Motif ID: Twist1

Z-value: 1.603


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_33957671-0.173.2e-01Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_119053339 18.918 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
Gli2


GLI-Kruppel family member GLI2


chr9_+_118478851 15.033 ENSMUST00000150633.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr2_-_180225812 13.694 ENSMUST00000015791.5
Lama5
laminin, alpha 5
chr5_+_149411749 13.402 ENSMUST00000093110.5
Medag
mesenteric estrogen dependent adipogenesis
chr9_+_60794468 9.645 ENSMUST00000050183.6
Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr19_+_5740885 8.541 ENSMUST00000081496.5
Ltbp3
latent transforming growth factor beta binding protein 3
chr19_+_25610533 7.619 ENSMUST00000048935.4
Dmrt3
doublesex and mab-3 related transcription factor 3
chr7_+_45216671 7.539 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr1_+_74791516 6.640 ENSMUST00000006718.8
Wnt10a
wingless related MMTV integration site 10a
chr7_-_127218390 6.320 ENSMUST00000142356.1
ENSMUST00000106314.1
Sept1

septin 1

chr6_+_29398920 6.294 ENSMUST00000181464.1
ENSMUST00000180829.1
Ccdc136

coiled-coil domain containing 136

chr6_+_85187438 6.047 ENSMUST00000045942.8
Emx1
empty spiracles homeobox 1
chr6_-_95718800 5.737 ENSMUST00000079847.5
Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr7_-_127218303 5.472 ENSMUST00000106313.1
Sept1
septin 1
chr2_-_33942111 4.881 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
Gm13403


predicted gene 13403


chr5_-_62766153 4.763 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_+_105519388 4.510 ENSMUST00000067924.6
ENSMUST00000150981.1
Lrrc8c

leucine rich repeat containing 8 family, member C

chr6_+_83135812 4.357 ENSMUST00000065512.4
Rtkn
rhotekin
chr19_-_28963863 4.343 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr4_-_130275523 3.981 ENSMUST00000146478.1
Serinc2
serine incorporator 2
chr7_+_127800844 3.937 ENSMUST00000106271.1
ENSMUST00000138432.1
Hsd3b7

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

chr16_-_18811615 3.773 ENSMUST00000096990.3
Cdc45
cell division cycle 45
chr4_-_130275542 3.763 ENSMUST00000154846.1
ENSMUST00000105996.1
Serinc2

serine incorporator 2

chr9_+_65265173 3.742 ENSMUST00000048762.1
Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr2_-_172940299 3.588 ENSMUST00000009143.7
Bmp7
bone morphogenetic protein 7
chr7_-_70360593 3.499 ENSMUST00000032768.7
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr9_-_44342332 3.319 ENSMUST00000097558.3
Hmbs
hydroxymethylbilane synthase
chr8_+_105305572 3.185 ENSMUST00000109375.2
Elmo3
engulfment and cell motility 3
chr15_+_100304782 3.023 ENSMUST00000067752.3
Mettl7a1
methyltransferase like 7A1
chr15_+_100353149 2.983 ENSMUST00000088142.5
ENSMUST00000176287.1
ENSMUST00000075675.5
Mettl7a2

AB099516
methyltransferase like 7A2

cDNA sequence AB099516
chr7_+_27486910 2.863 ENSMUST00000008528.7
Sertad1
SERTA domain containing 1
chr8_+_72135247 2.829 ENSMUST00000003575.9
Tpm4
tropomyosin 4
chr19_-_3686549 2.776 ENSMUST00000025856.10
ENSMUST00000176867.1
Lrp5

low density lipoprotein receptor-related protein 5

chr7_-_133123770 2.693 ENSMUST00000164896.1
ENSMUST00000171968.1
Ctbp2

C-terminal binding protein 2

chr7_+_82867327 2.614 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chrX_+_71050160 2.576 ENSMUST00000082088.3
ENSMUST00000114629.3
Mamld1

mastermind-like domain containing 1

chr13_+_104109737 2.480 ENSMUST00000044385.7
Sgtb
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr11_-_68927049 2.448 ENSMUST00000038932.7
Odf4
outer dense fiber of sperm tails 4
chr11_+_60104971 2.409 ENSMUST00000064190.6
Rai1
retinoic acid induced 1
chr7_+_28180226 2.391 ENSMUST00000172467.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr13_+_104109752 2.175 ENSMUST00000160322.1
ENSMUST00000159574.1
Sgtb

small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta

chr2_-_137116624 2.142 ENSMUST00000028735.7
Jag1
jagged 1
chr15_-_57892358 2.106 ENSMUST00000022993.5
Derl1
Der1-like domain family, member 1
chr13_-_98891036 2.082 ENSMUST00000109399.2
Tnpo1
transportin 1
chr7_-_75308373 2.063 ENSMUST00000085164.5
Sv2b
synaptic vesicle glycoprotein 2 b
chr9_-_114844090 2.001 ENSMUST00000047013.3
Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr13_-_98890974 1.965 ENSMUST00000179301.1
ENSMUST00000179271.1
Tnpo1

transportin 1

chr4_-_11386757 1.944 ENSMUST00000108313.1
ENSMUST00000108311.2
Esrp1

epithelial splicing regulatory protein 1

chr7_+_28180272 1.942 ENSMUST00000173223.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr6_-_134566913 1.921 ENSMUST00000032322.8
Lrp6
low density lipoprotein receptor-related protein 6
chr18_-_67724560 1.882 ENSMUST00000120934.1
ENSMUST00000025420.7
ENSMUST00000122412.1
Ptpn2


protein tyrosine phosphatase, non-receptor type 2


chr10_-_127030813 1.879 ENSMUST00000040560.4
Tsfm
Ts translation elongation factor, mitochondrial
chr11_-_102406783 1.873 ENSMUST00000155104.1
ENSMUST00000130436.1
Slc25a39

solute carrier family 25, member 39

chr8_-_64693027 1.855 ENSMUST00000048967.7
Cpe
carboxypeptidase E
chr2_+_174110340 1.833 ENSMUST00000044415.9
Npepl1
aminopeptidase-like 1
chr11_+_102189620 1.551 ENSMUST00000070334.3
ENSMUST00000078975.7
G6pc3

glucose 6 phosphatase, catalytic, 3

chr4_-_135494615 1.531 ENSMUST00000102549.3
Nipal3
NIPA-like domain containing 3
chr10_-_127030789 1.513 ENSMUST00000120547.1
ENSMUST00000152054.1
Tsfm

Ts translation elongation factor, mitochondrial

chr13_+_73626886 1.470 ENSMUST00000022104.7
Tert
telomerase reverse transcriptase
chr8_+_13757663 1.446 ENSMUST00000043962.8
Cdc16
CDC16 cell division cycle 16
chr16_+_78930940 1.442 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
Chodl


chondrolectin


chr6_-_90716489 1.400 ENSMUST00000101153.3
Iqsec1
IQ motif and Sec7 domain 1
chr10_+_61175206 1.365 ENSMUST00000079235.5
Tbata
thymus, brain and testes associated
chr8_-_70700070 1.325 ENSMUST00000116172.1
Gm11175
predicted gene 11175
chr9_-_54661666 1.187 ENSMUST00000128624.1
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr11_-_70687917 1.169 ENSMUST00000108545.2
ENSMUST00000120261.1
ENSMUST00000036299.7
ENSMUST00000119120.1
ENSMUST00000100933.3
Camta2




calmodulin binding transcription activator 2




chr19_+_7417586 1.157 ENSMUST00000159348.1
2700081O15Rik
RIKEN cDNA 2700081O15 gene
chr1_-_172590463 1.135 ENSMUST00000065679.6
Slamf8
SLAM family member 8
chr16_-_20426375 1.059 ENSMUST00000079158.6
Abcc5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr18_+_77065195 1.043 ENSMUST00000114777.2
Pias2
protein inhibitor of activated STAT 2
chr15_+_100227819 1.022 ENSMUST00000023769.4
Atf1
activating transcription factor 1
chr2_-_26122769 1.005 ENSMUST00000140993.1
ENSMUST00000028300.5
Nacc2

nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

chr7_+_35119285 0.979 ENSMUST00000042985.9
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr6_+_83165920 0.959 ENSMUST00000077407.5
ENSMUST00000113913.1
ENSMUST00000130212.1
Dctn1


dynactin 1


chr11_+_94741782 0.945 ENSMUST00000021240.6
Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr15_+_100227871 0.905 ENSMUST00000163855.1
Atf1
activating transcription factor 1
chr8_-_70120816 0.882 ENSMUST00000002412.8
Ncan
neurocan
chr6_-_29165003 0.870 ENSMUST00000007993.9
Rbm28
RNA binding motif protein 28
chr16_+_62814676 0.862 ENSMUST00000055557.5
Stx19
syntaxin 19
chr7_+_108934405 0.858 ENSMUST00000033342.6
Eif3f
eukaryotic translation initiation factor 3, subunit F
chr4_-_135494499 0.841 ENSMUST00000105856.2
Nipal3
NIPA-like domain containing 3
chr2_+_163602294 0.773 ENSMUST00000171696.1
ENSMUST00000109408.3
Ttpal

tocopherol (alpha) transfer protein-like

chr2_-_39190687 0.728 ENSMUST00000142872.1
ENSMUST00000038874.5
Scai

suppressor of cancer cell invasion

chr9_+_111118070 0.707 ENSMUST00000035078.6
ENSMUST00000098340.2
Lrrfip2

leucine rich repeat (in FLII) interacting protein 2

chr10_-_75517324 0.691 ENSMUST00000039796.7
Gucd1
guanylyl cyclase domain containing 1
chr7_-_80401707 0.676 ENSMUST00000120753.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr7_+_4119556 0.671 ENSMUST00000079415.5
Ttyh1
tweety homolog 1 (Drosophila)
chr13_+_55209776 0.665 ENSMUST00000099490.2
Nsd1
nuclear receptor-binding SET-domain protein 1
chr12_-_51829525 0.634 ENSMUST00000179265.1
ENSMUST00000042052.8
Hectd1

HECT domain containing 1

chr10_-_127341583 0.628 ENSMUST00000026474.3
Gli1
GLI-Kruppel family member GLI1
chr11_-_100759942 0.582 ENSMUST00000107363.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr11_-_59290746 0.559 ENSMUST00000010044.7
Wnt3a
wingless-related MMTV integration site 3A
chr15_+_100334929 0.546 ENSMUST00000075420.4
Mettl7a3
methyltransferase like 7A3
chr7_+_4119525 0.536 ENSMUST00000119661.1
ENSMUST00000129423.1
Ttyh1

tweety homolog 1 (Drosophila)

chr2_-_73775341 0.508 ENSMUST00000112024.3
ENSMUST00000166199.1
ENSMUST00000180045.1
Chn1


chimerin (chimaerin) 1


chr9_-_54661870 0.494 ENSMUST00000034822.5
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr7_+_44468020 0.410 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
Josd2


Josephin domain containing 2


chr8_-_122476036 0.385 ENSMUST00000014614.3
Rnf166
ring finger protein 166
chr11_-_119355484 0.321 ENSMUST00000100172.2
ENSMUST00000005173.4
Sgsh

N-sulfoglucosamine sulfohydrolase (sulfamidase)

chr3_+_90051630 0.299 ENSMUST00000159064.1
4933434E20Rik
RIKEN cDNA 4933434E20 gene
chr17_+_24850654 0.287 ENSMUST00000130989.1
ENSMUST00000024974.9
Hagh

hydroxyacyl glutathione hydrolase

chr9_+_55150050 0.251 ENSMUST00000122441.1
Ube2q2
ubiquitin-conjugating enzyme E2Q (putative) 2
chr11_+_72207537 0.245 ENSMUST00000021158.3
Txndc17
thioredoxin domain containing 17
chr11_+_87737530 0.228 ENSMUST00000093955.5
Supt4a
suppressor of Ty 4A
chr7_+_44468051 0.219 ENSMUST00000118493.1
Josd2
Josephin domain containing 2
chr9_-_108567336 0.202 ENSMUST00000074208.4
Ndufaf3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr17_+_16972910 0.163 ENSMUST00000071374.5
BC002059
cDNA sequence BC002059
chr17_+_24850484 0.133 ENSMUST00000118788.1
Hagh
hydroxyacyl glutathione hydrolase
chrX_-_18461371 0.128 ENSMUST00000044188.4
4930578C19Rik
RIKEN cDNA 4930578C19 gene
chr2_-_142901506 0.118 ENSMUST00000043589.7
Kif16b
kinesin family member 16B
chr17_+_34039437 0.101 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
Col11a2



collagen, type XI, alpha 2



chr9_+_109082485 0.099 ENSMUST00000026735.7
Ccdc51
coiled-coil domain containing 51
chr6_-_124813065 0.078 ENSMUST00000149610.2
Tpi1
triosephosphate isomerase 1
chr2_-_32784424 0.074 ENSMUST00000102813.1
1700019L03Rik
RIKEN cDNA 1700019L03 gene
chr17_-_12992487 0.051 ENSMUST00000159551.1
ENSMUST00000160781.1
Wtap

Wilms' tumour 1-associating protein

chr11_-_72207413 0.047 ENSMUST00000108505.1
4933427D14Rik
RIKEN cDNA 4933427D14 gene
chr8_-_126475062 0.043 ENSMUST00000170518.1
Gm17296
predicted gene, 17296
chr7_-_29232478 0.028 ENSMUST00000085818.4
Kcnk6
potassium inwardly-rectifying channel, subfamily K, member 6
chr13_+_67863324 0.027 ENSMUST00000078471.5
BC048507
cDNA sequence BC048507

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
4.9 19.5 GO:0060032 notochord regression(GO:0060032)
3.6 3.6 GO:0090194 negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194)
2.9 11.8 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
2.8 8.5 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.6 14.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
1.5 1.5 GO:1904173 regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
1.3 3.8 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.1 7.7 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.9 2.8 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.8 3.4 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.7 3.5 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.6 1.9 GO:0061324 trachea cartilage morphogenesis(GO:0060535) mammary placode formation(GO:0060596) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901963)
0.6 5.7 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.6 1.9 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145) regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.6 3.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.6 1.9 GO:0030070 insulin processing(GO:0030070)
0.6 3.9 GO:0035754 B cell chemotaxis(GO:0035754)
0.6 0.6 GO:0042660 positive regulation of cell fate specification(GO:0042660)
0.5 9.6 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.5 1.6 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.5 6.3 GO:0001675 acrosome assembly(GO:0001675)
0.5 6.0 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.4 15.6 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.4 2.1 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.4 2.0 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.4 7.5 GO:0048368 lateral mesoderm development(GO:0048368)
0.4 1.1 GO:2000508 regulation of dendritic cell chemotaxis(GO:2000508)
0.4 2.6 GO:0072697 protein localization to cell cortex(GO:0072697)
0.4 4.0 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.3 2.7 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.3 3.3 GO:0018065 protein-cofactor linkage(GO:0018065)
0.2 12.8 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.2 0.6 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.2 1.0 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.2 0.7 GO:0090472 dibasic protein processing(GO:0090472)
0.1 2.1 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 2.4 GO:0015693 magnesium ion transport(GO:0015693)
0.1 4.3 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.7 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.1 0.3 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.1 0.7 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.1 1.0 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.1 1.0 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 0.9 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 0.9 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.1 1.9 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 1.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 1.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 1.2 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 1.7 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.9 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 1.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.4 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.7 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.1 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.0 0.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 4.5 GO:0045444 fat cell differentiation(GO:0045444)
0.0 0.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 3.2 GO:0006909 phagocytosis(GO:0006909)
0.0 1.9 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.0 1.2 GO:0046847 filopodium assembly(GO:0046847)
0.0 2.9 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 1.9 GO:0007266 Rho protein signal transduction(GO:0007266)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 13.7 GO:0043259 laminin-10 complex(GO:0043259)
2.5 7.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)
2.4 9.6 GO:0043293 apoptosome(GO:0043293)
1.5 19.5 GO:0097542 ciliary tip(GO:0097542)
1.3 11.8 GO:0072687 meiotic spindle(GO:0072687)
1.3 3.8 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
1.0 5.7 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.8 2.5 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.5 1.9 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.4 1.2 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.3 2.4 GO:0001520 outer dense fiber(GO:0001520)
0.3 1.0 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.3 6.3 GO:0002080 acrosomal membrane(GO:0002080)
0.3 2.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.2 2.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 2.7 GO:0097470 ribbon synapse(GO:0097470)
0.1 1.9 GO:0031045 dense core granule(GO:0031045)
0.1 0.9 GO:0031201 SNARE complex(GO:0031201)
0.1 0.9 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 1.0 GO:0005869 dynactin complex(GO:0005869)
0.1 1.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 1.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 15.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.7 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 1.0 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 3.3 GO:0000793 condensed chromosome(GO:0000793)
0.0 3.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.4 GO:0005811 lipid particle(GO:0005811)
0.0 5.4 GO:0070062 extracellular exosome(GO:0070062)
0.0 2.1 GO:0043195 terminal bouton(GO:0043195)
0.0 2.3 GO:0034399 nuclear periphery(GO:0034399)
0.0 3.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.0 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0004774 succinate-CoA ligase activity(GO:0004774)
1.6 4.7 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.7 3.9 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.6 1.9 GO:0097677 STAT family protein binding(GO:0097677)
0.6 7.7 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.6 3.3 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.5 4.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.5 16.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 5.7 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.4 7.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.4 3.6 GO:0070700 BMP receptor binding(GO:0070700)
0.3 8.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.3 2.7 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.3 3.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.3 3.5 GO:0001972 retinoic acid binding(GO:0001972)
0.3 2.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 15.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 0.6 GO:0005110 frizzled-2 binding(GO:0005110)
0.2 1.9 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 6.6 GO:0005109 frizzled binding(GO:0005109)
0.2 0.7 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.2 1.6 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.2 1.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 2.1 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 1.0 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 1.5 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 3.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 4.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 2.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 13.7 GO:0005178 integrin binding(GO:0005178)
0.1 2.6 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 4.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 2.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 4.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 1.0 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.1 2.1 GO:0005112 Notch binding(GO:0005112)
0.1 0.7 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 1.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.4 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 1.8 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 11.8 GO:0005525 GTP binding(GO:0005525)
0.0 1.0 GO:0070840 dynein complex binding(GO:0070840)
0.0 1.0 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 2.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 9.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.8 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 13.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.6 18.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 3.6 PID_ALK2_PATHWAY ALK2 signaling events
0.2 11.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 15.0 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.2 5.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 6.2 PID_ARF6_PATHWAY Arf6 signaling events
0.1 8.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 10.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 1.0 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 0.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.9 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.9 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 2.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.9 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.3 5.7 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 7.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 3.8 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 4.0 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.2 2.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 2.6 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 1.9 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.2 3.3 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 11.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 7.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.4 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 0.7 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.1 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.9 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 1.5 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 3.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 5.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.0 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels