Motif ID: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 1.211

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2:

Gene SymbolEntrez IDGene Name
Bhlhe41 ENSMUSG00000030256.5 Bhlhe41
Srebf1 ENSMUSG00000020538.9 Srebf1
Srebf2 ENSMUSG00000022463.7 Srebf2
Tfeb ENSMUSG00000023990.12 Tfeb
Usf1 ENSMUSG00000026641.7 Usf1
Usf2 ENSMUSG00000058239.7 Usf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srebf1mm10_v2_chr11_-_60220550_602206320.692.6e-06Click!
Tfebmm10_v2_chr17_+_47785720_477857390.521.1e-03Click!
Srebf2mm10_v2_chr15_+_82147238_82147275-0.353.5e-02Click!
Usf1mm10_v2_chr1_+_171411343_1714113840.241.6e-01Click!
Usf2mm10_v2_chr7_-_30956742_30956803-0.212.1e-01Click!


Activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2.

activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2


Sorted Z-values histogram for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Sorted Z-values for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_41519493 20.069 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr11_+_70000578 13.708 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr4_+_148039035 11.496 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr15_-_10714612 11.348 ENSMUST00000169385.1
 Rai14
retinoic acid induced 14
chr6_+_128362919 10.178 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr10_+_127063599 9.577 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr4_+_148039097 9.470 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr2_-_79456750 8.885 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr9_-_22389113 8.680 ENSMUST00000040912.7
 Anln
anillin, actin binding protein
chr4_-_34882919 8.530 ENSMUST00000098163.2
ENSMUST00000047950.5
 Zfp292

zinc finger protein 292

chr9_-_87255536 8.526 ENSMUST00000093802.4
 4922501C03Rik
RIKEN cDNA 4922501C03 gene
chr10_+_127063527 8.109 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr18_-_6135888 8.031 ENSMUST00000182383.1
ENSMUST00000062584.7
ENSMUST00000077128.6
ENSMUST00000182038.1
ENSMUST00000182213.1
 Arhgap12




Rho GTPase activating protein 12




chr9_-_91365778 7.919 ENSMUST00000065360.3
 Zic1
zinc finger protein of the cerebellum 1
chr9_-_91365756 7.787 ENSMUST00000034927.6
 Zic1
zinc finger protein of the cerebellum 1
chr3_+_159495408 7.743 ENSMUST00000120272.1
ENSMUST00000029825.7
ENSMUST00000106041.2
 Depdc1a


DEP domain containing 1a


chr1_-_82291370 7.647 ENSMUST00000069799.2
 Irs1
insulin receptor substrate 1
chr13_+_108316332 6.876 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr18_-_6136057 6.782 ENSMUST00000182559.1
 Arhgap12
Rho GTPase activating protein 12
chr5_+_64803513 6.321 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 379 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.2 21.0 GO:0070829 heterochromatin maintenance(GO:0070829)
0.3 18.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
4.4 17.7 GO:0010288 response to lead ion(GO:0010288)
0.3 15.2 GO:0007628 adult walking behavior(GO:0007628)
2.7 13.7 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
1.0 11.5 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
1.1 10.6 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.2 10.2 GO:0002011 morphogenesis of an epithelial sheet(GO:0002011)
0.1 10.0 GO:0043473 pigmentation(GO:0043473)
3.3 9.8 GO:0030421 defecation(GO:0030421)
2.3 9.1 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
2.2 8.9 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
2.2 8.8 GO:0015889 cobalamin transport(GO:0015889)
2.9 8.7 GO:1904170 regulation of bleb assembly(GO:1904170)
0.1 8.6 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
2.8 8.3 GO:1904959 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
1.5 7.6 GO:0090273 regulation of somatostatin secretion(GO:0090273)
1.2 7.0 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
2.3 6.9 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1 6.8 GO:0070936 protein K48-linked ubiquitination(GO:0070936)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.4 17.7 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.3 13.2 GO:0016235 aggresome(GO:0016235)
0.0 12.5 GO:0005887 integral component of plasma membrane(GO:0005887)
3.0 11.8 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 10.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.6 9.1 GO:0043196 varicosity(GO:0043196)
0.7 9.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 8.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
1.7 8.7 GO:0005826 actomyosin contractile ring(GO:0005826)
2.5 7.6 GO:0005899 insulin receptor complex(GO:0005899)
1.0 6.9 GO:0033503 HULC complex(GO:0033503)
0.4 6.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
1.7 6.7 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.2 6.6 GO:0030904 retromer complex(GO:0030904)
0.3 6.3 GO:0010369 chromocenter(GO:0010369)
0.4 6.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.3 5.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 5.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.7 5.5 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 5.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 262 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 38.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 37.7 GO:0005096 GTPase activator activity(GO:0005096)
7.0 21.0 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.4 19.3 GO:0030332 cyclin binding(GO:0030332)
0.4 14.3 GO:0005109 frizzled binding(GO:0005109)
1.6 10.9 GO:0031419 cobalamin binding(GO:0031419)
0.2 9.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 9.5 GO:0008083 growth factor activity(GO:0008083)
0.2 9.0 GO:0003714 transcription corepressor activity(GO:0003714)
2.8 8.3 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
1.3 7.9 GO:0001069 regulatory region RNA binding(GO:0001069)
0.8 7.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 7.6 GO:0017022 myosin binding(GO:0017022)
0.2 7.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.5 6.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 5.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.5 5.4 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.1 5.3 GO:0019003 GDP binding(GO:0019003)
0.7 5.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
1.2 5.0 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 18.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5 14.1 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.3 12.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 7.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.3 7.0 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 6.5 PID_PLK1_PATHWAY PLK1 signaling events
0.1 5.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.5 4.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 4.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.3 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 3.6 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 3.6 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 3.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 3.0 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 3.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 2.8 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 2.7 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.5 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 2.4 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.4 PID_ERBB4_PATHWAY ErbB4 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 18.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.5 15.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 14.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 11.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 11.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 9.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.3 8.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.2 7.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 7.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4 6.7 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.4 5.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.1 5.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 5.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.6 5.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.5 4.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 4.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 4.7 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 4.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 4.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription