Motif ID: Tgif1_Meis3

Z-value: 1.464

Transcription factors associated with Tgif1_Meis3:

Gene SymbolEntrez IDGene Name
Meis3 ENSMUSG00000041420.12 Meis3
Tgif1 ENSMUSG00000047407.11 Tgif1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif1mm10_v2_chr17_-_70853482_70853546-0.796.2e-09Click!
Meis3mm10_v2_chr7_+_16175275_16175438-0.553.7e-04Click!


Activity profile for motif Tgif1_Meis3.

activity profile for motif Tgif1_Meis3


Sorted Z-values histogram for motif Tgif1_Meis3

Sorted Z-values for motif Tgif1_Meis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif1_Meis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_49246131 13.595 ENSMUST00000064395.6
 Nav2
neuron navigator 2
chr15_-_66831625 12.915 ENSMUST00000164163.1
 Sla
src-like adaptor
chr15_-_66801577 10.321 ENSMUST00000168589.1
 Sla
src-like adaptor
chr8_+_70501116 7.815 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr18_-_66291770 6.714 ENSMUST00000130300.1
 Ccbe1
collagen and calcium binding EGF domains 1
chr3_+_26331150 6.669 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr7_+_49246812 6.530 ENSMUST00000184945.1
 Nav2
neuron navigator 2
chr4_+_102254739 6.317 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_+_102254993 6.028 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr7_+_112225856 5.942 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr10_-_125328957 5.617 ENSMUST00000063318.2
 Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr4_-_64046925 5.533 ENSMUST00000107377.3
 Tnc
tenascin C
chr1_+_159737510 5.162 ENSMUST00000111669.3
 Tnr
tenascin R
chr5_-_67847360 4.564 ENSMUST00000072971.6
 Atp8a1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
chr13_+_118714678 4.477 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr19_-_57182293 4.351 ENSMUST00000133369.1
 Ablim1
actin-binding LIM protein 1
chr9_-_29963112 4.308 ENSMUST00000075069.4
 Ntm
neurotrimin
chr19_-_6840590 4.302 ENSMUST00000170516.2
ENSMUST00000025903.5
 Rps6ka4

ribosomal protein S6 kinase, polypeptide 4

chr8_-_84800024 4.052 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr5_-_67847400 3.993 ENSMUST00000113652.1
ENSMUST00000113651.1
ENSMUST00000037380.8
 Atp8a1


ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 565 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.0 20.1 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.3 20.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.4 17.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 12.6 GO:0034605 cellular response to heat(GO:0034605)
1.3 9.3 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 8.4 GO:0071805 potassium ion transmembrane transport(GO:0071805)
2.1 8.3 GO:0060667 fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915)
0.2 8.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.7 8.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
1.3 7.7 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.3 7.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
1.7 6.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.8 6.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 6.9 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
1.7 6.7 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.1 6.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 6.6 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
1.6 6.5 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
1.2 6.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
1.5 6.1 GO:1901475 pyruvate transmembrane transport(GO:1901475)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 36.8 GO:0031224 intrinsic component of membrane(GO:0031224)
1.6 25.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 25.2 GO:0009986 cell surface(GO:0009986)
0.2 24.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3 22.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 20.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.6 15.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.5 11.5 GO:0071565 nBAF complex(GO:0071565)
0.1 7.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 7.1 GO:0005802 trans-Golgi network(GO:0005802)
2.3 6.9 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 6.7 GO:0000139 Golgi membrane(GO:0000139)
0.1 6.1 GO:0005581 collagen trimer(GO:0005581)
0.0 6.0 GO:0001650 fibrillar center(GO:0001650)
0.1 5.8 GO:0016605 PML body(GO:0016605)
0.3 5.3 GO:0032279 asymmetric synapse(GO:0032279)
1.7 5.2 GO:0072534 perineuronal net(GO:0072534)
1.0 5.2 GO:0044316 cone cell pedicle(GO:0044316)
0.5 4.5 GO:0042587 glycogen granule(GO:0042587)
0.3 4.5 GO:0043083 synaptic cleft(GO:0043083)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 353 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 27.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.5 22.4 GO:0030552 cAMP binding(GO:0030552)
0.2 19.9 GO:0008201 heparin binding(GO:0008201)
0.5 11.2 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.4 10.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
1.5 9.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.3 9.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.3 8.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 8.2 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 8.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 8.1 GO:0017124 SH3 domain binding(GO:0017124)
0.1 7.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 7.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 6.8 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 6.6 GO:0044325 ion channel binding(GO:0044325)
1.5 6.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.9 5.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 5.4 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2 5.2 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.9 5.1 GO:0045545 syndecan binding(GO:0045545)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 12.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 9.1 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 8.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 8.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 6.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 6.2 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 4.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 4.3 PID_ARF_3PATHWAY Arf1 pathway
0.1 4.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 4.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 4.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.0 SIG_CHEMOTAXIS Genes related to chemotaxis
0.1 3.9 PID_FGF_PATHWAY FGF signaling pathway
0.1 3.7 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 3.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 3.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 3.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 3.2 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 22.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 10.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 10.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 9.3 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.6 7.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.6 7.5 REACTOME_ACTIVATED_POINT_MUTANTS_OF_FGFR2 Genes involved in Activated point mutants of FGFR2
0.2 6.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 6.7 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.3 6.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 6.0 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 5.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 5.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 5.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 4.7 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 4.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.5 4.6 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 4.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 4.0 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 4.0 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 3.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins