Motif ID: Thra
Z-value: 0.632
Transcription factors associated with Thra:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Thra | ENSMUSG00000058756.7 | Thra |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Thra | mm10_v2_chr11_+_98741805_98741816 | -0.56 | 3.1e-04 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 87 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.3 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.1 | 3.2 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) |
| 0.2 | 3.1 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.5 | 2.5 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.3 | 2.0 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.6 | 1.9 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.3 | 1.9 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 1.9 | GO:0021979 | hypothalamus cell differentiation(GO:0021979) |
| 0.3 | 1.8 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.2 | 1.8 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 1.7 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.1 | 1.7 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.3 | 1.6 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.1 | 1.6 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.1 | 1.5 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.5 | 1.4 | GO:0021849 | neuroblast division in subventricular zone(GO:0021849) |
| 0.4 | 1.3 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
| 0.2 | 1.3 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.2 | 1.3 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.2 | 1.3 | GO:0035902 | response to immobilization stress(GO:0035902) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 43 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 3.1 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 2.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 2.0 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 1.8 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 1.8 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 1.8 | GO:0000776 | kinetochore(GO:0000776) |
| 0.1 | 1.7 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.1 | 1.7 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.0 | 1.5 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 1.3 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.0 | 1.3 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 1.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 1.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 1.1 | GO:0000922 | spindle pole(GO:0000922) |
| 0.2 | 1.0 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.2 | 1.0 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.0 | 1.0 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 0.8 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 0.8 | GO:0005876 | spindle microtubule(GO:0005876) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 57 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 3.1 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.3 | 2.5 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.0 | 2.1 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.4 | 2.0 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.1 | 2.0 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.1 | 1.8 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.0 | 1.8 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 1.6 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 1.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 1.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.3 | 1.3 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.3 | 1.3 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.1 | 1.3 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.1 | 1.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 1.3 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
| 0.1 | 1.2 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 1.2 | GO:0030553 | cGMP binding(GO:0030553) 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.2 | 1.1 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 1.0 | GO:0043495 | protein anchor(GO:0043495) |
Gene overrepresentation in C2:CP category:
Showing 1 to 15 of 15 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 2.6 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.5 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.6 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 1.3 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.3 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.2 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 1.0 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.8 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.8 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 0.7 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.7 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.6 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.3 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.1 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 27 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 3.3 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 2.8 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.2 | 2.1 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 2.0 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 1.9 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.1 | 1.7 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.6 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.3 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.2 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.1 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.9 | REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.0 | 0.8 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 0.7 | REACTOME_COMPLEMENT_CASCADE | Genes involved in Complement cascade |
| 0.1 | 0.7 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 0.7 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.6 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.1 | 0.5 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 0.5 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 0.4 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
