Motif ID: Tlx2

Z-value: 1.110


Transcription factors associated with Tlx2:

Gene SymbolEntrez IDGene Name
Tlx2 ENSMUSG00000068327.3 Tlx2



Activity profile for motif Tlx2.

activity profile for motif Tlx2


Sorted Z-values histogram for motif Tlx2

Sorted Z-values for motif Tlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_82074639 5.171 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr9_-_21037775 4.523 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr15_+_21111452 4.494 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr16_+_91225550 4.260 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr8_+_94772009 4.102 ENSMUST00000034230.5
 Cx3cl1
chemokine (C-X3-C motif) ligand 1
chr15_+_54745702 3.876 ENSMUST00000050027.8
 Nov
nephroblastoma overexpressed gene
chr9_+_111311674 3.850 ENSMUST00000078626.3
 Trank1
tetratricopeptide repeat and ankyrin repeat containing 1
chr19_+_6401675 3.461 ENSMUST00000113471.1
ENSMUST00000113469.2
 Rasgrp2

RAS, guanyl releasing protein 2

chrX_-_162565514 3.327 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr6_+_108660772 3.209 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr17_+_68837062 2.984 ENSMUST00000178545.1
 Tmem200c
transmembrane protein 200C
chr9_-_107710475 2.937 ENSMUST00000080560.3
 Sema3f
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr19_-_24031006 2.798 ENSMUST00000096164.4
 Fam189a2
family with sequence similarity 189, member A2
chr14_+_66344369 2.782 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
 Stmn4



stathmin-like 4



chr6_+_108660616 2.780 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr14_+_66344296 2.779 ENSMUST00000152093.1
ENSMUST00000074523.6
 Stmn4

stathmin-like 4

chr11_-_51650813 2.761 ENSMUST00000142721.1
ENSMUST00000156835.1
ENSMUST00000001080.9
 N4bp3


NEDD4 binding protein 3


chr9_-_29412204 2.742 ENSMUST00000115237.1
 Ntm
neurotrimin
chr13_-_49309217 2.686 ENSMUST00000110087.2
 Fgd3
FYVE, RhoGEF and PH domain containing 3
chr13_+_13784278 2.613 ENSMUST00000021734.7
 Gng4
guanine nucleotide binding protein (G protein), gamma 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 220 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.6 GO:0009648 photoperiodism(GO:0009648)
0.8 5.3 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
1.7 5.2 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 4.6 GO:0034605 cellular response to heat(GO:0034605)
1.4 4.3 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 4.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.0 4.1 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
1.3 3.9 GO:1990523 bone regeneration(GO:1990523)
0.0 3.7 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.1 3.5 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 3.5 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.3 3.4 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.4 3.1 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.2 3.0 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
1.0 2.9 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.7 2.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.5 2.9 GO:0097491 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.4 2.8 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.5 2.7 GO:0034436 glycoprotein transport(GO:0034436)
0.5 2.7 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 5.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 3.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 3.4 GO:0000242 pericentriolar material(GO:0000242)
0.1 3.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.4 GO:0043195 terminal bouton(GO:0043195)
0.3 3.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 3.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 2.7 GO:0005923 bicellular tight junction(GO:0005923)
0.2 2.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 2.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.6 GO:0031965 nuclear membrane(GO:0031965)
0.2 2.5 GO:0097449 astrocyte projection(GO:0097449)
0.0 2.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.3 GO:0005509 calcium ion binding(GO:0005509)
0.6 7.6 GO:0004016 adenylate cyclase activity(GO:0004016)
1.0 6.0 GO:0043426 MRF binding(GO:0043426)
0.2 6.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 5.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 5.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 4.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 4.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 4.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 4.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
1.3 4.0 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.1 3.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.4 3.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 3.2 GO:0030165 PDZ domain binding(GO:0030165)
0.4 3.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.5 2.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 2.9 GO:0016936 galactoside binding(GO:0016936)
0.2 2.9 GO:0045499 chemorepellent activity(GO:0045499)
0.0 2.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.6 2.8 GO:0042610 CD8 receptor binding(GO:0042610)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 6.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 6.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 6.1 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 5.4 PID_ARF_3PATHWAY Arf1 pathway
0.0 5.3 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 3.9 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 3.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 3.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 2.8 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.1 2.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.0 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 1.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 1.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.6 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 1.4 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.2 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.1 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 6.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 5.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 5.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 5.7 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 5.0 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 3.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 3.1 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.1 3.1 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.5 2.8 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 2.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 2.6 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 2.5 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.2 2.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 2.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 2.1 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 2.1 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.7 2.0 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.1 2.0 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 1.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation