Motif ID: Tfcp2

Z-value: 1.686


Transcription factors associated with Tfcp2:

Gene SymbolEntrez IDGene Name
Tfcp2 ENSMUSG00000009733.8 Tfcp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfcp2mm10_v2_chr15_-_100551959_1005520100.581.5e-04Click!


Activity profile for motif Tfcp2.

activity profile for motif Tfcp2


Sorted Z-values histogram for motif Tfcp2

Sorted Z-values for motif Tfcp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfcp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_57511833 18.373 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr11_+_69045640 11.859 ENSMUST00000108666.1
ENSMUST00000021277.5
 Aurkb

aurora kinase B

chr11_-_22001605 10.153 ENSMUST00000006071.7
 Otx1
orthodenticle homolog 1 (Drosophila)
chr6_+_56017489 9.897 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr13_-_100786402 9.446 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chr4_-_132422394 8.439 ENSMUST00000152271.1
ENSMUST00000084170.5
 Phactr4

phosphatase and actin regulator 4

chr16_-_26989974 7.801 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr14_-_21989475 7.713 ENSMUST00000043409.7
 Zfp503
zinc finger protein 503
chr5_+_92809372 7.681 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr9_-_96862903 7.316 ENSMUST00000121077.1
ENSMUST00000124923.1
 Acpl2

acid phosphatase-like 2

chr1_+_107511489 7.248 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr2_-_5012716 7.192 ENSMUST00000027980.7
 Mcm10
minichromosome maintenance deficient 10 (S. cerevisiae)
chr12_+_24708984 7.135 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr14_+_13284774 7.116 ENSMUST00000070323.5
 Synpr
synaptoporin
chr1_+_107511416 7.053 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr11_-_84067063 6.636 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr1_+_61638819 6.599 ENSMUST00000138768.1
ENSMUST00000075374.3
 Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr2_-_102186322 6.388 ENSMUST00000111222.1
ENSMUST00000058790.5
 Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr1_-_131097535 6.327 ENSMUST00000016672.4
 Mapkapk2
MAP kinase-activated protein kinase 2
chr6_+_14901344 6.232 ENSMUST00000115477.1
 Foxp2
forkhead box P2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 18.4 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 14.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
3.6 14.3 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.3 13.1 GO:0006270 DNA replication initiation(GO:0006270)
0.8 12.9 GO:0030953 astral microtubule organization(GO:0030953)
4.0 11.9 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
2.9 11.5 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
1.3 10.2 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.5 9.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 9.9 GO:0010921 regulation of phosphatase activity(GO:0010921)
3.1 9.4 GO:0043987 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) histone H3-S10 phosphorylation(GO:0043987)
0.3 8.5 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.7 8.0 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
2.6 7.7 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 7.7 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
1.1 6.3 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) macropinocytosis(GO:0044351)
0.2 6.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.1 5.5 GO:0021764 amygdala development(GO:0021764)
1.1 5.3 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
1.7 5.2 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.6 GO:0000793 condensed chromosome(GO:0000793)
0.1 14.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 13.6 GO:0030027 lamellipodium(GO:0030027)
2.4 11.9 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 9.6 GO:0005813 centrosome(GO:0005813)
2.4 9.4 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 8.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 8.0 GO:0043296 apical junction complex(GO:0043296)
1.5 7.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.0 7.2 GO:0031298 replication fork protection complex(GO:0031298)
0.3 7.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 5.0 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
1.6 4.9 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.0 4.0 GO:0016607 nuclear speck(GO:0016607)
0.3 3.9 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.7 3.7 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 3.5 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 3.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.4 3.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.3 3.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 17.9 GO:0050786 RAGE receptor binding(GO:0050786)
1.0 14.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.6 14.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.3 14.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
2.4 11.9 GO:0035174 histone serine kinase activity(GO:0035174)
2.3 11.5 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.9 11.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 11.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
2.4 9.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 8.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 8.0 GO:0003682 chromatin binding(GO:0003682)
0.1 7.9 GO:0048487 beta-tubulin binding(GO:0048487)
1.5 7.7 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.5 7.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 6.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 5.5 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.4 5.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 5.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.7 5.0 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
1.0 4.1 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 25.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 16.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 14.5 PID_E2F_PATHWAY E2F transcription factor network
0.8 14.3 ST_STAT3_PATHWAY STAT3 Pathway
0.2 11.2 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.3 10.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 4.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 4.8 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 4.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.1 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 4.1 PID_ARF6_PATHWAY Arf6 signaling events
0.1 3.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 1.4 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.4 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 1.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.9 PID_TGFBR_PATHWAY TGF-beta receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 18.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
1.2 14.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 12.9 REACTOME_HEMOSTASIS Genes involved in Hemostasis
0.2 11.9 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
1.1 11.5 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3 7.7 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.4 7.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 7.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 5.5 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.2 5.3 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.2 4.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.4 4.6 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 4.1 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 4.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.6 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 3.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 3.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.0 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 3.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 3.0 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins