Motif ID: Twist1

Z-value: 1.603


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_33957671-0.173.2e-01Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

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Top targets:


Showing 1 to 20 of 119 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_119053339 18.918 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr9_+_118478851 15.033 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr2_-_180225812 13.694 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr5_+_149411749 13.402 ENSMUST00000093110.5
 Medag
mesenteric estrogen dependent adipogenesis
chr9_+_60794468 9.645 ENSMUST00000050183.6
 Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr19_+_5740885 8.541 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr19_+_25610533 7.619 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr7_+_45216671 7.539 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr1_+_74791516 6.640 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr7_-_127218390 6.320 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr6_+_29398920 6.294 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr6_+_85187438 6.047 ENSMUST00000045942.8
 Emx1
empty spiracles homeobox 1
chr6_-_95718800 5.737 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr7_-_127218303 5.472 ENSMUST00000106313.1
 Sept1
septin 1
chr2_-_33942111 4.881 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
 Gm13403


predicted gene 13403


chr5_-_62766153 4.763 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_+_105519388 4.510 ENSMUST00000067924.6
ENSMUST00000150981.1
 Lrrc8c

leucine rich repeat containing 8 family, member C

chr6_+_83135812 4.357 ENSMUST00000065512.4
 Rtkn
rhotekin
chr19_-_28963863 4.343 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr4_-_130275523 3.981 ENSMUST00000146478.1
 Serinc2
serine incorporator 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.9 19.5 GO:0060032 notochord regression(GO:0060032)
0.4 15.6 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
5.0 15.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.6 14.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.2 12.8 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
2.9 11.8 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
0.5 9.6 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
2.8 8.5 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.1 7.7 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.4 7.5 GO:0048368 lateral mesoderm development(GO:0048368)
0.5 6.3 GO:0001675 acrosome assembly(GO:0001675)
0.5 6.0 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.6 5.7 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 4.5 GO:0045444 fat cell differentiation(GO:0045444)
0.1 4.3 GO:0007520 myoblast fusion(GO:0007520)
0.4 4.0 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.6 3.9 GO:0035754 B cell chemotaxis(GO:0035754)
1.3 3.8 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.6 3.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
3.6 3.6 GO:0090194 negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 19.5 GO:0097542 ciliary tip(GO:0097542)
0.0 15.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
3.4 13.7 GO:0043259 laminin-10 complex(GO:0043259)
1.3 11.8 GO:0072687 meiotic spindle(GO:0072687)
2.4 9.6 GO:0043293 apoptosome(GO:0043293)
2.5 7.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.3 6.3 GO:0002080 acrosomal membrane(GO:0002080)
1.0 5.7 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 5.4 GO:0070062 extracellular exosome(GO:0070062)
1.3 3.8 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 3.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 3.3 GO:0000793 condensed chromosome(GO:0000793)
0.2 2.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 2.7 GO:0097470 ribbon synapse(GO:0097470)
0.8 2.5 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.3 2.4 GO:0001520 outer dense fiber(GO:0001520)
0.0 2.3 GO:0034399 nuclear periphery(GO:0034399)
0.3 2.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 2.1 GO:0043195 terminal bouton(GO:0043195)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 16.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 15.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 13.7 GO:0005178 integrin binding(GO:0005178)
0.0 11.8 GO:0005525 GTP binding(GO:0005525)
0.0 9.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.3 8.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.6 7.7 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.4 7.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 6.6 GO:0005109 frizzled binding(GO:0005109)
1.9 5.7 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.4 5.7 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 4.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.6 4.7 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.5 4.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 4.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 4.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.7 3.9 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.3 3.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 3.6 GO:0070700 BMP receptor binding(GO:0070700)
0.3 3.5 GO:0001972 retinoic acid binding(GO:0001972)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 18.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 15.0 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
1.7 13.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 11.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 10.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 8.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 6.2 PID_ARF6_PATHWAY Arf6 signaling events
0.2 5.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 3.6 PID_ALK2_PATHWAY ALK2 signaling events
0.1 3.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.9 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.9 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 1.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 1.0 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 0.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 7.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 7.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 5.7 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 5.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 4.0 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.5 3.9 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 3.8 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 3.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 3.3 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 2.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 2.6 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 2.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 1.9 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 1.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.9 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 1.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.5 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 1.4 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 1.1 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism