Motif ID: Thrb

Z-value: 0.434


Transcription factors associated with Thrb:

Gene SymbolEntrez IDGene Name
Thrb ENSMUSG00000021779.10 Thrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Thrbmm10_v2_chr14_+_17660956_176609630.047.9e-01Click!


Activity profile for motif Thrb.

activity profile for motif Thrb


Sorted Z-values histogram for motif Thrb

Sorted Z-values for motif Thrb



Network of associatons between targets according to the STRING database.



First level regulatory network of Thrb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_25470031 3.609 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr2_-_25469742 3.097 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr12_+_112620030 1.710 ENSMUST00000180015.1
ENSMUST00000021726.6
 Adssl1

adenylosuccinate synthetase like 1

chr9_-_107668967 1.490 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr5_-_111761697 1.128 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr16_+_36934976 1.093 ENSMUST00000023531.8
 Hcls1
hematopoietic cell specific Lyn substrate 1
chr3_+_14863495 1.071 ENSMUST00000029076.4
 Car3
carbonic anhydrase 3
chr12_+_108334341 0.901 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr5_-_92278155 0.785 ENSMUST00000159345.1
ENSMUST00000113102.3
 Naaa

N-acylethanolamine acid amidase

chr11_+_109485606 0.766 ENSMUST00000106697.1
 Arsg
arylsulfatase G
chr3_-_36475688 0.648 ENSMUST00000029266.8
 Anxa5
annexin A5
chr11_-_103344651 0.636 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chr11_-_115612491 0.471 ENSMUST00000106507.2
 Mif4gd
MIF4G domain containing
chr4_+_20042046 0.407 ENSMUST00000098242.3
 Ggh
gamma-glutamyl hydrolase
chr3_-_116712198 0.281 ENSMUST00000120120.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr5_-_30461902 0.227 ENSMUST00000133509.1
ENSMUST00000074171.6
ENSMUST00000114747.2
ENSMUST00000144125.1
 Otof



otoferlin



chr4_-_148444744 0.203 ENSMUST00000051633.2
 Ubiad1
UbiA prenyltransferase domain containing 1
chr2_+_92382911 0.153 ENSMUST00000054316.2
ENSMUST00000111280.2
 1700029I15Rik

RIKEN cDNA 1700029I15 gene

chr16_-_17144415 0.150 ENSMUST00000115709.1
 Ccdc116
coiled-coil domain containing 116
chr16_+_37916440 0.134 ENSMUST00000061274.7
 Gpr156
G protein-coupled receptor 156
chr14_-_61360395 0.133 ENSMUST00000022494.8
 Ebpl
emopamil binding protein-like
chr1_-_83408190 0.130 ENSMUST00000160953.1
 Sphkap
SPHK1 interactor, AKAP domain containing
chr9_-_102626095 0.119 ENSMUST00000093791.3
 Cep63
centrosomal protein 63
chr16_+_32419696 0.118 ENSMUST00000014220.8
ENSMUST00000080316.7
 Tctex1d2

Tctex1 domain containing 2

chr1_-_137969213 0.111 ENSMUST00000182680.1
ENSMUST00000182424.1
 Gm26936

predicted gene, 26936

chr13_-_92530813 0.111 ENSMUST00000022217.8
 Zfyve16
zinc finger, FYVE domain containing 16
chr2_-_24049389 0.108 ENSMUST00000051416.5
 Hnmt
histamine N-methyltransferase
chrX_-_78583882 0.101 ENSMUST00000114025.1
ENSMUST00000134602.1
ENSMUST00000114024.2
 Prrg1


proline rich Gla (G-carboxyglutamic acid) 1


chr15_-_100669496 0.085 ENSMUST00000182814.1
ENSMUST00000182068.1
 Bin2

bridging integrator 2

chr3_+_67374116 0.085 ENSMUST00000061322.8
 Mlf1
myeloid leukemia factor 1
chr4_+_152178126 0.054 ENSMUST00000075363.3
 Acot7
acyl-CoA thioesterase 7
chrX_-_78583782 0.054 ENSMUST00000177904.1
 Prrg1
proline rich Gla (G-carboxyglutamic acid) 1
chr3_+_67374091 0.044 ENSMUST00000077916.5
 Mlf1
myeloid leukemia factor 1
chr9_+_102626278 0.043 ENSMUST00000038673.7
 Anapc13
anaphase promoting complex subunit 13
chr9_-_102626509 0.026 ENSMUST00000161645.1
ENSMUST00000162297.1
ENSMUST00000162655.1
 Cep63


centrosomal protein 63


chr11_+_49203465 0.019 ENSMUST00000150284.1
ENSMUST00000109197.1
ENSMUST00000151228.1
 Zfp62


zinc finger protein 62


chr2_+_152962485 0.015 ENSMUST00000099197.2
ENSMUST00000103155.3
 Ttll9

tubulin tyrosine ligase-like family, member 9

chr7_+_101896817 0.011 ENSMUST00000143835.1
 Anapc15
anaphase prompoting complex C subunit 15

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.7 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.6 1.7 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.3 1.5 GO:0015817 glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365)
0.2 0.6 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.2 1.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.4 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.9 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.3 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 0.2 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 1.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.1 GO:0001692 histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805)
0.0 0.1 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.1 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.0 0.1 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.1 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.0 0.2 GO:0048787 presynaptic active zone membrane(GO:0048787)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.7 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.5 1.5 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.1 1.1 GO:0016151 nickel cation binding(GO:0016151)
0.1 0.4 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.8 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.9 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.7 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.2 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 1.7 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.8 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane