Motif ID: Trp53

Z-value: 1.312


Transcription factors associated with Trp53:

Gene SymbolEntrez IDGene Name
Trp53 ENSMUSG00000059552.7 Trp53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp53mm10_v2_chr11_+_69580392_695804190.212.1e-01Click!


Activity profile for motif Trp53.

activity profile for motif Trp53


Sorted Z-values histogram for motif Trp53

Sorted Z-values for motif Trp53



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp53

PNG image of the network

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Top targets:


Showing 1 to 20 of 148 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_69206146 14.430 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr1_+_6487231 12.793 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr2_-_69206133 11.648 ENSMUST00000112320.1
 Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr17_-_33890584 10.892 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1

chr8_+_94977101 10.209 ENSMUST00000179619.1
 Gpr56
G protein-coupled receptor 56
chr17_-_33890539 9.720 ENSMUST00000173386.1
 Kifc1
kinesin family member C1
chr17_+_29090969 9.558 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr14_+_13454010 9.041 ENSMUST00000112656.2
 Synpr
synaptoporin
chr3_-_75956888 7.705 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
 Golim4


golgi integral membrane protein 4


chr15_+_85859689 7.142 ENSMUST00000170629.1
 Gtse1
G two S phase expressed protein 1
chr8_-_22185758 6.932 ENSMUST00000046916.7
 Ckap2
cytoskeleton associated protein 2
chr11_-_102925086 6.744 ENSMUST00000021311.9
 Kif18b
kinesin family member 18B
chr14_+_13453937 6.684 ENSMUST00000153954.1
 Synpr
synaptoporin
chr14_+_73237891 6.440 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr10_+_93641041 4.946 ENSMUST00000020204.4
 Ntn4
netrin 4
chr14_-_34374617 4.664 ENSMUST00000023826.4
 Sncg
synuclein, gamma
chr14_-_54926784 4.548 ENSMUST00000022813.6
 Efs
embryonal Fyn-associated substrate
chr9_-_106158109 4.377 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
 Glyctk



glycerate kinase



chr15_-_98004695 4.341 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr15_-_98004634 4.196 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 26.1 GO:0007052 mitotic spindle organization(GO:0007052)
6.9 20.6 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.2 13.7 GO:0007019 microtubule depolymerization(GO:0007019)
1.1 12.8 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.4 12.2 GO:0071493 cellular response to UV-B(GO:0071493)
0.7 10.1 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.8 8.5 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.5 7.6 GO:0070986 left/right axis specification(GO:0070986)
0.3 6.4 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
1.0 4.9 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.2 4.7 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.2 3.8 GO:0086016 AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027)
1.2 3.7 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.9 3.7 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
0.8 3.4 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 3.4 GO:0042113 B cell activation(GO:0042113)
1.1 3.2 GO:0002865 immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.5 3.2 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.5 2.9 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.5 2.7 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 26.1 GO:0031262 Ndc80 complex(GO:0031262)
1.1 21.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.7 15.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 14.6 GO:0032993 protein-DNA complex(GO:0032993)
0.2 14.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
2.5 10.1 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
3.2 9.6 GO:0070557 PCNA-p21 complex(GO:0070557)
0.7 8.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 8.0 GO:0036126 sperm flagellum(GO:0036126)
1.1 6.7 GO:0000235 astral microtubule(GO:0000235)
0.0 6.4 GO:0043679 axon terminus(GO:0043679)
0.3 3.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 3.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.3 3.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 3.4 GO:0005871 kinesin complex(GO:0005871)
0.0 3.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 2.7 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 2.7 GO:0097440 apical dendrite(GO:0097440)
0.4 2.6 GO:0045179 apical cortex(GO:0045179)
0.0 2.6 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 20.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 15.2 GO:0001047 core promoter binding(GO:0001047)
0.1 10.2 GO:0003777 microtubule motor activity(GO:0003777)
0.4 10.1 GO:0000400 four-way junction DNA binding(GO:0000400)
3.2 9.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.7 8.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.9 6.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 4.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.5 3.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.3 3.7 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.4 3.6 GO:0043237 laminin-1 binding(GO:0043237)
0.1 3.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.4 GO:0019905 syntaxin binding(GO:0019905)
0.4 3.2 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.3 2.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 2.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.9 2.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 2.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 2.2 GO:0046790 virion binding(GO:0046790)
0.2 2.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 9.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 8.5 NABA_COLLAGENS Genes encoding collagen proteins
0.1 4.6 PID_E2F_PATHWAY E2F transcription factor network
0.2 3.5 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 3.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.9 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 2.4 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.2 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.8 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.3 PID_IL1_PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 26.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.8 20.6 REACTOME_KINESINS Genes involved in Kinesins
0.1 10.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.4 9.6 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 8.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.7 6.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 4.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 3.7 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 2.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 2.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 2.6 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.1 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 1.6 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.5 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.3 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 0.8 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade