646.2
Ajap1
adherens junction associated protein 1
chr5_-_30073554 2.168 ENSMUST00000026846.6
Tyms
thymidylate synthase
chr18_+_65582281 2.150 ENSMUST00000183319.1
Zfp532
zinc finger protein 532
chr4_-_154025926 2.092 ENSMUST00000132541.1
ENSMUST00000143047.1
Smim1

small integral membrane protein 1

chr2_+_93187574 2.059 ENSMUST00000090554.4
Trp53i11
transformation related protein 53 inducible protein 11
chr5_-_8997324 2.050 ENSMUST00000003720.4
Crot
carnitine O-octanoyltransferase
chr2_+_83724397 2.032 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
Itgav


integrin alpha V


chr7_+_101969796 2.025 ENSMUST00000084852.5
Numa1
nuclear mitotic apparatus protein 1
chr4_-_21685782 2.010 ENSMUST00000076206.4
Prdm13
PR domain containing 13
chr4_-_154025867 1.997 ENSMUST00000130175.1
ENSMUST00000182151.1
Smim1

small integral membrane protein 1

chr12_+_17266545 1.986 ENSMUST00000057288.5
Pdia6
protein disulfide isomerase associated 6
chr18_+_60925612 1.984 ENSMUST00000102888.3
ENSMUST00000025519.4
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr6_-_21852509 1.961 ENSMUST00000031678.3
Tspan12
tetraspanin 12
chr7_+_136894598 1.926 ENSMUST00000081510.2
Mgmt
O-6-methylguanine-DNA methyltransferase
chr19_-_12765447 1.920 ENSMUST00000112933.1
Cntf
ciliary neurotrophic factor
chr2_+_32535724 1.894 ENSMUST00000133366.1
Fam102a
family with sequence similarity 102, member A
chr17_+_35059035 1.863 ENSMUST00000007255.6
ENSMUST00000174493.1
Ddah2

dimethylarginine dimethylaminohydrolase 2

chr11_+_98937669 1.844 ENSMUST00000107475.2
ENSMUST00000068133.3
Rara

retinoic acid receptor, alpha

chr4_-_154025616 1.834 ENSMUST00000182191.1
ENSMUST00000146543.2
Smim1

small integral membrane protein 1

chr10_+_69212676 1.822 ENSMUST00000167384.1
Rhobtb1
Rho-related BTB domain containing 1
chr14_-_59395381 1.815 ENSMUST00000166912.2
Phf11c
PHD finger protein 11C
chrX_-_10216437 1.805 ENSMUST00000115534.1
Rpgr
retinitis pigmentosa GTPase regulator
chr11_+_3289880 1.794 ENSMUST00000110043.1
ENSMUST00000094471.3
Patz1

POZ (BTB) and AT hook containing zinc finger 1

chr7_+_127471009 1.755 ENSMUST00000133938.1
Prr14
proline rich 14
chr6_+_14901440 1.749 ENSMUST00000128567.1
Foxp2
forkhead box P2
chr12_-_75177325 1.749 ENSMUST00000042299.2
Kcnh5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr8_+_120488416 1.699 ENSMUST00000034279.9
Gse1
genetic suppressor element 1
chr5_-_142905816 1.695 ENSMUST00000171419.1
Actb
actin, beta
chr5_-_142906702 1.688 ENSMUST00000167721.1
ENSMUST00000163829.1
ENSMUST00000100497.4
Actb


actin, beta


chr17_+_4994904 1.676 ENSMUST00000092723.4
ENSMUST00000115797.2
Arid1b

AT rich interactive domain 1B (SWI-like)

chr5_-_142905928 1.663 ENSMUST00000106216.2
Actb
actin, beta
chr14_+_79481164 1.626 ENSMUST00000040131.5
Elf1
E74-like factor 1
chr5_-_33657889 1.590 ENSMUST00000019439.7
Tmem129
transmembrane protein 129
chr7_-_7209998 1.531 ENSMUST00000074455.7
Zfp772
zinc finger protein 772
chr16_+_37868383 1.489 ENSMUST00000078717.6
Lrrc58
leucine rich repeat containing 58
chr7_+_63444741 1.466 ENSMUST00000058476.7
Otud7a
OTU domain containing 7A
chrX_+_52912232 1.460 ENSMUST00000078944.6
ENSMUST00000101587.3
ENSMUST00000154864.2
Phf6


PHD finger protein 6


chr7_-_25658726 1.444 ENSMUST00000071329.6
Bckdha
branched chain ketoacid dehydrogenase E1, alpha polypeptide
chr11_+_23256001 1.436 ENSMUST00000020538.6
ENSMUST00000109551.1
ENSMUST00000102870.1
ENSMUST00000102869.1
Xpo1



exportin 1, CRM1 homolog (yeast)



chr3_+_122729158 1.423 ENSMUST00000066728.5
Pde5a
phosphodiesterase 5A, cGMP-specific
chrX_-_75130914 1.387 ENSMUST00000114091.1
Mpp1
membrane protein, palmitoylated
chr4_+_109676568 1.371 ENSMUST00000102724.4
Faf1
Fas-associated factor 1
chrX_+_152233228 1.371 ENSMUST00000112588.2
ENSMUST00000082177.6
Kdm5c

lysine (K)-specific demethylase 5C

chr17_-_56005566 1.322 ENSMUST00000043785.6
Stap2
signal transducing adaptor family member 2
chr18_+_65582239 1.287 ENSMUST00000182684.1
Zfp532
zinc finger protein 532
chr1_+_160906372 1.277 ENSMUST00000161609.1
Rc3h1
RING CCCH (C3H) domains 1
chrX_-_75130996 1.234 ENSMUST00000033775.2
Mpp1
membrane protein, palmitoylated
chr3_+_146450467 1.219 ENSMUST00000061937.6
ENSMUST00000029840.3
Ctbs

chitobiase, di-N-acetyl-

chr1_+_55052770 1.218 ENSMUST00000027125.5
ENSMUST00000087617.4
Coq10b

coenzyme Q10 homolog B (S. cerevisiae)

chr14_-_79481268 1.217 ENSMUST00000022601.5
Wbp4
WW domain binding protein 4
chr16_+_20673517 1.216 ENSMUST00000115460.1
Eif4g1
eukaryotic translation initiation factor 4, gamma 1
chr9_+_35423582 1.216 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr15_-_73184840 1.212 ENSMUST00000044113.10
Ago2
argonaute RISC catalytic subunit 2
chr4_+_133584355 1.204 ENSMUST00000030661.7
Gpn2
GPN-loop GTPase 2
chr19_-_28963863 1.177 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr11_+_75532127 1.173 ENSMUST00000127226.1
Slc43a2
solute carrier family 43, member 2
chr19_-_60861390 1.160 ENSMUST00000135808.1
Sfxn4
sideroflexin 4
chr4_+_95579463 1.151 ENSMUST00000150830.1
ENSMUST00000134012.2
Fggy

FGGY carbohydrate kinase domain containing

chr4_+_133584419 1.138 ENSMUST00000105899.1
Gpn2
GPN-loop GTPase 2
chr5_-_129787175 1.123 ENSMUST00000031399.6
Psph
phosphoserine phosphatase
chr14_+_30479565 1.123 ENSMUST00000022535.7
Dcp1a
DCP1 decapping enzyme homolog A (S. cerevisiae)
chr7_+_30095150 1.119 ENSMUST00000130526.1
ENSMUST00000108200.1
Zfp260

zinc finger protein 260

chrX_+_74254736 1.075 ENSMUST00000096424.4
Emd
emerin
chr19_+_6909692 1.064 ENSMUST00000088257.7
Trmt112
tRNA methyltransferase 11-2
chr17_+_7170101 1.060 ENSMUST00000024575.6
Rps6ka2
ribosomal protein S6 kinase, polypeptide 2
chr16_+_20611585 1.054 ENSMUST00000115522.2
ENSMUST00000119224.1
ENSMUST00000079600.4
ENSMUST00000120394.1
Ece2



endothelin converting enzyme 2



chrX_+_74254782 1.048 ENSMUST00000119197.1
ENSMUST00000088313.4
Emd

emerin

chr4_+_89137122 1.035 ENSMUST00000058030.7
Mtap
methylthioadenosine phosphorylase
chrX_+_74254679 1.019 ENSMUST00000002029.6
Emd
emerin
chr2_-_166155272 0.990 ENSMUST00000088086.3
Sulf2
sulfatase 2
chr3_+_95622236 0.985 ENSMUST00000074353.4
Rps10-ps1
ribosomal protein S10, pseudogene 1
chr1_+_44551650 0.980 ENSMUST00000160854.1
Gulp1
GULP, engulfment adaptor PTB domain containing 1
chrX_-_37085402 0.972 ENSMUST00000115231.3
Rpl39
ribosomal protein L39
chr1_-_162740540 0.949 ENSMUST00000028016.9
ENSMUST00000182660.1
Prrc2c

proline-rich coiled-coil 2C

chr7_-_34654342 0.926 ENSMUST00000108069.1
Kctd15
potassium channel tetramerisation domain containing 15
chr19_+_6909722 0.917 ENSMUST00000116551.3
Trmt112
tRNA methyltransferase 11-2
chr8_+_33599608 0.894 ENSMUST00000009774.9
Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
chr1_-_184033998 0.883 ENSMUST00000050306.5
1700056E22Rik
RIKEN cDNA 1700056E22 gene
chr17_+_56005672 0.882 ENSMUST00000133998.1
Mpnd
MPN domain containing
chr11_-_102697710 0.880 ENSMUST00000164506.2
ENSMUST00000092569.6
Ccdc43

coiled-coil domain containing 43

chr12_-_85288419 0.874 ENSMUST00000121930.1
Acyp1
acylphosphatase 1, erythrocyte (common) type
chr11_+_75532099 0.864 ENSMUST00000169547.2
Slc43a2
solute carrier family 43, member 2
chr10_-_81202037 0.855 ENSMUST00000005069.6
Nmrk2
nicotinamide riboside kinase 2
chr1_+_173673651 0.842 ENSMUST00000085876.4
Pydc3
pyrin domain containing 3
chr8_+_69822429 0.838 ENSMUST00000164890.1
ENSMUST00000034325.4
Lpar2

lysophosphatidic acid receptor 2

chr11_-_78751656 0.837 ENSMUST00000059468.4
Fam58b
family with sequence similarity 58, member B
chr2_+_79707780 0.837 ENSMUST00000090760.2
ENSMUST00000040863.4
ENSMUST00000111780.2
Ppp1r1c


protein phosphatase 1, regulatory (inhibitor) subunit 1C


chr19_-_8929323 0.829 ENSMUST00000096242.3
Rom1
rod outer segment membrane protein 1
chr2_-_132578244 0.829 ENSMUST00000110142.1
Gpcpd1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr18_+_65582390 0.823 ENSMUST00000169679.1
ENSMUST00000183326.1
Zfp532

zinc finger protein 532

chr12_+_78861693 0.813 ENSMUST00000071230.7
Eif2s1
eukaryotic translation initiation factor 2, subunit 1 alpha
chr4_+_137993445 0.802 ENSMUST00000105831.2
ENSMUST00000084214.5
Eif4g3

eukaryotic translation initiation factor 4 gamma, 3

chr18_-_46280820 0.790 ENSMUST00000025354.3
Pggt1b
protein geranylgeranyltransferase type I, beta subunit
chr6_-_43666158 0.783 ENSMUST00000114644.2
ENSMUST00000150599.1
ENSMUST00000067888.7
Tpk1


thiamine pyrophosphokinase


chrX_-_164076100 0.736 ENSMUST00000037928.2
ENSMUST00000071667.2
Siah1b

seven in absentia 1B

chr12_+_37241633 0.732 ENSMUST00000049874.7
Agmo
alkylglycerol monooxygenase
chr15_+_77045075 0.717 ENSMUST00000127957.1
ENSMUST00000129468.1
ENSMUST00000149569.1
ENSMUST00000152949.1
Apol6



apolipoprotein L 6



chr1_+_34851832 0.717 ENSMUST00000152654.1
Plekhb2
pleckstrin homology domain containing, family B (evectins) member 2
chr15_-_100424092 0.697 ENSMUST00000154676.1
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr16_+_32877775 0.691 ENSMUST00000023489.4
ENSMUST00000171325.1
Fyttd1

forty-two-three domain containing 1

chr15_+_85132080 0.674 ENSMUST00000023067.2
Ribc2
RIB43A domain with coiled-coils 2
chrX_+_6047453 0.657 ENSMUST00000103007.3
Nudt11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr3_+_134828993 0.629 ENSMUST00000029822.4
Tacr3
tachykinin receptor 3
chr11_+_69914179 0.626 ENSMUST00000057884.5
Gps2
G protein pathway suppressor 2
chrX_-_164980279 0.597 ENSMUST00000112247.2
Mospd2
motile sperm domain containing 2
chr2_-_132578155 0.595 ENSMUST00000110136.1
ENSMUST00000124107.1
ENSMUST00000060955.5
Gpcpd1


glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)


chr1_-_183345296 0.586 ENSMUST00000109158.3
Mia3
melanoma inhibitory activity 3
chr15_-_37960849 0.579 ENSMUST00000145175.2
ENSMUST00000137636.1
ENSMUST00000146821.1
Rrm2b


ribonucleotide reductase M2 B (TP53 inducible)


chr15_-_93336800 0.577 ENSMUST00000080299.6
Yaf2
YY1 associated factor 2
chr10_-_127751707 0.569 ENSMUST00000079692.5
Gpr182
G protein-coupled receptor 182
chr3_-_41742471 0.548 ENSMUST00000026866.8
Sclt1
sodium channel and clathrin linker 1
chr2_-_132578128 0.532 ENSMUST00000028822.7
Gpcpd1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr15_-_96699698 0.528 ENSMUST00000023099.6
Slc38a2
solute carrier family 38, member 2
chr2_+_129800451 0.467 ENSMUST00000165413.2
ENSMUST00000166282.2
Stk35

serine/threonine kinase 35

chrX_+_7842056 0.465 ENSMUST00000115667.3
ENSMUST00000115668.3
ENSMUST00000115665.1
Otud5


OTU domain containing 5


chr15_-_75909289 0.440 ENSMUST00000145764.1
ENSMUST00000116440.2
ENSMUST00000151066.1
Eef1d


eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)


chr1_-_9748376 0.421 ENSMUST00000057438.6
Vcpip1
valosin containing protein (p97)/p47 complex interacting protein 1
chr2_-_166155624 0.418 ENSMUST00000109249.2
Sulf2
sulfatase 2
chr11_+_28853189 0.407 ENSMUST00000020759.5
Efemp1
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
chr4_+_115088708 0.386 ENSMUST00000171877.1
ENSMUST00000177647.1
ENSMUST00000106548.2
ENSMUST00000030488.2
Pdzk1ip1



PDZK1 interacting protein 1



chr19_-_40588338 0.380 ENSMUST00000176939.1
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr19_-_40588453 0.366 ENSMUST00000025979.6
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr3_-_94436574 0.365 ENSMUST00000029787.4
Oaz3
ornithine decarboxylase antizyme 3
chrX_+_7841800 0.358 ENSMUST00000033494.9
ENSMUST00000115666.1
Otud5

OTU domain containing 5

chr11_-_70969953 0.357 ENSMUST00000108530.1
ENSMUST00000035283.4
ENSMUST00000108531.1
Nup88


nucleoporin 88


chr8_+_114439655 0.353 ENSMUST00000004756.7
ENSMUST00000109108.2
ENSMUST00000160862.1
ENSMUST00000109107.2
Wwox



WW domain-containing oxidoreductase



chr8_-_64205970 0.347 ENSMUST00000066166.4
Tll1
tolloid-like
chrX_-_7572843 0.336 ENSMUST00000132788.1
Ppp1r3f
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr2_-_39065505 0.330 ENSMUST00000039165.8
Golga1
golgi autoantigen, golgin subfamily a, 1
chr12_-_54656496 0.330 ENSMUST00000056228.6
Sptssa
serine palmitoyltransferase, small subunit A
chr3_+_95111013 0.325 ENSMUST00000009102.8
Vps72
vacuolar protein sorting 72 (yeast)
chr11_+_75531690 0.321 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
Slc43a2



solute carrier family 43, member 2




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 11.9 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
3.6 14.3 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
3.1 9.4 GO:0043987 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) histone H3-S10 phosphorylation(GO:0043987)
2.9 11.5 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
2.6 18.4 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
2.6 7.7 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
1.7 5.2 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
1.7 5.0 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
1.4 4.1 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
1.3 3.9 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
1.3 10.2 GO:0048852 diencephalon morphogenesis(GO:0048852)
1.2 3.7 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
1.1 5.5 GO:0021764 amygdala development(GO:0021764)
1.1 5.3 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
1.1 6.3 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) macropinocytosis(GO:0044351)
1.0 5.2 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.8 12.9 GO:0030953 astral microtubule organization(GO:0030953)
0.7 3.0 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)
0.7 2.8 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.7 2.0 GO:0038044 negative regulation of receptor biosynthetic process(GO:0010871) transforming growth factor-beta secretion(GO:0038044)
0.7 8.0 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.7 2.0 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
0.6 1.9 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.6 1.8 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.6 2.3 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.6 2.3 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.6 1.7 GO:0097026 dendritic cell dendrite assembly(GO:0097026)
0.5 9.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.5 1.4 GO:0002678 positive regulation of chronic inflammatory response(GO:0002678)
0.4 1.2 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.4 2.7 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.4 4.9 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.4 1.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.4 3.2 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.3 1.0 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.3 3.0 GO:0030035 microspike assembly(GO:0030035)
0.3 13.1 GO:0006270 DNA replication initiation(GO:0006270)
0.3 1.0 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.3 8.5 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.3 2.0 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.3 1.5 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.3 1.7 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.3 2.5 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.3 1.9 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.3 1.1 GO:0002035 brain renin-angiotensin system(GO:0002035)
0.3 0.8 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.3 1.8 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 2.7 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.2 1.4 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 1.4 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.2 1.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 0.8 GO:1905077 negative regulation of interleukin-17 secretion(GO:1905077)
0.2 3.1 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.2 2.1 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.2 1.2 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.2 6.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2 1.9 GO:0000052 citrulline metabolic process(GO:0000052)
0.2 2.9 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.2 1.6 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 3.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.2 0.8 GO:0032055 negative regulation of translation in response to stress(GO:0032055)
0.2 0.8 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.2 1.2 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.2 2.7 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 2.4 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.1 1.3 GO:0002634 regulation of germinal center formation(GO:0002634)
0.1 1.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 7.7 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.1 3.6 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 0.8 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.1 0.7 GO:1901911 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 1.3 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.1 0.6 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.1 3.9 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.3 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 2.6 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.1 0.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.4 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 1.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 4.1 GO:0070613 regulation of protein processing(GO:0070613)
0.1 14.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 1.4 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 0.4 GO:0090168 Golgi reassembly(GO:0090168)
0.1 0.8 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 9.9 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.1 4.6 GO:0060042 retina morphogenesis in camera-type eye(GO:0060042)
0.1 2.0 GO:0043277 apoptotic cell clearance(GO:0043277)
0.1 0.9 GO:0019321 pentose metabolic process(GO:0019321)
0.1 0.3 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 1.2 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 0.2 GO:0000237 leptotene(GO:0000237)
0.1 1.2 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.1 2.2 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.1 1.6 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 1.1 GO:0016486 peptide hormone processing(GO:0016486)
0.1 0.9 GO:0019363 pyridine nucleotide biosynthetic process(GO:0019363)
0.1 0.5 GO:0015838 amino-acid betaine transport(GO:0015838)
0.0 0.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.4 GO:1903975 regulation of glial cell migration(GO:1903975)
0.0 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 3.8 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.8 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.0 2.4 GO:0015807 L-amino acid transport(GO:0015807)
0.0 0.8 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 4.5 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.9 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.8 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.4 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0 5.1 GO:0060348 bone development(GO:0060348)
0.0 0.3 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 0.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 3.4 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.6 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.4 GO:0009299 mRNA transcription(GO:0009299)
0.0 0.2 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.3 GO:0043486 histone exchange(GO:0043486)
0.0 1.8 GO:0030217 T cell differentiation(GO:0030217)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 11.9 GO:0032133 chromosome passenger complex(GO:0032133)
2.4 9.4 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
1.6 4.9 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
1.5 7.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.0 7.2 GO:0031298 replication fork protection complex(GO:0031298)
0.7 3.7 GO:0035189 Rb-E2F complex(GO:0035189)
0.7 2.0 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.6 1.9 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.6 2.3 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.5 2.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.5 2.0 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.4 2.7 GO:0071817 MMXD complex(GO:0071817)
0.4 1.4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.4 2.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.4 3.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.3 3.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.3 7.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 3.9 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.2 0.8 GO:0097450 astrocyte end-foot(GO:0097450)
0.2 5.0 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.2 1.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 0.8 GO:0070826 paraferritin complex(GO:0070826)
0.2 2.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.2 GO:0070578 RISC-loading complex(GO:0070578)
0.1 1.4 GO:0005642 annulate lamellae(GO:0005642)
0.1 18.6 GO:0000793 condensed chromosome(GO:0000793)
0.1 1.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 14.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.7 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 8.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 0.8 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 13.6 GO:0030027 lamellipodium(GO:0030027)
0.1 0.3 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.5 GO:0071439 clathrin complex(GO:0071439)
0.1 1.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 8.0 GO:0043296 apical junction complex(GO:0043296)
0.0 0.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)
0.0 3.5 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 2.8 GO:0016605 PML body(GO:0016605)
0.0 3.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 2.9 GO:0043679 axon terminus(GO:0043679)
0.0 2.5 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 0.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 2.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 1.5 GO:0000776 kinetochore(GO:0000776)
0.0 9.6 GO:0005813 centrosome(GO:0005813)
0.0 0.6 GO:0032590 dendrite membrane(GO:0032590)
0.0 1.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 4.0 GO:0016607 nuclear speck(GO:0016607)
0.0 1.2 GO:0005815 microtubule organizing center(GO:0005815)
0.0 0.2 GO:0005844 polysome(GO:0005844)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 17.9 GO:0050786 RAGE receptor binding(GO:0050786)
2.4 11.9 GO:0035174 histone serine kinase activity(GO:0035174)
2.4 9.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
2.3 11.5 GO:0072542 protein phosphatase activator activity(GO:0072542)
1.7 5.0 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
1.6 14.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
1.5 7.7 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.0 4.1 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
1.0 14.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.9 11.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.8 2.4 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.5 7.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.5 2.0 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.4 2.0 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.4 1.2 GO:0004568 chitinase activity(GO:0004568)
0.4 1.9 GO:0008172 S-methyltransferase activity(GO:0008172)
0.4 3.5 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.4 5.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.4 1.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.4 2.2 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.4 1.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.3 1.0 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.3 1.0 GO:0017084 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
0.3 14.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 1.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.3 1.7 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.3 3.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3 1.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 2.4 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.2 1.9 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.2 2.8 GO:0050693 LBD domain binding(GO:0050693)
0.2 4.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.2 0.9 GO:0003998 acylphosphatase activity(GO:0003998)
0.2 2.1 GO:0016406 carnitine O-acyltransferase activity(GO:0016406)
0.2 1.2 GO:0048039 ubiquinone binding(GO:0048039)
0.2 2.0 GO:0051011 microtubule minus-end binding(GO:0051011)
0.2 1.4 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.2 0.6 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.2 2.0 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.2 1.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 0.8 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.2 0.8 GO:0016778 diphosphotransferase activity(GO:0016778)
0.2 0.8 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 1.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 7.9 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 0.4 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 1.4 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 1.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340) siRNA binding(GO:0035197)
0.1 0.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 5.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.7 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 1.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.7 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 6.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 0.3 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.1 3.0 GO:0046965 retinoid X receptor binding(GO:0046965)
0.1 1.6 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 2.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.4 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 1.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 0.3 GO:2001069 glycogen binding(GO:2001069)
0.1 5.5 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 1.4 GO:0030553 cGMP binding(GO:0030553)
0.1 3.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.6 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 0.2 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.1 0.2 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 3.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 2.4 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 3.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.8 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 8.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.4 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 11.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.6 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.2 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 2.5 GO:0051117 ATPase binding(GO:0051117)
0.0 0.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 3.9 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.5 GO:0097110 scaffold protein binding(GO:0097110)
0.0 1.1 GO:0019894 kinesin binding(GO:0019894)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 8.0 GO:0003682 chromatin binding(GO:0003682)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 3.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.5 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 14.3 ST_STAT3_PATHWAY STAT3 Pathway
0.5 25.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 10.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 11.2 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.2 4.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 14.5 PID_E2F_PATHWAY E2F transcription factor network
0.1 4.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.1 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 4.8 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 16.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.1 PID_ARF6_PATHWAY Arf6 signaling events
0.1 1.4 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 1.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 1.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.4 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.2 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 2.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.2 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.2 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.8 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.4 PID_ERBB4_PATHWAY ErbB4 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 14.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
1.1 18.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
1.1 11.5 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.5 1.4 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.4 7.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.4 4.6 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.3 7.7 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 4.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 5.3 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.2 11.9 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 2.0 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.1 4.1 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 1.3 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 3.6 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 3.0 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 7.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.2 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 5.5 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 2.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.0 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 1.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 0.4 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 1.7 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 1.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.1 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 4.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME_PERK_REGULATED_GENE_EXPRESSION Genes involved in PERK regulated gene expression
0.0 1.4 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 1.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 2.0 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 12.9 REACTOME_HEMOSTASIS Genes involved in Hemostasis
0.0 0.8 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 3.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.9 REACTOME_DNA_REPAIR Genes involved in DNA Repair
0.0 1.5 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 0.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 2.0 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 3.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 1.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation