Motif ID: Tgif2_Tgif2lx1_Tgif2lx2
Z-value: 0.987
Transcription factors associated with Tgif2_Tgif2lx1_Tgif2lx2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tgif2 | ENSMUSG00000062175.7 | Tgif2 |
| Tgif2lx1 | ENSMUSG00000061283.4 | Tgif2lx1 |
| Tgif2lx2 | ENSMUSG00000063242.6 | Tgif2lx2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tgif2 | mm10_v2_chr2_+_156840966_156841017 | 0.79 | 8.0e-09 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 16.6 | GO:0021905 | pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937) |
| 0.7 | 6.5 | GO:0046459 | short-chain fatty acid metabolic process(GO:0046459) |
| 0.6 | 5.8 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.6 | 1.7 | GO:1901052 | sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053) |
| 0.5 | 1.9 | GO:2000318 | positive regulation of T-helper 17 type immune response(GO:2000318) |
| 0.4 | 1.1 | GO:2001187 | natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
| 0.4 | 4.0 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.4 | 1.8 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.3 | 1.4 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.3 | 1.0 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
| 0.2 | 1.1 | GO:0048478 | replication fork protection(GO:0048478) |
| 0.2 | 0.9 | GO:0015744 | succinate transport(GO:0015744) |
| 0.2 | 0.6 | GO:0003195 | tricuspid valve formation(GO:0003195) right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.2 | 0.9 | GO:1903181 | regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) |
| 0.2 | 2.9 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.2 | 2.5 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.2 | 0.5 | GO:0048239 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.1 | 1.6 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.1 | 0.4 | GO:0021852 | pyramidal neuron migration(GO:0021852) |
| 0.1 | 3.1 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.1 | 1.6 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.1 | 0.6 | GO:0042701 | progesterone secretion(GO:0042701) |
| 0.1 | 0.2 | GO:0042713 | sperm ejaculation(GO:0042713) |
| 0.1 | 0.7 | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
| 0.1 | 1.7 | GO:0045836 | positive regulation of meiotic nuclear division(GO:0045836) |
| 0.1 | 2.5 | GO:0007617 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
| 0.1 | 5.0 | GO:0030901 | midbrain development(GO:0030901) |
| 0.1 | 3.4 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.1 | 2.7 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.1 | 10.1 | GO:0030177 | positive regulation of Wnt signaling pathway(GO:0030177) |
| 0.1 | 2.6 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 0.1 | 0.6 | GO:0032049 | cardiolipin biosynthetic process(GO:0032049) |
| 0.1 | 0.4 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 0.1 | 0.3 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.1 | 0.2 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.1 | 0.4 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) |
| 0.1 | 0.4 | GO:0070092 | regulation of glucagon secretion(GO:0070092) |
| 0.1 | 1.6 | GO:0031365 | N-terminal protein amino acid modification(GO:0031365) |
| 0.0 | 0.4 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.0 | 0.1 | GO:0097051 | establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) |
| 0.0 | 0.6 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 1.7 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 0.7 | GO:0042407 | cristae formation(GO:0042407) |
| 0.0 | 2.7 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
| 0.0 | 0.2 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.0 | 0.8 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
| 0.0 | 0.1 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.0 | 0.8 | GO:0048266 | behavioral response to pain(GO:0048266) |
| 0.0 | 1.2 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.1 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.0 | 1.2 | GO:0048246 | macrophage chemotaxis(GO:0048246) |
| 0.0 | 0.6 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.0 | 0.2 | GO:0009405 | pathogenesis(GO:0009405) |
| 0.0 | 1.0 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.0 | 3.6 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 0.4 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.0 | 0.1 | GO:0061034 | olfactory bulb mitral cell layer development(GO:0061034) |
| 0.0 | 0.1 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.0 | 0.5 | GO:0007099 | centriole replication(GO:0007099) |
| 0.0 | 0.1 | GO:1900112 | regulation of histone H3-K9 trimethylation(GO:1900112) negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.0 | 0.1 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
| 0.0 | 0.3 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.0 | 0.2 | GO:1904816 | positive regulation of protein localization to chromosome, telomeric region(GO:1904816) |
| 0.0 | 1.4 | GO:0000910 | cytokinesis(GO:0000910) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.7 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.4 | 2.6 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.3 | 6.0 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 1.8 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.2 | 1.1 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.1 | 0.7 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.1 | 1.5 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.1 | 0.4 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 0.5 | GO:0098536 | deuterosome(GO:0098536) |
| 0.1 | 0.7 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.1 | 1.1 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 24.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 0.4 | GO:0071014 | post-mRNA release spliceosomal complex(GO:0071014) |
| 0.0 | 0.6 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 3.4 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 0.5 | GO:0000783 | telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) |
| 0.0 | 1.3 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 0.6 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.0 | 3.1 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 8.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 0.7 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 1.0 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.1 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 1.2 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 1.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.1 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.0 | 0.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.2 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.0 | 2.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.1 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
| 0.0 | 0.4 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.0 | 0.0 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.0 | 0.1 | GO:0045252 | dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 0.1 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 0.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 16.6 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.6 | 1.7 | GO:0046997 | sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997) |
| 0.5 | 2.4 | GO:0015440 | peptide-transporting ATPase activity(GO:0015440) |
| 0.4 | 6.5 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.3 | 6.7 | GO:0015172 | acidic amino acid transmembrane transporter activity(GO:0015172) |
| 0.2 | 1.5 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.2 | 1.6 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.2 | 2.7 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.2 | 1.1 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.2 | 1.8 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 0.6 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.1 | 0.9 | GO:0050897 | cobalt ion binding(GO:0050897) |
| 0.1 | 1.4 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 1.2 | GO:0016151 | nickel cation binding(GO:0016151) |
| 0.1 | 6.5 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 1.9 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.1 | 0.7 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.1 | 1.7 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.1 | 0.6 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
| 0.1 | 0.6 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.1 | 0.5 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
| 0.1 | 1.7 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 0.2 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.1 | 0.8 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
| 0.0 | 0.1 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 0.1 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.0 | 0.2 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 0.1 | GO:0034602 | oxoglutarate dehydrogenase (NAD+) activity(GO:0034602) |
| 0.0 | 6.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 4.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 1.6 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
| 0.0 | 0.4 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 1.2 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.2 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.0 | 0.1 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.0 | 0.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.6 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.2 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 0.0 | GO:0034597 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
| 0.0 | 0.1 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.1 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.8 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.1 | 2.7 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.4 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 0.6 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.9 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.3 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.1 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.9 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.0 | 1.4 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.7 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.6 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 0.2 | PID_AURORA_A_PATHWAY | Aurora A signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 16.6 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.4 | 6.5 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.2 | 1.4 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 0.8 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 5.5 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 0.9 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 2.7 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.6 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 0.9 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.2 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 1.0 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 5.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 2.9 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.7 | REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.0 | 0.9 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.2 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.0 | 0.9 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 0.1 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.3 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
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