ISMARA results: Trp73

Motif ID: Trp73

Z-value: 0.461

Transcription factors associated with Trp73:

Gene Symbol	Entrez ID	Gene Name
Trp73	ENSMUSG00000029026.10	Trp73

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Trp73	mm10_v2_chr4_-_154097105_154097173	0.56	2.9e-04	Click!

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Top targets:

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Showing 1 to 20 of 71 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_+_153665274	2.692	ENSMUST00000152114.1 ENSMUST00000111812.1	Rgs8	regulator of G-protein signaling 8
chr7_-_116038734	2.676	ENSMUST00000166877.1	Sox6	SRY-box containing gene 6
chr1_+_135729147	2.083	ENSMUST00000027677.7	Csrp1	cysteine and glycine-rich protein 1
chr7_-_141443314	2.068	ENSMUST00000106005.2	Lrdd	leucine-rich and death domain containing
chr17_+_29090969	1.927	ENSMUST00000119901.1	Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)
chr12_-_45074112	1.611	ENSMUST00000120531.1 ENSMUST00000143376.1	Stxbp6	syntaxin binding protein 6 (amisyn)
chr16_-_17125106	1.438	ENSMUST00000093336.6	2610318N02Rik	RIKEN cDNA 2610318N02 gene
chrX_+_10717390	1.436	ENSMUST00000115524.1 ENSMUST00000008179.6	Mid1ip1	Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr13_+_48261427	1.389	ENSMUST00000021810.1	Id4	inhibitor of DNA binding 4
chr1_+_72824482	1.319	ENSMUST00000047328.4	Igfbp2	insulin-like growth factor binding protein 2
chr12_-_45074457	1.251	ENSMUST00000053768.6	Stxbp6	syntaxin binding protein 6 (amisyn)
chrX_+_10717451	1.220	ENSMUST00000156321.1	Mid1ip1	Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chrX_-_10216918	1.017	ENSMUST00000072393.2 ENSMUST00000044598.6 ENSMUST00000073392.4 ENSMUST00000115533.1 ENSMUST00000115532.1	Rpgr	retinitis pigmentosa GTPase regulator
chr2_-_164857542	0.973	ENSMUST00000109316.1 ENSMUST00000156255.1 ENSMUST00000128110.1 ENSMUST00000109317.3	Pltp	phospholipid transfer protein
chr4_+_62583568	0.943	ENSMUST00000098031.3	Rgs3	regulator of G-protein signaling 3
chrX_-_109013389	0.900	ENSMUST00000033597.8	Hmgn5	high-mobility group nucleosome binding domain 5
chr15_+_84232030	0.861	ENSMUST00000023072.6	Parvb	parvin, beta
chr11_-_69948145	0.828	ENSMUST00000179298.1 ENSMUST00000018710.6 ENSMUST00000135437.1 ENSMUST00000141837.2 ENSMUST00000142500.1	Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4
chr3_+_159839729	0.826	ENSMUST00000068952.5	Wls	wntless homolog (Drosophila)
chr2_-_164857671	0.797	ENSMUST00000059954.7	Pltp	phospholipid transfer protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 32 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.9	GO:0035542	regulation of SNARE complex assembly(GO:0035542)
0.2	2.7	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2	2.7	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159)
0.2	2.7	GO:0045723	positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0	2.0	GO:0070527	platelet aggregation(GO:0070527)
0.2	1.9	GO:0071493	cellular response to UV-B(GO:0071493)
0.4	1.8	GO:0042360	vitamin E metabolic process(GO:0042360)
0.3	1.4	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.1	1.4	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.3	1.3	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.1	1.3	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0	1.0	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.3	0.9	GO:0071963	establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0	0.9	GO:0006749	glutathione metabolic process(GO:0006749)
0.3	0.8	GO:0061357	Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.1	0.8	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.0	0.8	GO:0044381	glucose import in response to insulin stimulus(GO:0044381)
0.2	0.7	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.1	0.7	GO:1900194	negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.0	0.6	GO:0043252	sodium-independent organic anion transport(GO:0043252)

Gene overrepresentation in cellular_component category:

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Showing 1 to 14 of 14 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	GO:0000145	exocyst(GO:0000145)
0.1	2.3	GO:0032809	neuronal cell body membrane(GO:0032809)
0.6	1.9	GO:0070557	PCNA-p21 complex(GO:0070557)
0.2	1.4	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	1.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	1.0	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.8	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.8	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.1	0.7	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.5	GO:0061700	GATOR2 complex(GO:0061700)
0.0	0.4	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.3	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.2	GO:0005915	zonula adherens(GO:0005915)
0.0	0.0	GO:0000811	GINS complex(GO:0000811)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 26 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.9	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1	2.7	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	2.7	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.6	1.9	GO:0019912	cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2	1.4	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.2	1.3	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.9	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.2	0.8	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.1	0.8	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.1	0.8	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1	0.7	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	0.7	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.7	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.1	0.6	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1	0.5	GO:0070728	leucine binding(GO:0070728)
0.0	0.4	GO:0008483	transaminase activity(GO:0008483)
0.0	0.3	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.0	0.3	GO:0004576	oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.3	GO:0030628	pre-mRNA 3'-splice site binding(GO:0030628)
0.0	0.3	GO:0051787	misfolded protein binding(GO:0051787)

Gene overrepresentation in C2:CP category:

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Showing 1 to 9 of 9 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.9	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	1.4	PID_HDAC_CLASSII_PATHWAY	Signaling events mediated by HDAC Class II
0.0	1.0	PID_EPHRINB_REV_PATHWAY	Ephrin B reverse signaling
0.0	0.9	PID_ILK_PATHWAY	Integrin-linked kinase signaling
0.0	0.8	PID_INSULIN_GLUCOSE_PATHWAY	Insulin-mediated glucose transport
0.0	0.7	PID_PDGFRA_PATHWAY	PDGFR-alpha signaling pathway
0.0	0.7	ST_G_ALPHA_I_PATHWAY	G alpha i Pathway
0.0	0.7	PID_FOXM1_PATHWAY	FOXM1 transcription factor network
0.0	0.3	PID_PRL_SIGNALING_EVENTS_PATHWAY	Signaling events mediated by PRL

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 10 of 10 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.3	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	Genes involved in G alpha (i) signalling events
0.1	1.9	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.1	1.8	REACTOME_HDL_MEDIATED_LIPID_TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	1.4	REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	1.3	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.9	REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	0.8	REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.1	0.7	REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.4	REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.4	REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)