Motif ID: Trp63

Z-value: 0.842


Transcription factors associated with Trp63:

Gene SymbolEntrez IDGene Name
Trp63 ENSMUSG00000022510.8 Trp63



Activity profile for motif Trp63.

activity profile for motif Trp63


Sorted Z-values histogram for motif Trp63

Sorted Z-values for motif Trp63



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp63

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_116038734 8.051 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr17_+_29090969 5.626 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr11_-_101466222 4.471 ENSMUST00000040430.7
 Vat1
vesicle amine transport protein 1 homolog (T californica)
chr6_+_34709442 4.413 ENSMUST00000115021.1
 Cald1
caldesmon 1
chr6_+_34709610 4.392 ENSMUST00000031775.6
 Cald1
caldesmon 1
chr1_-_9700209 4.018 ENSMUST00000088658.4
 Mybl1
myeloblastosis oncogene-like 1
chr12_-_108003414 3.557 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr12_-_108003594 3.430 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr7_-_141443314 3.347 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr7_-_37772868 2.697 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr19_-_5875268 2.656 ENSMUST00000025728.6
 Frmd8
FERM domain containing 8
chr19_-_5875210 2.653 ENSMUST00000155227.1
 Frmd8
FERM domain containing 8
chr8_-_31918203 2.552 ENSMUST00000073884.4
 Nrg1
neuregulin 1
chr8_-_87959560 2.522 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr11_-_69948145 2.416 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
 Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr11_-_106487796 2.075 ENSMUST00000001059.2
ENSMUST00000106799.1
ENSMUST00000106800.1
 Ern1


endoplasmic reticulum (ER) to nucleus signalling 1


chr2_-_170427828 1.821 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
 Bcas1


breast carcinoma amplified sequence 1


chr11_-_106487833 1.734 ENSMUST00000106801.1
 Ern1
endoplasmic reticulum (ER) to nucleus signalling 1
chr3_-_108402589 1.514 ENSMUST00000147565.1
 Celsr2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr10_-_80671976 1.364 ENSMUST00000003433.6
 Mknk2
MAP kinase-interacting serine/threonine kinase 2
chr4_-_96591555 1.326 ENSMUST00000055693.8
 Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr2_+_59612034 1.071 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr7_-_65370908 1.052 ENSMUST00000032729.6
 Tjp1
tight junction protein 1
chr5_-_5265224 1.004 ENSMUST00000115450.1
 Cdk14
cyclin-dependent kinase 14
chr4_-_134018829 0.944 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr15_+_76696725 0.859 ENSMUST00000023203.4
 Gpt
glutamic pyruvic transaminase, soluble
chr8_-_47352348 0.758 ENSMUST00000110367.2
 Stox2
storkhead box 2
chrX_+_159255919 0.721 ENSMUST00000112492.1
 Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr16_+_37868383 0.690 ENSMUST00000078717.6
 Lrrc58
leucine rich repeat containing 58
chr18_-_15718046 0.687 ENSMUST00000053017.6
 Chst9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr11_+_98863610 0.649 ENSMUST00000142414.1
ENSMUST00000037480.8
 Wipf2

WAS/WASL interacting protein family, member 2

chrX_+_159255782 0.539 ENSMUST00000126686.1
ENSMUST00000033671.6
 Rps6ka3

ribosomal protein S6 kinase polypeptide 3

chr7_-_65371210 0.489 ENSMUST00000102592.3
 Tjp1
tight junction protein 1
chr7_-_126160992 0.426 ENSMUST00000164741.1
 Xpo6
exportin 6
chr10_-_61452658 0.265 ENSMUST00000167087.1
ENSMUST00000020288.7
 Eif4ebp2

eukaryotic translation initiation factor 4E binding protein 2

chr8_+_84686300 0.221 ENSMUST00000177531.1
 Trmt1
tRNA methyltransferase 1
chr19_-_6080311 0.177 ENSMUST00000159832.1
 Vps51
vacuolar protein sorting 51 homolog (S. cerevisiae)
chr14_-_122451109 0.132 ENSMUST00000081580.2
 Gm5089
predicted gene 5089
chr4_+_150855064 0.090 ENSMUST00000030811.1
 Errfi1
ERBB receptor feedback inhibitor 1
chr2_+_25054396 0.056 ENSMUST00000102931.4
ENSMUST00000074422.7
ENSMUST00000132172.1
ENSMUST00000114388.1
ENSMUST00000114386.1
 Nsmf




NMDA receptor synaptonuclear signaling and neuronal migration factor




chr7_-_114254659 0.051 ENSMUST00000033012.7
 Copb1
coatomer protein complex, subunit beta 1
chr2_+_119972699 0.039 ENSMUST00000066058.7
 Mapkbp1
mitogen-activated protein kinase binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.0 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.9 4.5 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.8 3.8 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.7 8.1 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.6 5.6 GO:0071493 cellular response to UV-B(GO:0071493)
0.4 1.5 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.4 2.6 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.2 2.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 8.8 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.1 1.5 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 1.4 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.1 2.4 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.1 0.2 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 2.5 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.1 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 1.1 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 0.1 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.0 0.3 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 1.3 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0070557 PCNA-p21 complex(GO:0070557)
1.0 8.8 GO:0030478 actin cap(GO:0030478)
0.8 3.8 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.2 1.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 0.9 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 2.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 2.6 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:1990745 EARP complex(GO:1990745)
0.0 4.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 8.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.9 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.6 2.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.5 4.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 3.8 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.2 2.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 0.7 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.2 1.5 GO:0071253 connexin binding(GO:0071253)
0.2 2.6 GO:0045499 chemorepellent activity(GO:0045499)
0.1 1.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.9 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 0.2 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 8.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.9 GO:0008483 transaminase activity(GO:0008483)
0.0 1.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 7.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin binding(GO:0030332)
0.0 9.3 GO:0003779 actin binding(GO:0003779)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 2.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 2.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 4.0 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 2.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.5 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 8.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 1.5 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2 2.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 5.6 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 3.8 REACTOME_UNFOLDED_PROTEIN_RESPONSE Genes involved in Unfolded Protein Response
0.0 1.3 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.9 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.7 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis