Motif ID: Tfdp1_Wt1_Egr2

Z-value: 1.745

Transcription factors associated with Tfdp1_Wt1_Egr2:

Gene SymbolEntrez IDGene Name
Egr2 ENSMUSG00000037868.9 Egr2
Tfdp1 ENSMUSG00000038482.10 Tfdp1
Wt1 ENSMUSG00000016458.7 Wt1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfdp1mm10_v2_chr8_+_13339656_133396740.421.0e-02Click!
Egr2mm10_v2_chr10_+_67537861_67537930-0.153.8e-01Click!


Activity profile for motif Tfdp1_Wt1_Egr2.

activity profile for motif Tfdp1_Wt1_Egr2


Sorted Z-values histogram for motif Tfdp1_Wt1_Egr2

Sorted Z-values for motif Tfdp1_Wt1_Egr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfdp1_Wt1_Egr2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_125490688 15.480 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr16_-_22163299 12.435 ENSMUST00000100052.4
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr7_-_34812677 11.572 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr11_+_7063423 10.828 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr13_-_56252163 9.884 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr12_+_112146187 9.152 ENSMUST00000128402.2
 Kif26a
kinesin family member 26A
chr11_+_119942763 8.985 ENSMUST00000026436.3
ENSMUST00000106231.1
ENSMUST00000075180.5
ENSMUST00000103021.3
ENSMUST00000106233.1
 Baiap2




brain-specific angiogenesis inhibitor 1-associated protein 2




chr3_-_8667033 8.683 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr11_-_95587691 8.444 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr7_+_123982799 8.085 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr14_-_39472825 7.910 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr6_-_115994953 7.905 ENSMUST00000015511.8
 Plxnd1
plexin D1
chr7_-_126082406 7.905 ENSMUST00000073935.5
 Gsg1l
GSG1-like
chr1_+_167001457 7.082 ENSMUST00000126198.1
 Fam78b
family with sequence similarity 78, member B
chr7_+_36698002 6.979 ENSMUST00000021641.6
 Tshz3
teashirt zinc finger family member 3
chr11_-_33147400 6.893 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr1_+_167001417 6.811 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B
chrX_-_52165252 6.601 ENSMUST00000033450.2
 Gpc4
glypican 4
chr11_-_4746778 6.368 ENSMUST00000009219.2
 Cabp7
calcium binding protein 7
chr17_-_66449715 6.166 ENSMUST00000086693.5
ENSMUST00000097291.3
 Soga2

SOGA family member 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.6 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.2 18.8 GO:0051028 mRNA transport(GO:0051028)
1.5 16.7 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
1.1 15.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.1 15.1 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
1.5 14.8 GO:0008063 Toll signaling pathway(GO:0008063)
0.6 14.4 GO:0051764 actin crosslink formation(GO:0051764)
0.6 14.0 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
2.0 13.9 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.1 12.0 GO:1901250 regulation of lung goblet cell differentiation(GO:1901249) negative regulation of lung goblet cell differentiation(GO:1901250)
0.2 11.9 GO:1903749 positive regulation of establishment of protein localization to mitochondrion(GO:1903749) positive regulation of protein targeting to mitochondrion(GO:1903955)
2.9 11.6 GO:0021648 vestibulocochlear nerve morphogenesis(GO:0021648)
1.9 11.5 GO:0060024 rhythmic synaptic transmission(GO:0060024)
2.7 10.8 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.7 10.8 GO:0048681 negative regulation of axon regeneration(GO:0048681)
1.1 10.7 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
1.0 10.5 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
1.5 10.4 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
1.2 10.4 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
3.3 10.0 GO:0050975 sensory perception of touch(GO:0050975)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 412 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 25.0 GO:0060076 excitatory synapse(GO:0060076)
0.6 24.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 23.0 GO:0098794 postsynapse(GO:0098794)
0.3 21.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
1.3 20.7 GO:0043196 varicosity(GO:0043196)
0.6 20.4 GO:0032839 dendrite cytoplasm(GO:0032839)
1.0 18.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.6 16.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 15.3 GO:0005871 kinesin complex(GO:0005871)
0.2 15.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.8 14.9 GO:0097470 ribbon synapse(GO:0097470)
0.6 14.7 GO:0071565 nBAF complex(GO:0071565)
0.3 14.7 GO:0002102 podosome(GO:0002102)
0.2 14.6 GO:0005643 nuclear pore(GO:0005643)
0.1 12.6 GO:0030427 site of polarized growth(GO:0030427)
0.6 11.6 GO:0032279 asymmetric synapse(GO:0032279)
0.2 11.6 GO:0043195 terminal bouton(GO:0043195)
0.3 11.5 GO:0097440 apical dendrite(GO:0097440)
0.8 11.3 GO:0035631 CD40 receptor complex(GO:0035631)
3.1 9.2 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 641 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 37.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.8 22.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.5 19.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.5 18.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.5 18.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 17.2 GO:0003777 microtubule motor activity(GO:0003777)
0.1 16.8 GO:0008017 microtubule binding(GO:0008017)
1.2 16.6 GO:0017154 semaphorin receptor activity(GO:0017154)
1.1 16.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
3.2 15.9 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
1.0 15.4 GO:0045499 chemorepellent activity(GO:0045499)
2.5 14.8 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.6 14.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.5 14.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
1.7 13.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 13.2 GO:0048365 Rac GTPase binding(GO:0048365)
1.6 12.8 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
1.0 12.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
1.1 12.3 GO:0031996 thioesterase binding(GO:0031996)
2.9 11.5 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 27.3 PID_ERBB4_PATHWAY ErbB4 signaling events
0.4 20.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
1.1 19.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.4 18.2 PID_IGF1_PATHWAY IGF1 pathway
0.5 18.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 15.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.2 14.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.4 14.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.4 13.4 PID_ALK1_PATHWAY ALK1 signaling events
0.3 12.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 11.3 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.4 10.3 PID_ARF_3PATHWAY Arf1 pathway
0.2 10.0 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 9.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 8.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 8.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.2 7.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 7.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 6.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 6.2 PID_PLK1_PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 29.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.7 25.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
1.6 19.2 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.8 15.9 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 15.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 15.6 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.8 14.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.6 13.2 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.5 13.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.4 12.3 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.3 12.1 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.5 11.9 REACTOME_KINESINS Genes involved in Kinesins
0.4 11.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 11.7 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.6 11.6 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.6 11.1 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.8 10.7 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.7 10.5 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS Genes involved in NRIF signals cell death from the nucleus
1.1 10.3 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.2 9.9 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins